INT68443

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Context Info
Confidence 0.12
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 3.54
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (METTL3) methyltransferase activity (METTL3) RNA binding (METTL3)
nucleus (METTL3)
Anatomy Link Frequency
thyroid 1
monocyte 1
METTL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 151 100.00 Very High Very High Very High
mu opioid receptor 10 100.00 Very High Very High Very High
addiction 60 91.12 High High
Neuropathic pain 2 88.04 High High
Opioid 2 86.08 High High
withdrawal 26 84.12 Quite High
nMDA receptor 2 84.12 Quite High
Morphine 2 80.56 Quite High
Endogenous opioid 2 78.20 Quite High
anesthesia 30 77.56 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 22 99.82 Very High Very High Very High
Neuroblastoma 4 98.46 Very High Very High Very High
Thyroid Neoplasm 46 98.32 Very High Very High Very High
Cancer 100 93.96 High High
Systemic Inflammatory Response Syndrome 110 92.24 High High
Esophageal Cancer 65 92.00 High High
Pneumonia 40 89.40 High High
Neuropathic Pain 2 88.04 High High
Disease 30 86.00 High High
Anastomotic Leak 45 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combination of TPA treatment and transcription inhibition with actinomycin D was associated with a transient increase in MuOR mRNA.
Positive_regulation (increase) of MuOR mRNA
1) Confidence 0.12 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.06 Pain Relevance 0
Using a human neuroblastoma cell line, the authors tested the hypothesis that phorbol ester activation of PKC regulates MuOR mRNA levels.
Positive_regulation (activation) of MuOR mRNA associated with neuroblastoma, kinase c and mu opioid receptor
2) Confidence 0.08 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.26 Pain Relevance 0.88
RT-PCR of human monocyte-derived macrophage (HMDM) mRNA showed detectable levels of ENK mRNA at 48 h after plating, followed by PC3 and CPE mRNAs at 72 h.
Positive_regulation (levels) of ENK mRNA in monocyte
3) Confidence 0.03 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
There are some experimental evidence for the phenomenon of a RA-induced increase in Tg mRNA.
Positive_regulation (increase) of mRNA associated with rheumatoid arthritis
4) Confidence 0.01 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.29 Pain Relevance 0.07
Kurebayashi et al. [24] showed an increase of Tg mRNA in human poorly differentiated papillary thyroid carcinoma cell line (KTC-1) after incubation with 1 ?
Positive_regulation (increase) of mRNA in thyroid associated with thyroid neoplasm
5) Confidence 0.01 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2739165 Disease Relevance 0.29 Pain Relevance 0.04
IL-6 mRNA was upregulated in the immediate perioperative period (POD 0, Figure 3a) and gradually decreased at POD 3.
Positive_regulation (upregulated) of mRNA
6) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.32 Pain Relevance 0.14
Upregulation of EGR and NAMPT mRNA at POD 1, 3 and 14 indicates that we should become more clinically astute in the immediate postoperative period.
Positive_regulation (Upregulation) of mRNA
7) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.56 Pain Relevance 0.06
1 mRNA were upregulated at POD 5, then NAMPT, EGR1 and MMP9 mRNA.
Positive_regulation (upregulated) of mRNA
8) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.81 Pain Relevance 0.10
Upregulation of VWF and TGF-ß1 mRNA intraoperatively correlated with mortality (p = 0.0021 and 0.009).
Positive_regulation (Upregulation) of mRNA
9) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.32 Pain Relevance 0.09
POD 1 upregulation of PDGFA, ERG1, and HMGB1 mRNA correlated significantly with worse prognosis.
Positive_regulation (upregulation) of mRNA
10) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.26 Pain Relevance 0.11
and c-myc genes and result in time-dependent increase in the mRNA levels of these genes (Figures 1 &8).
Positive_regulation (increase) of mRNA
11) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.16 Pain Relevance 0.36
mRNA expression and transiently upregulated the mRNA levels of these genes (Figures 1 &5).
Positive_regulation (upregulated) of mRNA
12) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.06
The exposure of PBMCs to PMA resulted in a gradual increase in mRNA levels of hTERT, c-myc and PPAR?
Positive_regulation (increase) of mRNA
13) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.40

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