INT68372

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 8
Speculated 4
Reported most in Abstract
Documents 28
Total Number 32
Disease Relevance 5.64
Pain Relevance 9.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
plasma 7
liver 2
Blood 1
colon 1
2B7 1
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 100.00 Very High Very High Very High
cINOD 43 99.90 Very High Very High Very High
fluoxetine 50 99.84 Very High Very High Very High
methadone 9 99.52 Very High Very High Very High
Opioid 3 99.24 Very High Very High Very High
tricyclic antidepressant 1 98.28 Very High Very High Very High
tramadol 1 97.08 Very High Very High Very High
Codeine 1 96.68 Very High Very High Very High
analgesia 2 96.08 Very High Very High Very High
antidepressant 9 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 36 99.96 Very High Very High Very High
INFLAMMATION 43 98.96 Very High Very High Very High
Breast Cancer 3 98.96 Very High Very High Very High
Adenoma 4 98.28 Very High Very High Very High
Cardiovascular Disease 6 97.90 Very High Very High Very High
Colon Cancer 2 93.52 High High
Chronic Renal Insufficiency 1 91.24 High High
Thrombosis 4 91.04 High High
Cancer 118 90.52 High High
Diarrhoea 4 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two common variants of the CYP2C9 gene (CYP2C9*2 and *3) were reported to significantly affect the activity of the CYP2C9 enzyme.
Regulation (affect) of CYP2C9
1) Confidence 0.62 Published 2007 Journal Gastroenterology Section Abstract Doc Link 17681167 Disease Relevance 0.32 Pain Relevance 0.35
Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes.
Regulation (Effects) of CYP2C9 in liver associated with fluoxetine
2) Confidence 0.60 Published 2001 Journal Acta Pharmacol. Sin. Section Title Doc Link 11730569 Disease Relevance 0 Pain Relevance 0.19
The levels of other CYP proteins, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, were not affected by eletriptan.
Neg (not) Regulation (affected) of CYP2C9
3) Confidence 0.55 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10611140 Disease Relevance 0.06 Pain Relevance 0.15
However, data generated in a broad warfarin consortium have demonstrated an additive informative value of genetic data on VKORC1 and CYP2C9 even when it is obtained 7–9 days after the start of treatment [35].
Regulation (value) of CYP2C9
4) Confidence 0.52 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958670 Disease Relevance 0 Pain Relevance 0
Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites.
Regulation (Influence) of CYP2C9
5) Confidence 0.45 Published 2003 Journal Pharmacogenetics Section Title Doc Link 12893985 Disease Relevance 0.09 Pain Relevance 0.09
In-vitro data indicate major effects of the genetically polymorphic cytochrome P450 enzyme 2C9 (CYP2C9) on the pharmacokinetics of celecoxib, a nonsteroidal anti-inflammatory drug acting as selective cyclooxygenase-2 inhibitor.
Regulation (effects) of CYP2C9 associated with inflammation and cinod
6) Confidence 0.45 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12893985 Disease Relevance 0.10 Pain Relevance 0.10
Decreased concentrations of carboxy- and hydroxy-celecoxib in heterozygous and homozygous carriers of CYP2C9*3 were detected which supported the influence of CYP2C9 polymorphisms on celecoxib pharmacokinetic variability.
Regulation (influence) of CYP2C9
7) Confidence 0.45 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12893985 Disease Relevance 0.05 Pain Relevance 0.05
Effect of CYP2D6 and CYP2C9 genotypes on fluoxetine and norfluoxetine plasma concentrations during steady-state conditions.
Regulation (Effect) of CYP2C9 in plasma associated with fluoxetine
8) Confidence 0.45 Published 2004 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 14726986 Disease Relevance 0 Pain Relevance 0.36
The aim of the present study was to evaluate the influence of CYP2D6 and CYP2C9 genotypes on the plasma concentration of fluoxetine and norfluoxetine in psychiatric patients during steady-state conditions.
Regulation (influence) of CYP2C9 in plasma associated with fluoxetine
9) Confidence 0.45 Published 2004 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 14726986 Disease Relevance 0 Pain Relevance 0.36
The influence of ticlopidine on CYP2C9, the other cytochrome P450 isoform that metabolizes phenytoin, is relatively weak, with a calculated Ki of 38.8 +/- 27 mumol/L.
Regulation (influence) of CYP2C9
10) Confidence 0.44 Published 1997 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9390115 Disease Relevance 0.25 Pain Relevance 0.08
We also determined the role of cytochrome P450 2C9 (CYP2C9) polymorphism on coumarin dosage and INR in NSAID users.
Spec (determined) Regulation (role) of CYP2C9 associated with cinod
11) Confidence 0.41 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 14691574 Disease Relevance 0.17 Pain Relevance 0.47
Two aspects have been particularly taken into account: the changes or absence of changes in plasma/serum concentrations of concomitant drugs and the direct or indirect evidence of induction, inhibition or lack of effect on the six major human hepatic CYP isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4), as well as on other CYP isozymes or enzyme systems.
Regulation (effect) of CYP2C9 in plasma
12) Confidence 0.39 Published 2000 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11030437 Disease Relevance 0 Pain Relevance 0.20
We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone pharmacokinetics and on the response to treatment.
Spec (determine) Regulation (influence) of CYP2C9 associated with methadone
13) Confidence 0.37 Published 2005 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 16338275 Disease Relevance 0 Pain Relevance 0.27
Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine.
Regulation (Influence) of CYP2C9 in plasma associated with fluoxetine
14) Confidence 0.37 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 16236141 Disease Relevance 0 Pain Relevance 0.76
We also determined the role of cytochrome P450 2C9 (CYP2C9) polymorphism on coumarin dosage and INR in NSAID users.
Spec (determined) Regulation (role) of cytochrome P450 2C9 associated with cinod
15) Confidence 0.35 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 14691574 Disease Relevance 0.17 Pain Relevance 0.47
However, the up-regulation of GR fits well to the increased expression of CYP2C9 because GR plays an important role in transcriptional regulation of the CYP2C9 gene (Gerbal-Chaloin et al. 2002).
Regulation (regulation) of CYP2C9
16) Confidence 0.35 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.57 Pain Relevance 0
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Spec (investigated) Regulation (Effects) of CYP2C9 in 2B7 associated with morphine
17) Confidence 0.35 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.23
In the present study, the influence of CYP2D6, CYP2C9 and CYP2C19 polymorphisms on the steady-state plasma concentrations of fluoxetine and norfluoxetine enantiomers was evaluated in 78 patients receiving chronic fluoxetine treatment (10-60 mg/day).
Regulation (influence) of CYP2C9 in plasma associated with fluoxetine
18) Confidence 0.31 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16236141 Disease Relevance 0 Pain Relevance 0.91
Fluoxetine metabolism involves CYP2D6 and CYP2C9 in the formation of its major metabolite, norfluoxetine.
Regulation (involves) of CYP2C9 associated with fluoxetine
19) Confidence 0.29 Published 2001 Journal J Clin Pharmacol Section Abstract Doc Link 11304903 Disease Relevance 0.18 Pain Relevance 0.69
Blood levels of some NSAIDs are dependent on CYP2C9 activity, whereas opioid-receptor polymorphisms are discussed for differences in opioid mediated analgesia and side effects.
Regulation (dependent) of CYP2C9 in Blood associated with cinod, opioid and analgesia
20) Confidence 0.29 Published 2007 Journal Expert Opin Pharmacother Section Abstract Doc Link 17927480 Disease Relevance 0.08 Pain Relevance 0.97

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox