INT68339

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.71
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HDAC2) nucleus (HDAC2) enzyme binding (HDAC2)
transcription factor binding (HDAC2) cytoplasm (HDAC2)
Anatomy Link Frequency
synovium 1
Mns 1
HDAC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 99.52 Very High Very High Very High
Osteoarthritis 36 98.72 Very High Very High Very High
Inflammation 30 92.48 High High
anesthesia 1 84.12 Quite High
aspirin 5 83.32 Quite High
cINOD 8 81.88 Quite High
cytokine 5 59.76 Quite High
Inflammatory mediators 2 54.40 Quite High
Arthritis 5 48.24 Quite Low
corticosteroid 2 7.68 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 74 99.52 Very High Very High Very High
Frailty 38 98.72 Very High Very High Very High
INFLAMMATION 35 92.48 High High
Colon Cancer 40 63.76 Quite High
Disease 10 62.88 Quite High
Cancer 17 50.00 Quite Low
Necrosis 4 50.00 Quite Low
Arthritis 5 48.24 Quite Low
Dysphagia 3 46.72 Quite Low
Injury 1 32.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HD2-Mns produced depolarizations with longer latencies and durations than those of the HD1-Mns.
Gene_expression (produced) of HD2 in Mns
1) Confidence 0.51 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9065858 Disease Relevance 0 Pain Relevance 0.08
Second, they demonstrated lower levels of HDAC1, and HDAC2 protein in RA synovium than in OA by Western blotting of whole cell lysates, with ?
Gene_expression (levels) of HDAC2 in synovium associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.59 Pain Relevance 0.72
In these cells curcumin or demethoxycurcumin upregulated expression of cyclin-dependent kinase inhibitor 2D (p19INK4D) and downregulated expression of PCNA, HDAC2, MAP2K1 and PLAU.
Gene_expression (expression) of HDAC2
3) Confidence 0.26 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.12 Pain Relevance 0.30

General Comments

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