INT68465

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Context Info
Confidence 0.19
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.35
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal cord 10
heart 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 19 99.76 Very High Very High Very High
nMDA receptor antagonist 4 99.74 Very High Very High Very High
Morphine 22 99.54 Very High Very High Very High
Spinal cord 25 99.12 Very High Very High Very High
narcan 9 97.88 Very High Very High Very High
antagonist 11 96.36 Very High Very High Very High
Glutamate receptor 1 95.92 Very High Very High Very High
Inflammation 40 95.16 Very High Very High Very High
Kinase C 8 89.76 High High
Hyperalgesia 15 89.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 95.16 Very High Very High Very High
Hyperalgesia 20 66.28 Quite High
Morphine Dependence 1 49.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Positive_regulation (activities) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
1) Confidence 0.19 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Positive_regulation (activities) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
2) Confidence 0.19 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Positive_regulation (activities) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
3) Confidence 0.19 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.51 Pain Relevance 0.70
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Positive_regulation (activities) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
4) Confidence 0.19 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.45 Pain Relevance 0.66
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Positive_regulation (activities) of Gene_expression (expression) of protein kinase in spinal cord associated with spinal cord
5) Confidence 0.19 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.50 Pain Relevance 0.70
These results suggest that NMDA receptor antagonists inhibit the increase in protein kinase activity produced by chronic morphine treatment, thus suppressing the naloxone-induced rise in norepinephrine release.
Positive_regulation (increase) of Gene_expression (produced) of protein kinase associated with nmda receptor antagonist, narcan and morphine
6) Confidence 0.08 Published 1997 Journal J Toxicol Sci Section Abstract Doc Link 9076657 Disease Relevance 0 Pain Relevance 1.29
Our previous studies have shown that morphine withdrawal induced an increase in the expression of protein kinase (PK) A and mitogen-activated extracellular kinase (MAPK) pathways in the heart during morphine withdrawal.
Positive_regulation (increase) of Gene_expression (expression) of protein kinase in heart associated with withdrawal and morphine
7) Confidence 0.06 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 0.81

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