INT68332

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.11
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM1) nucleus (GRM1) signal transducer activity (GRM1)
Anatomy Link Frequency
spinal 1
neurons 1
brain 1
SON 1
GRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 13 100.00 Very High Very High Very High
Glutamate 27 99.90 Very High Very High Very High
nMDA receptor 2 99.80 Very High Very High Very High
c fibre 6 99.08 Very High Very High Very High
Endocannabinoid 15 98.32 Very High Very High Very High
Rostral ventromedial medulla 16 97.84 Very High Very High Very High
spinal dorsal horn 2 97.74 Very High Very High Very High
analgesia 13 96.80 Very High Very High Very High
long-term potentiation 8 96.52 Very High Very High Very High
ischemia 4 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Amnesia 2 98.92 Very High Very High Very High
Neurodegenerative Disease 1 97.48 Very High Very High Very High
Status Epilepticus 1 97.16 Very High Very High Very High
Cv General 4 Under Development 2 96.36 Very High Very High Very High
Convulsion 1 96.32 Very High Very High Very High
Death 3 95.96 Very High Very High Very High
Brain Injury 2 95.52 Very High Very High Very High
Urological Neuroanatomy 32 88.52 High High
Pain 43 83.52 Quite High
Motor Neuron Diseases 1 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of group I receptors (mGluR1 and/or mGluR5) on presynaptic somata/dendrites led to an increase in spike-dependent transmitter release, whereas activation of the group III receptors (mGluR4, 7, and/or 8) on presynaptic terminals suppressed glutamate and GABA release onto SON neurons.
Positive_regulation (Activation) of mGluR1 in SON associated with gaba and glutamate
1) Confidence 0.67 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9065826 Disease Relevance 0 Pain Relevance 0.43
These findings suggest that the induction of LTP of C fibre-evoked field potentials in the spinal dorsal horn by high-frequency, high-intensity stimulation of afferent C fibres requires a group-specific mGluR recruitment, activation of mGluR1/5 but not that of mGluR4/6-8 and mGluR2/3 being a requisite step.
Positive_regulation (activation) of mGluR1 in spinal associated with c fibre, spinal dorsal horn and long-term potentiation
2) Confidence 0.67 Published 2003 Journal Pain Section Abstract Doc Link 14659520 Disease Relevance 0 Pain Relevance 0.86
Endogenous glutamate, by activating NMDA, AMPA or mGluR1 receptors, may contribute to the brain damage occurring acutely after status epilepticus, cerebral ischemia or traumatic brain injury.
Positive_regulation (activating) of mGluR1 in brain associated with glutamate, cv general 4 under development, ischemia, status epilepticus and brain injury
3) Confidence 0.49 Published 2000 Journal J. Nutr. Section Abstract Doc Link 10736372 Disease Relevance 0.80 Pain Relevance 0.50
In addition, several modulator systems are activated as locomotion is initiated, including the tachykinin system and the metabotropic glutamate receptor 1 (mGluR1), the latter operating partially via the endocannabinoid system.
Positive_regulation (activated) of mGluR1 associated with endocannabinoid and glutamate receptor
4) Confidence 0.49 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19571197 Disease Relevance 0 Pain Relevance 0.36
This
               raises the intriguing possibility that pharmacological activation of particular mGlu
               receptor subtypes may slow the progression of neurodegenerative disorders through a
               non conventional mechanism based on the production of endogenous neurotrophic
               factor. 
Positive_regulation (activation) of mGlu associated with neurodegenerative disease
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.37 Pain Relevance 0.19
TRPV1 receptor stimulation is associated with increased glutamate release and activation of group I mGlu and NMDA receptors and with modulation of downstream RVM ON and OFF neurons.
Positive_regulation (activation) of mGlu in neurons associated with glutamate, nmda receptor and rostral ventromedial medulla
6) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.88 Pain Relevance 1.25
BV2 cells express only one Class C GPCR at a significant, albeit, low mRNA level: the metabotropic glutamate receptor, mGluR1 (Grm1).
Positive_regulation (metabotropic) of Grm1 associated with glutamate receptor
7) Confidence 0.18 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.06 Pain Relevance 0.24

General Comments

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