INT68448

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.84
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDP1) small molecule metabolic process (PDP1)
Anatomy Link Frequency
plasma 2
PDP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 84.40 Quite High
fibrosis 20 78.32 Quite High
Inflammation 13 55.52 Quite High
Bile 5 47.08 Quite Low
Chronic pancreatitis 35 35.24 Quite Low
alcohol 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 19 100.00 Very High Very High Very High
Ischemic Heart Disease 8 93.84 High High
Exocrine Pancreatic Insufficiency 2 93.04 High High
Body Weight 20 92.68 High High
Insulin Resistance 4 86.72 High High
Diabetes Mellitus 1 84.48 Quite High
Cv General 3 Under Development 2 84.40 Quite High
Fibrosis 23 78.32 Quite High
Cv Unclassified Under Development 2 76.92 Quite High
INFLAMMATION 13 55.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the observed upregulation of PDHa activity by exercise despite elevated plasma FFA in the present study in accordance with previous findings (26,34,35) supports that a beneficial effect of physical activity may include that FFAs do not prevent exercise-induced PDH activation.
Negative_regulation (prevent) of Positive_regulation (activation) of PDH in plasma
1) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.25 Pain Relevance 0
This can be accomplished by different means, including direct or indirect inhibition of CPT-I or inhibition of fatty acid beta-oxidation, or by direct or indirect activation of PDH.
Negative_regulation (inhibition) of Positive_regulation (activation) of PDH
2) Confidence 0.23 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9074687 Disease Relevance 0.42 Pain Relevance 0.08
This can be accomplished by different means, including direct or indirect inhibition of CPT-I or inhibition of fatty acid beta-oxidation, or by direct or indirect activation of PDH.
Negative_regulation (inhibition) of Positive_regulation (activation) of PDH
3) Confidence 0.23 Published 1997 Journal Cardiovasc. Res. Section Abstract Doc Link 9074687 Disease Relevance 0.42 Pain Relevance 0.08
Indeed, amylase and lipase activity in pancreatic fluid progressively decreased after induction of PDH.
Negative_regulation (decreased) of Positive_regulation (induction) of PDH associated with hypertension
4) Confidence 0.12 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC3010641 Disease Relevance 0.75 Pain Relevance 0.07

General Comments

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