INT68373

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 59
Total Number 61
Disease Relevance 60.46
Pain Relevance 9.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FLNA) extracellular region (FLNA) plasma membrane (FLNA)
nucleus (FLNA) transcription factor binding (FLNA) cytoplasm (FLNA)
Anatomy Link Frequency
brachial artery 3
muscle 2
blood 2
Endothelium 2
plasma 1
FLNA (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 12 99.78 Very High Very High Very High
Migraine 28 99.52 Very High Very High Very High
depression 36 99.50 Very High Very High Very High
rheumatoid arthritis 297 99.32 Very High Very High Very High
Inflammation 285 99.28 Very High Very High Very High
Angina 69 99.28 Very High Very High Very High
Pain 30 99.16 Very High Very High Very High
cva 44 98.88 Very High Very High Very High
aspirin 53 98.66 Very High Very High Very High
ischemia 87 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1296 100.00 Very High Very High Very High
Cardiovascular Disease 821 100.00 Very High Very High Very High
Hyperemia 115 100.00 Very High Very High Very High
Systemic Sclerosis 1070 99.84 Very High Very High Very High
Coronary Artery Disease 315 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 110 99.84 Very High Very High Very High
Hyperhomocysteinemia 12 99.82 Very High Very High Very High
Hyperglycemia 48 99.76 Very High Very High Very High
Syndrome 60 99.52 Very High Very High Very High
Headache 29 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis detected a slight decrease in filamin-A and vimentin in WT samples, while the decrease in annexin A1 or A2 was less obvious (Fig. 5A).
Negative_regulation (decrease) of filamin-A
1) Confidence 0.57 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.06 Pain Relevance 0
The difference of 2 FMD% we chose for the power calculations is also used for power calculations in other studies [52–54], and in our lab de Roos et al. [55] showed that replacement of dietary saturated fatty acids by trans fatty acids impaired FMD by 1.8 FMD%.
Negative_regulation (impaired) of FMD
2) Confidence 0.51 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0 Pain Relevance 0
In one study, replacement of dietary saturated fatty acids by dietary trans fatty acids impaired FMD after 4 wk of intervention [34], but no effect was found of a low-fat diet versus a high-oil diet on FMD [35].
Negative_regulation (impaired) of FMD in fat
3) Confidence 0.51 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488898 Disease Relevance 0.41 Pain Relevance 0.11
In patients with IMT > 0.8 mm (6 patients in each group) a significant decrease of FMD was found as compared with patients with normal IMT (p < 0.05).
Negative_regulation (decrease) of FMD in IMT
4) Confidence 0.50 Published 2003 Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Section Abstract Doc Link 15037906 Disease Relevance 0.71 Pain Relevance 0.46
During painful stimulation both Highs and Lows showed a decrease of FMD, but it was significantly less pronounced in Highs.
Negative_regulation (decrease) of FMD associated with pain and increased venous pressure under development
5) Confidence 0.50 Published 2005 Journal Pain Section Abstract Doc Link 15979790 Disease Relevance 0.87 Pain Relevance 0.93
An explanation for the fact that we did not find an impairment in FMD following methionine loading could be that we used a lower dose of methionine (50 mg of methionine per kilogram of body weight) than most other studies do (100 mg of methionine per kilogram of body weight).
Negative_regulation (impairment) of FMD in body associated with body weight
6) Confidence 0.38 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.24 Pain Relevance 0
We found that methionine-induced hyperhomocysteinemia did not impair FMD in healthy elderly volunteers.
Negative_regulation (impair) of FMD associated with hyperhomocysteinemia
7) Confidence 0.38 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.35 Pain Relevance 0.09
In one study FMD was not acutely impaired after test meals with saturated or trans fatty acids [57].


