INT68444

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Context Info
Confidence 0.76
First Reported 1997
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.60
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPE) protein modification process (CPE) extracellular region (CPE)
Golgi apparatus (CPE) plasma membrane (CPE) nucleus (CPE)
Anatomy Link Frequency
monocytes 3
joint 1
alveolar macrophages 1
lung 1
CPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
Stimulus evoked pain 10 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
opioid receptor 3 99.36 Very High Very High Very High
Kappa opioid receptor 3 99.32 Very High Very High Very High
substance P 2 81.84 Quite High
trigger zone 1 73.24 Quite High
headache 7 68.08 Quite High
Pain 113 67.00 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 70 100.00 Very High Very High Very High
Hypersensitivity 10 100.00 Very High Very High Very High
Infection 121 98.88 Very High Very High Very High
Nociception 4 98.56 Very High Very High Very High
Lung Cancer 5 98.16 Very High Very High Very High
Sprains And Strains 52 96.28 Very High Very High Very High
Osteoarthritis 47 94.92 High High
Death 12 91.52 High High
Pain 62 91.28 High High
Disease 38 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PC3, carboxypeptidase E and enkephalin in human monocyte-derived macrophages as a tool for genetic studies.
Gene_expression (Expression) of carboxypeptidase E in monocyte associated with enkephalin
1) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Title Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.30
Undifferentiated human monocytes do not express carboxypeptidase E (CPE), prohormone convertase 3 (PC3/PC1) or proenkephalin (ENK), suggesting that gene induction during differentiation results in the expression of these genes.
Neg (not) Gene_expression (express) of CPE in monocytes
2) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
Undifferentiated human monocytes do not express carboxypeptidase E (CPE), prohormone convertase 3 (PC3/PC1) or proenkephalin (ENK), suggesting that gene induction during differentiation results in the expression of these genes.
Neg (not) Gene_expression (express) of carboxypeptidase E in monocytes
3) Confidence 0.76 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
As CPH requires ongoing peripheral nociceptive input for its perpetuation [53], effectively treating sources of this nociceptive input (i.e., responding to questions #2), would appear to be useful in addressing CPH.
Gene_expression (addressing) of CPH associated with nociception and stimulus evoked pain
4) Confidence 0.59 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1955449 Disease Relevance 1.26 Pain Relevance 0.70
In this study, tissue samples from 12 lung cancer patients undergoing lobectomy or pneumonectomy were examined immunohistochemically for the expression of the opioid network components met-enkephalin, the respective precursor proenkephalin, the key processing enzymes prohormone convertases 1 and 2, carboxypeptidase E, and the delta opioid receptor in different areas of human lung.
Spec (examined) Gene_expression (expression) of carboxypeptidase E in lung associated with lung cancer, opioid receptor, enkephalin and opioid
5) Confidence 0.57 Published 2010 Journal Hum. Pathol. Section Abstract Doc Link 20040394 Disease Relevance 0.17 Pain Relevance 0.74
Its clinical importance is poorly understood at the present time; therefore, the objective of this study was to determine (1) the inter-examiner reliability of detecting CPH and (2) if there is a clinically important correlation (r > 0.4) between the number of cervical spine levels showing signs of degenerative joint disease (DJD) and CPH.


Gene_expression (detecting) of CPH in joint associated with osteoarthritis and hyperplasia
6) Confidence 0.52 Published 2003 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC324408 Disease Relevance 1.12 Pain Relevance 0
Double immunofluorescence microscopy analysis revealed colocalization of the opioid precursor PDYN with its end-product DYN, and key processing enzymes prohormone convertases 1 and 2 and carboxypeptidase E, as well as the kappa-opioid receptor (KOR) within alveolar macrophages and cancerous cells in varying degrees among patients.
Gene_expression (product) of carboxypeptidase E in alveolar macrophages associated with dynorphin, kappa opioid receptor and opioid
7) Confidence 0.41 Published 2010 Journal Histol. Histopathol. Section Abstract Doc Link 20376782 Disease Relevance 0.42 Pain Relevance 0.71
Alphaviruses are known to produce a marked CPE in vertebrate cell cultures [2].
Gene_expression (produce) of CPE
8) Confidence 0.08 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.45 Pain Relevance 0
Less than 5% of the cells express CHIKV antigens at day 2 pi, without any CPE (Figure 4A and 4B).
Neg (without) Gene_expression (express) of CPE
9) Confidence 0.07 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.51 Pain Relevance 0
With hCMEC/D3, only 1% of the cells were CHIKV+ at 24 h pi, this fraction did not increase over time, and no obvious CPE was observed (not shown).
Gene_expression (With) of CPE
10) Confidence 0.07 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.67 Pain Relevance 0

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