INT68434

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.50
Pain Relevance 7.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gtpbp4) nucleolus (Gtpbp4) nucleus (Gtpbp4)
GTPase activity (Gtpbp4) ribosome biogenesis (Gtpbp4) cytoplasm (Gtpbp4)
Anatomy Link Frequency
primary sensory neurons 1
pineal gland 1
prefrontal 1
central nervous system 1
microglia 1
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 3 100.00 Very High Very High Very High
opioid receptor 3 99.70 Very High Very High Very High
Cannabinoid 10 99.64 Very High Very High Very High
Central nervous system 9 99.52 Very High Very High Very High
Morphine 12 99.36 Very High Very High Very High
Analgesic 6 98.72 Very High Very High Very High
Neurotransmitter 8 98.32 Very High Very High Very High
Hippocampus 8 97.44 Very High Very High Very High
B1 receptor 97 97.28 Very High Very High Very High
tolerance 4 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acute Renal Failure 49 100.00 Very High Very High Very High
Injury 17 100.00 Very High Very High Very High
Epilepsy 1 100.00 Very High Very High Very High
Bordatella Infection 3 99.86 Very High Very High Very High
Nociception 12 99.60 Very High Very High Very High
Diabetes Mellitus 79 99.44 Very High Very High Very High
Apoptosis 37 98.84 Very High Very High Very High
INFLAMMATION 102 96.48 Very High Very High Very High
Convulsion 4 95.44 Very High Very High Very High
Hyperalgesia 75 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For each run, the mean expression levels of target genes were normalized to the mean expression levels of two endogenous reference genes (sep15 and gtpbp4).
Gene_expression (expression) of gtpbp4
1) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 0.17 Pain Relevance 0.17
For each run, the mean expression levels of target genes were normalized to the mean expression levels of two endogenous reference genes (sep15 and gtpbp4).
Gene_expression (expression) of gtpbp4
2) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 0.17 Pain Relevance 0.17
Diabetes did not alter the level of expression of mu opiate receptors and G-protein alpha subunits.
Gene_expression (expression) of G-protein associated with diabetes mellitus and opiate
3) Confidence 0.43 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11495948 Disease Relevance 0.95 Pain Relevance 0.45
Our results indicate that, besides the receptor modification, alteration to the G-protein expression could be a molecular event associated with the development of cannabinoid tolerance.
Gene_expression (expression) of G-protein associated with cannabinoid and tolerance
4) Confidence 0.39 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9073160 Disease Relevance 0 Pain Relevance 0.38
Chronic treatment with a synthetic cannabinoid CP-55,940 alters G-protein expression in the rat central nervous system.
Gene_expression (expression) of G-protein in central nervous system associated with analgesic, cannabinoid and central nervous system
5) Confidence 0.34 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9073160 Disease Relevance 0 Pain Relevance 0.56
Furthermore, this presynaptic inhibition by tandospirone was prevented after treatment with a pertussis toxin-sensitive GTP-binding protein (G-protein) inhibitor, N-ethylmaleimide (at 3 microM for 5 min).
Gene_expression (sensitive) of G-protein associated with bordatella infection
6) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11068021 Disease Relevance 0.10 Pain Relevance 0.41
In order to evaluate the involvement of the stimulatory G-protein (Gs)-related transduction system in the basic mechanisms of epilepsy, we examine the expression levels of Gsalpha mRNA and specific GTP-binding ability in the hippocampus of amygdaloid-kindled rats at various seizure stages.
Gene_expression (expression) of G-protein in hippocampus associated with epilepsy, convulsion and hippocampus
7) Confidence 0.19 Published 2000 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 10803814 Disease Relevance 0.32 Pain Relevance 0.32
Morphine induces short-lived changes in G-protein gene expression in rat prefrontal cortex.
Gene_expression (expression) of G-protein in prefrontal associated with morphine
8) Confidence 0.14 Published 2001 Journal Eur. J. Pharmacol. Section Title Doc Link 11137853 Disease Relevance 0 Pain Relevance 0.49
Taken together, the results obtained using real time RT-PCR suggested that G-protein genes expression levels following the acute administration of morphine between animals with and without inflammation could influence, at least in part, analgesic responsiveness.
Gene_expression (expression) of G-protein associated with inflammation, analgesic and morphine
9) Confidence 0.10 Published 2008 Journal Scand. J. Immunol. Section Abstract Doc Link 18052964 Disease Relevance 0.43 Pain Relevance 1.08
Heterologous expression of transducin, a known chelator of G-protein betagamma subunits, almost completely abolished the neurotransmitter-induced current inhibition.
Gene_expression (expression) of G-protein associated with neurotransmitter
10) Confidence 0.08 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10323308 Disease Relevance 0.10 Pain Relevance 0.42
It is proposed that these allosterically interacting mu and CB1 receptors in the NAc core may represent G-protein coupled heterodimeric receptor complexes.
Gene_expression (represent) of G-protein
11) Confidence 0.06 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806307 Disease Relevance 0 Pain Relevance 1.00
Further studies are needed in order to elaborate the mechanisms of these opioid receptors in regulating G-protein expression in pineal gland.
Gene_expression (expression) of G-protein in pineal gland associated with opioid receptor
12) Confidence 0.04 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10471401 Disease Relevance 0 Pain Relevance 0.41
High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.
Gene_expression (expression) of G-protein in primary sensory neurons associated with injury
13) Confidence 0.03 Published 2003 Journal Mol. Cell. Neurosci. Section Title Doc Link 14550772 Disease Relevance 0.40 Pain Relevance 0.28
Rat acute renal failure model
Gene_expression (model) of acute renal failure associated with acute renal failure
14) Confidence 0.03 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 1.23 Pain Relevance 0.17
This is in accordance with the pro-nociceptive role of many other G-protein coupled-receptors expressed on microglia, including TLR2-4, P2Y12R, CCR2, CX3CR1 [58].


Gene_expression (expressed) of G-protein in microglia associated with nociception
15) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.62 Pain Relevance 1.59

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