INT68445

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 10.80
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ENPP1) extracellular space (ENPP1) small molecule metabolic process (ENPP1)
plasma membrane (ENPP1)
Anatomy Link Frequency
hepatocytes 1
monocytes 1
cartilage 1
melanocytes 1
keratinocytes 1
ENPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 721 99.48 Very High Very High Very High
antagonist 35 91.16 High High
Arthritis 7 91.12 High High
Bile 10 86.72 High High
Enkephalin 3 75.00 Quite High
cytokine 9 65.08 Quite High
Inflammation 21 64.68 Quite High
metalloproteinase 7 63.68 Quite High
melanocortin 1 receptor 2 63.20 Quite High
Inflammatory response 8 59.24 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 735 99.48 Very High Very High Very High
Calcification 588 99.28 Very High Very High Very High
Osteogenic Sarcomas 35 97.96 Very High Very High Very High
Cadaver 14 91.76 High High
Arthritis 7 91.12 High High
Disease 79 84.60 Quite High
Chondrocalcinosis 42 84.28 Quite High
Amputation 21 82.08 Quite High
Crystal Associated Disease 7 80.28 Quite High
Frailty 21 79.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated gene expression of ANKH and ENPP1 causes crystal deposition in cartilage [25,45].
Gene_expression (expression) of ENPP1 in cartilage
1) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.27 Pain Relevance 0.37
In the present study, we found that the expression of several genes implicated in the biomineralization biological process including ENPP1 and ANKH was upregulated in OA meniscal cells.
Gene_expression (expression) of ENPP1 associated with osteoarthritis
2) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.38 Pain Relevance 0.43
We examined and compared the expression of ENPP1 and ANKH in OA meniscal cells and in normal meniscal cells.
Spec (examined) Gene_expression (expression) of ENPP1 associated with osteoarthritis
3) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.32 Pain Relevance 0.31
In the present study, we examined calcium deposition in OA menisci and investigated the expression of several genes implicated in the biomineralization biological process, including ENPP1, ANKH and matrix Gla protein.
Spec (investigated) Gene_expression (expression) of ENPP1 associated with calcification and osteoarthritis
4) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.96 Pain Relevance 0.47
Both microarray and real-time RT-PCR analyses indicated that the expression of ENPP1 and ANKH was upregulated in OA meniscal cells (Table 2).
Gene_expression (expression) of ENPP1 associated with osteoarthritis
5) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.34 Pain Relevance 0.32
100–500), with PCA1.5, PCA80, FM, and GMRE resulting in the most significant results while PCA1, KS and MTS resulted in the least significant associations.
Gene_expression (resulted) of PCA1
6) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941449 Disease Relevance 0.06 Pain Relevance 0
Undifferentiated human monocytes do not express carboxypeptidase E (CPE), prohormone convertase 3 (PC3/PC1) or proenkephalin (ENK), suggesting that gene induction during differentiation results in the expression of these genes.
Neg (not) Gene_expression (express) of PC1 in monocytes
7) Confidence 0.58 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9074629 Disease Relevance 0 Pain Relevance 0.07
We used the top k principal components needed to explain 80% (PCA80) of the variation in the gene expression values within the gene set, along with the methods based on the top one (PCA1) or top five principal components (PCA1.5).
Gene_expression (expression) of PCA1
8) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941449 Disease Relevance 0 Pain Relevance 0
The activities and protein levels of ENPP1, ANKH and matrix Gla protein in OA meniscal cells were not obtained in the present work.
Gene_expression (levels) of ENPP1 associated with osteoarthritis
9) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.53 Pain Relevance 0.46
The expression of several genes involved in biomineralization including ENPP1 and ANKH was upregulated in OA meniscal cells.
Gene_expression (expression) of ENPP1 associated with osteoarthritis
10) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888206 Disease Relevance 1.89 Pain Relevance 0.47
Of the nucleotide pyrophosphatase/phosphodiesterases, NPP1 (PC-1) is expressed on the basolateral membrane of hepatocytes while the closely related NPP3 (B10) has a predominant canalicular in distribution [172, 173].
Gene_expression (expressed) of NPP1 in hepatocytes
11) Confidence 0.18 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.06 Pain Relevance 0.27
Human epidermal keratinocytes and melanocytes express proopiomelanocortins (POMC) and all of the enzymes for POMC processing, i.e. prohormone convertases PC-1 and PC-2 including the regulatory protein 7B2.
Gene_expression (express) of PC-1 in melanocytes
12) Confidence 0.07 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.06
Human epidermal keratinocytes and melanocytes express proopiomelanocortins (POMC) and all of the enzymes for POMC processing, i.e. prohormone convertases PC-1 and PC-2 including the regulatory protein 7B2.
Gene_expression (express) of PC-1 in keratinocytes
13) Confidence 0.02 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914090 Disease Relevance 0 Pain Relevance 0.06

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