Negative_regulation (impaired) of FMD
8) Confidence 0.38 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1488894 Disease Relevance 0.19 Pain Relevance 0
During the administration of painful stimulation together with the instruction of analgesia, only Highs reported analgesia and their FMD no longer decreased.
Negative_regulation (decreased) of FMD associated with pain, increased venous pressure under development and analgesia
9) Confidence 0.37 Published 2005 Journal Pain Section Abstract Doc Link 15979790 Disease Relevance 0.84 Pain Relevance 0.95
Thus, we must pay much attention in the patients with impaired FMD even in the normal coronary angiograms.
Negative_regulation (impaired) of FMD associated with increased venous pressure under development
10) Confidence 0.37 Published 2007 Journal Atherosclerosis Section Abstract Doc Link 17125773 Disease Relevance 0.80 Pain Relevance 0.07
Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD).
Negative_regulation (reduction) of FMD in brachial artery associated with stress and increased venous pressure under development
11) Confidence 0.37 Published 2005 Journal Pain Section Abstract Doc Link 15979790 Disease Relevance 0.57 Pain Relevance 0.31
A significant decrease in FMD was observed in patients after exercise (at 30 minutes: 3.92 +/- 1.78% vs 7.03 +/- 1.99% at baseline, p < 0.001; at 2 hours: 6.36 +/- 2.12% vs 7.03 +/- 1.99% at baseline, p = 0.005), followed by a gradual return to its baseline value, whereas FMD in controls non-significantly increased after exercise.
Negative_regulation (decrease) of FMD
12) Confidence 0.37 Published 2008 Journal Vasc Med Section Abstract Doc Link 18940901 Disease Relevance 0.72 Pain Relevance 0.15
Baseline FMD values were significantly diminished in patients (7.03 +/- 1.99% vs 8.22 +/- 1.60% in controls, p = 0.009).
Negative_regulation (diminished) of FMD
13) Confidence 0.37 Published 2008 Journal Vasc Med Section Abstract Doc Link 18940901 Disease Relevance 0.72 Pain Relevance 0.15
Tonic muscle nociceptive discharge evoked chemically from the foot extensor digitorum brevis muscle in man produces a depression of Ia excitation and Ib inhibition of the soleus (Sol) motoneurones (Mns).
Negative_regulation (inhibition) of Mns in muscle associated with nociception and depression
14) Confidence 0.36 Published 1999 Journal Brain Res. Section Abstract Doc Link 9914433 Disease Relevance 0.39 Pain Relevance 0.08
These data indicate that the reduced FMD is a good marker for monitoring cardiovascular complications in MCTD.
Negative_regulation (reduced) of FMD associated with systemic sclerosis and increased venous pressure under development
15) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.50 Pain Relevance 0.04
CAD patients showed markedly impaired FMD compared to the non-CAD group (5.7 +/- 4.8 versus 12.6 +/- 6.7%, P < 0.0001) and to controls (5.7 +/- 4.8 versus 15.7 +/- 3.9%, P < 0.00001).
Negative_regulation (impaired) of FMD associated with coronary artery disease and increased venous pressure under development
16) Confidence 0.32 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9069525 Disease Relevance 2.32 Pain Relevance 0.08
On univariate analysis, impaired FMD in CAD patients and non-CAD patients was related to the extent of coronary disease (1-, 2- or 3-vessel disease; r = -0.67, P < 0.0001), to the maximum percent diameter stenosis in one of the major coronary vessels (r = -0.52, P < 0.0001), brachial artery diameter (r = -0.46, P < 0.0001) and plasma cholesterol level (r = -0.34, P < 0.001).
Negative_regulation (impaired) of FMD in vessels associated with pathologic constriction, coronary artery disease, disease, coronary heart disease and increased venous pressure under development
17) Confidence 0.32 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9069525 Disease Relevance 2.51 Pain Relevance 0.07
Since endothelial dysfunction represents an early stage of atherogenesis, the aim of this study was to determine whether impaired FMD amongst other biomarkers of endothelial dysfunction, is characteristic of patients with MCTD.
Spec (whether) Negative_regulation (impaired) of FMD associated with atherosclerosis, systemic sclerosis and increased venous pressure under development
18) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.40 Pain Relevance 0
Decreased percentage FMD and increased IMT was found in patients with MCTD.
Negative_regulation (Decreased) of FMD associated with systemic sclerosis and increased venous pressure under development
19) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.61 Pain Relevance 0.08
Our results indicated that reduced FMD can clearly distinguish MCTD patients from controls and, moreover, MCTD patients with and without cardiovascular events.
Negative_regulation (reduced) of FMD associated with systemic sclerosis and increased venous pressure under development
20) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.68 Pain Relevance 0.08

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