INT68466

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.29
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 60 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Kinase C 3 100.00 Very High Very High Very High
cINOD 22 99.98 Very High Very High Very High
Pain 207 99.56 Very High Very High Very High
Hippocampus 1 98.20 Very High Very High Very High
opioid receptor 4 97.96 Very High Very High Very High
opiate 7 97.24 Very High Very High Very High
medulla 7 96.76 Very High Very High Very High
Glutamate receptor 10 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 207 99.56 Very High Very High Very High
Arthritis 189 98.36 Very High Very High Very High
Obesity 6 96.72 Very High Very High Very High
INFLAMMATION 9 93.32 High High
Pheochromocytoma 1 93.32 High High
Morphine Dependence 1 61.04 Quite High
Nociception 17 15.20 Low Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If added before cAMP, NSAIDs impaired PKA activation by the cyclic nucleotide; however, if PKA was first activated by cAMP, NSAIDs were ineffective.
Negative_regulation (impaired) of Positive_regulation (activation) of PKA associated with cinod
1) Confidence 0.57 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.49 Pain Relevance 1.01
These results indicate that inhibition of PKA activation explains NSAIDs-induced decrease in adrenaline-stimulated lipolysis.
Negative_regulation (inhibition) of Positive_regulation (activation) of PKA associated with cinod
2) Confidence 0.42 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391277 Disease Relevance 0.47 Pain Relevance 1.02
The role of PKA was determined by using two compounds that inhibit PKA activation through different mechanisms.
Negative_regulation (inhibit) of Positive_regulation (activation) of PKA
3) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.21 Pain Relevance 0.61
Inhibition of PKA activation decreases pain-related synaptic plasticity
Negative_regulation (Inhibition) of Positive_regulation (activation) of PKA associated with pain
4) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.43 Pain Relevance 0.65
Inhibition of PKA activation decreases pain-related behaviors
Negative_regulation (Inhibition) of Positive_regulation (activation) of PKA associated with pain
5) Confidence 0.31 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.54 Pain Relevance 0.58
This activation of PKA and PKC by chronic morphine treatment was inhibited by infusion of dizocilpine or D(-)-2-amino-5-phosphonopentanoic acid (AP-5), an ionotropic glutamate receptor antagonist, together with morphine.
Negative_regulation (inhibited) of Positive_regulation (activation) of PKA associated with kinase c, antagonist, glutamate receptor and morphine
6) Confidence 0.22 Published 1997 Journal J Toxicol Sci Section Abstract Doc Link 9076657 Disease Relevance 0.06 Pain Relevance 1.45
However, the upregulation of hippocampal PKA activity during morphine withdrawal could be suppressed by re-exposure of morphine but not that of heroin, suggesting a likely underlying mechanism of the differential modulation of LTP by two opiates.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of PKA associated with opiate, withdrawal and morphine
7) Confidence 0.10 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17251910 Disease Relevance 0 Pain Relevance 1.51
Inactivation of cAMP dependent-protein kinase (PKA) with a dominant inhibitory mutant strongly reduced PACAP-stimulated PENK transcription.
Negative_regulation (reduced) of Positive_regulation (Inactivation) of PKA
8) Confidence 0.06 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.09 Pain Relevance 0

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