INT68359

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 4.63
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (HPGDS) signal transduction (HPGDS) nucleolus (HPGDS)
nucleus (HPGDS) cytoplasm (HPGDS)
Anatomy Link Frequency
endothelial cell 1
internal 1
upper 1
HPGDS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 95.82 Very High Very High Very High
Inflammation 32 95.44 Very High Very High Very High
cINOD 17 94.24 High High
tolerance 9 77.12 Quite High
Analgesic 1 76.28 Quite High
Potency 4 56.64 Quite High
Osteoarthritis 47 54.88 Quite High
cva 2 51.20 Quite High
aspirin 3 25.00 Low Low
sSRI 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 122 99.98 Very High Very High Very High
Apoptosis 41 98.84 Very High Very High Very High
INFLAMMATION 38 95.44 Very High Very High Very High
Cancer 71 94.68 High High
Aging 15 91.68 High High
Gastrointestinal Neoplasms 1 91.32 High High
Breast Cancer 194 89.84 High High
Disease 42 85.32 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 74.56 Quite High
Osteoarthritis 48 54.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the Alpha-class hGSTA5 gene product has been omitted from tabulations of human GSTs, because its expression has never been detected in human cells.
Positive_regulation (tabulations) of GSTs
1) Confidence 0.32 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0
These include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease Matrix Metalloproteinase (MMP) activity, block the cell cycle in the S or G2/M phases to interfere with processes of cell division, suppress O2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione S-transferases (GSTs) and/or NAD(P)H quinine oxidoreductase (NQO1), suppress the phosphorylation of Akt/PKB as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (NOS) and cyclooxygenase (COX), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (HUVEC).
Positive_regulation (induce) of GSTs in endothelial cell associated with inflammation and metalloproteinase
2) Confidence 0.31 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754420 Disease Relevance 0.45 Pain Relevance 0.23
-induced increase in L-PGDS expression corresponded with an increase in PGDS activity, we measured PGD2 levels in conditioned media.
Positive_regulation (increase) of PGDS
3) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.11 Pain Relevance 0.05
Elevation of the levels of GSTs, a family of biotransformation enzymes with many functions such as detoxification of carcinogens, might be one of the mechanisms that lead to cancer prevention.
Spec (might) Positive_regulation (Elevation) of GSTs associated with cancer
4) Confidence 0.15 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0.27 Pain Relevance 0.18
Enhancement of GSTs, a family of detoxification enzymes consisting of class alpha, mu, pi and theta isoforms, might be one of the mechanisms leading to cancer prevention.
Spec (might) Positive_regulation (Enhancement) of GSTs associated with cancer
5) Confidence 0.15 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9729437 Disease Relevance 0.34 Pain Relevance 0.42
ITCs are also able to induce glutathione S-transferases (GSTs) and/or other antioxidant enzymes through the stress-signaling pathway involving oxidative stress [22].
Positive_regulation (induce) of GSTs associated with stress
6) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 1.00 Pain Relevance 0.03
GSTs are induced under conditions of oxidative stress, and alpha-, pi-, mu-, and theta-class GSTs are active in detoxification of numerous products, including reactive oxidant damage to DNA and lipids, such as organic epoxides, lipid hydroperoxides, and unsaturated aldehydes [58,59].
Positive_regulation (induced) of GSTs associated with stress
7) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 0.72 Pain Relevance 0
Enhancement of GSTs in the upper part of the digestive tract, resulting in a more efficient detoxification, may explain in part the anticarcinogenic properties of NSAIDs.
Positive_regulation (Enhancement) of GSTs in upper associated with cinod
8) Confidence 0.12 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9067546 Disease Relevance 0.13 Pain Relevance 0.22
Electrophilic xenobiotics and endogenous products from oxidative stresses induce the glutathione S-transferases (GSTs), which form a large family within the phase II enzymes over both animal and plant kingdoms.
Positive_regulation (induce) of GSTs associated with stress
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2822842 Disease Relevance 0.50 Pain Relevance 0
We have tested this hypothesis by choosing allyl isothiocyanate (AITC), a functional ingredient in wasabi, as a candidate food ingredient that induces GSTs without causing adverse effects on animals' lives.
Positive_regulation (induces) of GSTs
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2822842 Disease Relevance 0.57 Pain Relevance 0.04
The GSTs thus induced in turn detoxify these external as well as internal stresses.
Positive_regulation (induced) of GSTs in internal associated with stress
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2822842 Disease Relevance 0.53 Pain Relevance 0

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