INT68451

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Context Info
Confidence 0.22
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde1b) nucleolus (Pde1b) nucleus (Pde1b)
cytoplasm (Pde1b)
Anatomy Link Frequency
brain 1
Pde1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 9 99.78 Very High Very High Very High
Opioid 6 96.04 Very High Very High Very High
Central nervous system 1 96.00 Very High Very High Very High
excitatory amino acid 2 83.20 Quite High
Glutamate 2 81.36 Quite High
opioid receptor 6 79.36 Quite High
Dynorphin 4 68.16 Quite High
Endogenous opioid 1 65.84 Quite High
antagonist 2 43.60 Quite Low
narcan 3 42.64 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 34.48 Quite Low
INFLAMMATION 44 5.00 Very Low Very Low Very Low
Pulmonary Disease 31 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Vomiting 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PDE1B gene is located on chromosome 12q13.
Localization (located) of PDE1B gene
1) Confidence 0.22 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
These anti-opiate peptides (AOP) are secreted or released into the CNS and produce diverse actions that counterbalance the effects of prolonged opiate exposure.
Localization (secreted) of AOP associated with opiate
2) Confidence 0.10 Published 1999 Journal Peptides Section Abstract Doc Link 10698116 Disease Relevance 0 Pain Relevance 0.54
These anti-opiate peptides (AOP) are secreted or released into the CNS and produce diverse actions that counterbalance the effects of prolonged opiate exposure.
Localization (released) of AOP associated with opiate
3) Confidence 0.10 Published 1999 Journal Peptides Section Abstract Doc Link 10698116 Disease Relevance 0 Pain Relevance 0.54
NO is synthesized from L-arginine by the Ca2+/calmodulin-dependent neuronal isoform NO synthase (NOS) localized in sub-populations of neurons throughout the brain, including the hypothalamus.
Localization (localized) of calmodulin-dependent in brain
4) Confidence 0.07 Published 1997 Journal Endocrinology Section Abstract Doc Link 9075713 Disease Relevance 0 Pain Relevance 0.27

General Comments

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