INT68447

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Context Info
Confidence 0.64
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 5.69
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDP1) small molecule metabolic process (PDP1)
Anatomy Link Frequency
plasma 2
muscle 2
Notch 1
leg 1
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 113 100.00 Very High Very High Very High
fibrosis 60 98.02 Very High Very High Very High
Inflammation 40 87.04 High High
Angina 1 84.40 Quite High
Bile 15 46.44 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
lidocaine 8 5.00 Very Low Very Low Very Low
Immobilon 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 179 100.00 Very High Very High Very High
Hypertension 61 100.00 Very High Very High Very High
Hypoxia 34 98.24 Very High Very High Very High
Fibrosis 69 98.02 Very High Very High Very High
Cancer 98 97.28 Very High Very High Very High
Exocrine Pancreatic Insufficiency 6 96.32 Very High Very High Very High
Ischemic Heart Disease 4 93.84 High High
Body Weight 65 92.04 High High
INFLAMMATION 40 87.04 High High
Insulin Resistance 32 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, of notice is that marked exercise-induced activation of PDH was still present when plasma FFA was elevated, which suggests that beneficial effects of physical activity include that exercise overrules FFA-mediated inhibition of carbohydrate oxidation.



Positive_regulation (activation) of PDH in plasma
1) Confidence 0.64 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
But at the same time, the present data are also consistent with the previous indications (29,36,37) that PDH activation plays a role in determining the balance between glycolytic/glycogenolytic flux and oxidation.
Positive_regulation (activation) of PDH
2) Confidence 0.64 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
mol/l) indicates that metabolic factors do adjust the exercise-induced activation of PDH.
Positive_regulation (activation) of PDH
3) Confidence 0.64 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.21 Pain Relevance 0
Increases in mitochondrial calcium levels are likely important, since mitochondrial calcium concentration increases during exercise (4,21) and calcium has been shown to activate PDP1 leading to dephosphorylation and activation of PDH (30).
Positive_regulation (activation) of PDH
4) Confidence 0.64 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.11 Pain Relevance 0
Therefore, the observed upregulation of PDHa activity by exercise despite elevated plasma FFA in the present study in accordance with previous findings (26,34,35) supports that a beneficial effect of physical activity may include that FFAs do not prevent exercise-induced PDH activation.
Positive_regulation (activation) of PDH in plasma
5) Confidence 0.64 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.25 Pain Relevance 0
Based on measurements of muscle glucose and muscle glucose-6-phosphate concentrations, the current findings may suggest that glycolytic flux did not entirely determine the PDH activity during exercise.
Neg (not) Spec (determine) Positive_regulation (determine) of PDH in muscle
6) Confidence 0.46 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
In all conditions, exercise increased PDHa (PDH in the active form) activity, resulting in similar levels in LOW leg in both trials and CON leg in high FFA, but higher level in CON leg in low FFA.
Positive_regulation (increased) of PDH in leg
7) Confidence 0.43 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
The activation of PDH by exercise independent of changes in muscle glycogen or plasma FFA suggests that exercise overrules FFA-mediated inhibition of PDH (i.e., carbohydrate oxidation), and this may thus be one mechanism behind the health-promoting effects of exercise.



Positive_regulation (activation) of PDH in muscle
8) Confidence 0.43 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
This can be accomplished by different means, including direct or indirect inhibition of CPT-I or inhibition of fatty acid beta-oxidation, or by direct or indirect activation of PDH.
Positive_regulation (activation) of PDH
9) Confidence 0.38 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9074687 Disease Relevance 0.41 Pain Relevance 0.08
Indeed, amylase and lipase activity in pancreatic fluid progressively decreased after induction of PDH.
Positive_regulation (induction) of PDH associated with hypertension
10) Confidence 0.19 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC3010641 Disease Relevance 0.75 Pain Relevance 0.07
Therefore, we conclude that in the ectatic ducts of CP, PDH activates signalling pathways such as Notch, which have transforming potential.
Positive_regulation (ducts) of PDH in Notch associated with hypertension and chronic pancreatitis
11) Confidence 0.13 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 0.64 Pain Relevance 0.44
Pancreatic fibrosis observed mainly in the intralobular area and especially in the periductal area on day 7 after the induction of PDH further progressed and was markedly distributed in the interlobular or perilobular and intralobular areas on day 14 (Figures 6(a) and 6(b)).
Positive_regulation (induction) of PDH associated with fibrosis and hypertension
12) Confidence 0.13 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC3010641 Disease Relevance 0.93 Pain Relevance 0.15
However, nonenzymatic protein concentration in pancreatic fluid gradually increased during continuous PDH after the initial drop.
Positive_regulation (increased) of PDH associated with hypertension
13) Confidence 0.11 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC3010641 Disease Relevance 0.87 Pain Relevance 0.09
The increase in PDH activity increases oxygen consumption, and hypoxia, in the hypoxic tumor.
Positive_regulation (increase) of PDH associated with cancer and hypoxia
14) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737639 Disease Relevance 1.52 Pain Relevance 0

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