INT6833

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.05
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
bands 1
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 6 98.20 Very High Very High Very High
antagonist 4 88.08 High High
Opioid 2 87.64 High High
Antinociceptive 2 76.24 Quite High
opioid receptor 4 75.00 Quite High
cytokine 15 68.20 Quite High
Morphine 4 66.72 Quite High
analgesia 4 65.36 Quite High
Immobilon 1 57.12 Quite High
tail-flick 2 49.68 Quite Low
Disease Link Frequency Relevance Heat
Pharynx Cancer 3 54.04 Quite High
Stress 96 50.00 Quite Low
Skin Cancer 10 50.00 Quite Low
Epstein-barr Virus 15 48.28 Quite Low
Papillomavirus Infection 19 37.60 Quite Low
Apoptosis 3 30.00 Quite Low
Cancer 70 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 14 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To detect the association of Notch1 and periostin proteins, we performed immunoprecipitation of Notch1 by using anti-FLAG antibody followed by Western blot analysis using anti-periostin antibody, revealing the presence of periostin in the precipitate of Notch1 (Fig. 1B).
Notch1 Binding (association) of
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Whole-cell lysates from the transfectants revealed 2 bands of Notch1, the precursor and the N1™ of the S1-cleaved heterodimeric Notch1 and the periostin (Fig. 1B).
Notch1 Binding (bands) of in bands
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Taken together, the above data led us to propose that periostin affected Notch1 maturation by physical association with its precursor inside of the cells to increase the localization of mature Notch1 protein at the cell surface.
Notch1 protein Binding (association) of
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Reversible binding of BAN and TAN had Ki values of 1 x 10(-9) and 1 x 10(-10) M, respectively as determined by log probit plots.
TAN Binding (binding) of
4) Confidence 0.30 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1334238 Disease Relevance 0 Pain Relevance 0.32
Western blot for activated Notch1
Notch1 Binding (blot) of
5) Confidence 0.30 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.05 Pain Relevance 0.06
At a concentration of 5 x 10(-8) and 1 x 10(-8) M for BAN and TAN irreversible binding was inhibited 50% of the maximum value.
TAN Binding (binding) of
6) Confidence 0.22 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1334238 Disease Relevance 0 Pain Relevance 0.56

General Comments

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