INT68396

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 21
Disease Relevance 7.79
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatocyte 4
liver 1
vessels 1
TRNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 178 99.16 Very High Very High Very High
agonist 40 94.00 High High
anesthesia 21 93.60 High High
cytokine 21 85.20 High High
addiction 1 76.80 Quite High
alcohol 19 64.28 Quite High
fibrosis 2 56.80 Quite High
Disease Link Frequency Relevance Heat
Hepatomegaly 76 99.78 Very High Very High Very High
Sprains And Strains 304 99.68 Very High Very High Very High
INFLAMMATION 178 99.16 Very High Very High Very High
Necrosis 133 98.82 Very High Very High Very High
Injury 115 96.12 Very High Very High Very High
Liver Cancer 1 96.08 Very High Very High Very High
Nephrotoxicity 1 94.16 High High
Body Weight 114 93.52 High High
Toxicity 116 92.00 High High
Atherosclerosis 35 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytochrome P450 (CYP)-dependent metabolism of TRI produces chloral hydrate (CH) and is rate limiting in the ultimate production of trichloro- and/or dichloroacetic acid from TRI.
Gene_expression (production) of TRI
1) Confidence 0.34 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9070354 Disease Relevance 0.28 Pain Relevance 0.13
In diseased vessels, however, cells dominantly express TRI, as a result of which TGF-?
Gene_expression (express) of TRI in vessels
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.46 Pain Relevance 0.06
However, we observed histopathological evidence of hepatocyte proliferation in response to TRI exposure in mPPAR?
Gene_expression (exposure) of TRI in hepatocyte
3) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.50 Pain Relevance 0.03
was activated after TRI exposure in wild-type but not CYP2E1-null mice, which they attributed to a lack of CYP2E1-mediated production of TCA.
Gene_expression (exposure) of TRI
4) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.21 Pain Relevance 0.05
On the other hand, TRI exposure was associated with significant increases in NF?
Gene_expression (exposure) of TRI
5) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.42 Pain Relevance 0.09
Because hepatic ALDH2 protein expression was inhibited by TRI exposure in all three mouse strains, it is an unlikely cause of the decreased urinary levels of TCA in Ppar?
Gene_expression (exposure) of TRI associated with sprains and strains
6) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.19 Pain Relevance 0.05
The most intriguing result of the present study may be that, although TRI exposure induced enzyme levels involved in the ?
Gene_expression (exposure) of TRI
7) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.26 Pain Relevance 0.07
We measured the cell proliferation marker PCNA (Dietrich 1993) to further investigate hepatocyte proliferation in response to TRI exposure and found that PCNA mRNA increased with TRI exposure in mPPAR?
Gene_expression (exposure) of TRI in hepatocyte
8) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.56 Pain Relevance 0
We measured the cell proliferation marker PCNA (Dietrich 1993) to further investigate hepatocyte proliferation in response to TRI exposure and found that PCNA mRNA increased with TRI exposure in mPPAR?
Gene_expression (exposure) of TRI in hepatocyte
9) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.58 Pain Relevance 0
mice must be duly noted, along with differences in TRI-induced changes in mPPAR?
Gene_expression (differences) of TRI
10) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.16 Pain Relevance 0.04
TCA and TCE were detectable in all TRI-exposed mice but were not significantly different between the two TRI exposures within strains.
Gene_expression (detectable) of TRI associated with sprains and strains
11) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.49 Pain Relevance 0
Because we used genetically modified mice with underlying dysregulation and we evaluated very high TRI exposures that proved systemically toxic, our findings may not directly reveal the difference in “human PPAR?
Gene_expression (exposures) of TRI
12) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.18 Pain Relevance 0
With regard to TRI metabolism, urinary TCA levels in Ppar?
Gene_expression (metabolism) of TRI
13) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.43 Pain Relevance 0.03
-null mice exposed to 2,000 ppm TRI (113%) and in hPPAR?
Gene_expression (exposed) of TRI
14) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.34 Pain Relevance 0.03
To clarify the mechanism underlying the lower TCA levels, we measured expression of the ALDH2 protein involved in the metabolism of chloral hydrate to TCA because TRI has been reported to inhibit ALDH expression and activity (Wang et al. 1999); we found that ALDH2 was reduced to the same degree after TRI exposure in all three strains of mice.
Gene_expression (exposure) of TRI associated with sprains and strains
15) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.29 Pain Relevance 0.05
TCA and TCE were detectable in all TRI-exposed mice but were not significantly different between the two TRI exposures within strains.
Gene_expression (exposures) of TRI associated with sprains and strains
16) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.49 Pain Relevance 0
Our finding that hepatocyte necrosis and inflammatory cell infiltrations were comparable after TRI exposure in all three mouse strains suggests that PPAR?
Gene_expression (exposure) of TRI in hepatocyte associated with necrosis, inflammation and sprains and strains
17) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.47 Pain Relevance 0.08
in the liver, but other TRI metabolites do not (Maloney and Waxman 1999).
Gene_expression (metabolites) of TRI in liver
18) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.06 Pain Relevance 0.03
Discrepancies in the nature of the hepatomegaly caused by TRI exposure may reflect differences in exposure routes, duration, or number of animals used in different studies.
Gene_expression (exposure) of TRI associated with hepatomegaly
19) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.66 Pain Relevance 0
mice after TRI exposure.
Gene_expression (exposure) of TRI
20) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.42 Pain Relevance 0.03

General Comments

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