INT68473

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 2.99
Pain Relevance 8.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
Coc (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 209 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
fluoxetine 11 99.90 Very High Very High Very High
Codeine 15 98.48 Very High Very High Very High
gABA 5 91.60 High High
Dopamine 29 89.44 High High
ketamine 119 89.40 High High
cva 3 86.68 High High
withdrawal 41 85.08 High High
hypoalgesia 1 84.44 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 9 99.20 Very High Very High Very High
Death 7 98.64 Very High Very High Very High
Necrosis 3 97.44 Very High Very High Very High
Convulsion 73 92.16 High High
Attention Deficit Hyperactivity Disorder 4 88.56 High High
Apoptosis 6 88.24 High High
Cv General 3 Under Development 3 86.68 High High
Stress 54 84.64 Quite High
Hypoalagesia 1 84.44 Quite High
Shock 2 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FLU and COC appeared to interact in an additive fashion with this measure.
COC Spec (appeared) Binding (interact) of associated with cocaine and fluoxetine
1) Confidence 0.40 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077591 Disease Relevance 0 Pain Relevance 1.42
In two different open-label, non-randomized comparative studies, both NuvaRing and a 150LNG/30EE COC were associated with minimal effects on hemostatic variables and on lipid profile (Magnusdóttir et al 2004; Tuppurainen et al 2004).
COC Binding (associated) of
2) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504064 Disease Relevance 0.15 Pain Relevance 0.04
Compared with a COC containing 150 ?
COC Binding (Compared) of
3) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504064 Disease Relevance 0.07 Pain Relevance 0.04
Experiment 1 indicated that a conditioned stimulus (CS)--a distinctive environment--which repeatedly had been paired with COC, would substitute for the last COC injection in sustaining the oscillatory effect.
COC Binding (paired) of associated with cocaine
4) Confidence 0.31 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10418787 Disease Relevance 0.17 Pain Relevance 0.63
In this report, in vivo electrophysiological measures were monitored in awake adult male rats in order to investigate alterations of the electrocorticogram (ECoG) resulting from interactions between IBO and cocaine (COC).
COC Binding (interactions) of associated with cocaine
5) Confidence 0.29 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11085337 Disease Relevance 0 Pain Relevance 0.68
CONCLUSIONS: Serious outcomes associated with IC and CoC appear to be mitigated since introduction of alosetron under the RMP.


CoC Binding (associated) of
6) Confidence 0.27 Published 2010 Journal Am. J. Gastroenterol. Section Body Doc Link 20197759 Disease Relevance 0 Pain Relevance 0
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Coc Binding (combinations) of in neurons associated with drug induced neurotoxicity and cocaine
7) Confidence 0.25 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.29 Pain Relevance 0.72
Except for CE, AMPH, and MEPH in the presence of COC, the binding of COC and CE tended to be less with 2,000 nM of each added drug than at lower concentrations of them, presumably because of mass-action displacement of COC and CE at the higher concentration.
COC Binding (binding) of associated with cocaine
8) Confidence 0.24 Published 1997 Journal Ther Drug Monit Section Abstract Doc Link 9263384 Disease Relevance 0 Pain Relevance 1.12
Recently, chemical interactions between heroin (Her) or its metabolite morphine (Mor) and cocaine (Coc) were described, resulting in the formation of strong adducts.
Coc Binding (interactions) of associated with cocaine and morphine
9) Confidence 0.22 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.22 Pain Relevance 0.67
The data show that drug combinations potentiate cortical neurotoxicity and that the mode of co-exposure changes cellular death pathways activated by the drugs, strongly suggesting that chemical interactions occurring in Her:Coc, such as adduct formation, shift cell death mechanisms towards necrosis.
Coc Binding (interactions) of associated with necrosis, drug induced neurotoxicity, death and cocaine
10) Confidence 0.21 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.87 Pain Relevance 0.58
Alterations in toxic effects of high dose COC and MA (Fig. 4)
COC Binding (Alterations) of associated with cocaine
11) Confidence 0.19 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1473192 Disease Relevance 0.30 Pain Relevance 0.55
Variable effects on COC binding were noted for AMPH.
COC Binding (binding) of associated with cocaine
12) Confidence 0.18 Published 1997 Journal Ther Drug Monit Section Abstract Doc Link 9263384 Disease Relevance 0 Pain Relevance 1.18
The effect of amphetamine (AMPH), codeine (COD), methamphetamine (MEPH), morphine (MORP), and benzoylecgonine (BE) on the binding of cocaethylene (CE) and cocaine (COC) to human serum in vitro was investigated by equilibrium dialysis at 4 degrees C.
COC Binding (binding) of associated with cocaine, morphine and codeine
13) Confidence 0.18 Published 1997 Journal Ther Drug Monit Section Abstract Doc Link 9263384 Disease Relevance 0 Pain Relevance 1.03
COC, cocaine; BIC, bicuculline; DMCM, methyl 6,7-dimethoxy-4-ethyl-?
COC Binding (bicuculline) of associated with cocaine
14) Confidence 0.07 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137594 Disease Relevance 0.30 Pain Relevance 0.24
COC can also lead to a decrease in circulating albumin levels, leading to a decrease in dehydroepiandrosterone sulphate (DHEAS), which is strongly bound to albumin (Carlstrom et al 2002) and androgen production (Vrbikova and Cibula 2005) and a decrease in peripheral androgen production through an inhibition of 5?
COC Binding (lead) of
15) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504056 Disease Relevance 0.62 Pain Relevance 0

General Comments

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