INT6848

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 17.19
Pain Relevance 20.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
Anatomy Link Frequency
NG108-15 2
BHK 2
endothelial cells 2
fibroblasts 1
uterine 1
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 886 100.00 Very High Very High Very High
Pain 320 100.00 Very High Very High Very High
Inflammation 262 100.00 Very High Very High Very High
B1 receptor 170 100.00 Very High Very High Very High
b2 receptor 168 100.00 Very High Very High Very High
antagonist 58 100.00 Very High Very High Very High
acular 210 99.50 Very High Very High Very High
agonist 62 97.76 Very High Very High Very High
aspirin 22 97.76 Very High Very High Very High
Analgesic 22 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 340 100.00 Very High Very High Very High
INFLAMMATION 272 100.00 Very High Very High Very High
Osteogenic Sarcomas 2 99.44 Very High Very High Very High
Disease 28 99.32 Very High Very High Very High
Arthropathy 1 99.32 Very High Very High Very High
Injury 324 99.28 Very High Very High Very High
Inflammatory Bowel Disease 11 99.20 Very High Very High Very High
Pancreatic Cancer 6 97.56 Very High Very High Very High
Cancer 10 97.00 Very High Very High Very High
Rheumatoid Arthritis 35 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease.
Gene_expression (expression) of B2R in bowel associated with inflammation
1) Confidence 0.75 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15805101 Disease Relevance 1.38 Pain Relevance 0.67
Cell-surface organization of the receptor was assessed by immunoprecipitation and Western blot analysis in CHO-K1 cells expressing N-terminally V5-tagged B2 receptor.
Gene_expression (expressing) of B2 receptor associated with b2 receptor
2) Confidence 0.75 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.36 Pain Relevance 1.03
We hypothesized that kinins autoregulate B2R and B1R expression in favor of B1R.
Gene_expression (expression) of B2R
3) Confidence 0.74 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.28 Pain Relevance 0.77
The correlation between the sum of pain intensity scores as measured by VAS and the up-regulation of gene expression of BDKRB1 and BDKRB2 following tissue injury was examined using Pearson's correlation coefficients (Fig. 2 b-e).
Gene_expression (expression) of BDKRB2 associated with pain and injury
4) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.87 Pain Relevance 1.26
In the present study, we did not see a correlation between B2 receptor and TRPV1 gene expression.
Gene_expression (expression) of B2 receptor associated with b2 receptor
5) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.63 Pain Relevance 0.72
Inflammatory cells such as mast cells also, shows expression of B1 and B2 receptor [38].
Gene_expression (expression) of B2 receptor in mast cells associated with inflammation and b2 receptor
6) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 0.66
Further, B1 and B2 receptor genes are expressed in gingival fibroblasts [37].
Gene_expression (expressed) of B2 receptor in fibroblasts associated with b2 receptor
7) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.66 Pain Relevance 0.69
In this study, human B2R was expressed at high levels in baby hamster kidney (BHK) cells using Semliki Forest virus-based vectors.
Gene_expression (expressed) of B2R in BHK
8) Confidence 0.72 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.20 Pain Relevance 0.34
Biochemical and pharmacological characterization of the human bradykinin subtype 2 receptor produced in mammalian cells using the Semliki Forest virus system.
Gene_expression (produced) of bradykinin subtype 2 receptor associated with bradykinin
9) Confidence 0.72 Published 2006 Journal Biol. Chem. Section Title Doc Link 16740128 Disease Relevance 0.17 Pain Relevance 0.34
In a Southern blot analysis following reverse transcription and polymerase chain reaction, the human B2 receptor was found to be expressed in most human tissues.
Gene_expression (expressed) of B2 receptor associated with b2 receptor
10) Confidence 0.67 Published 1994 Journal Genomics Section Abstract Doc Link 7835885 Disease Relevance 0.17 Pain Relevance 0.35
The effect of aspirin on bradykinin binding to cell-surface receptor and on signal transduction were studied in CHO-K1 cells, stably expressing the human B2 receptor.
Gene_expression (expressing) of B2 receptor associated with aspirin, b2 receptor and bradykinin
11) Confidence 0.65 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18355801 Disease Relevance 0.36 Pain Relevance 0.90
Incorporation of this group resulted in a series of derivatives ((S)-14d,e and 19b-d) with K(i) ranges of 10.7-176 nM in NG108-15 cells (expressing the rodent B2 receptor) and 0.79-253 nM in Cos-7 cells (expressing the human B2 receptor).
Gene_expression (expressing) of B2 receptor in NG108-15 associated with b2 receptor
12) Confidence 0.65 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 12014954 Disease Relevance 0.27 Pain Relevance 0.81
Incorporation of this group resulted in a series of derivatives ((S)-14d,e and 19b-d) with K(i) ranges of 10.7-176 nM in NG108-15 cells (expressing the rodent B2 receptor) and 0.79-253 nM in Cos-7 cells (expressing the human B2 receptor).
Gene_expression (expressing) of B2 receptor in NG108-15 associated with b2 receptor
13) Confidence 0.65 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 12014954 Disease Relevance 0.27 Pain Relevance 0.81
Moreover, B2 receptors (B2R), which mediate the action of BK and KD, participates in the acute stage of the inflammatory and pain response, whereas B1 receptors (B1R), through which desArg(9)BK and desArg(10)KD act, partake in the chronic stage.
Gene_expression (partake) of B2R associated with pain, inflammation and bradykinin
14) Confidence 0.64 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.30 Pain Relevance 0.77
To the best of our knowledge, this is the first report of an affinity-tagged recombinant B2R been expressed at high levels in BHK cells and extensively characterized.
Gene_expression (expressed) of B2R in BHK
15) Confidence 0.63 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.12 Pain Relevance 0.23
It is generally accepted that the B2 receptor is constitutively expressed, whereas the B1 receptor is induced in response to inflammation.
Gene_expression (expressed) of B2 receptor associated with inflammation, b1 receptor and b2 receptor
16) Confidence 0.56 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 0.92 Pain Relevance 0.61
Correlation between the gene expression of BDKRB1, BDKRB2, TRPV1 and NF?
Gene_expression (expression) of BDKRB2
17) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.33 Pain Relevance 0.40
Effect of tissue injury and ketorolac treatment on BDKRB1 and BDKRB2 gene expression at the site of tissue injury
Gene_expression (expression) of BDKRB2 associated with injury and acular
18) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.62 Pain Relevance 0.73
Interestingly, the change in gene expression of TRPV1 was correlated to the change in gene expression of B1 receptor but not B2 receptor.


Gene_expression (expression) of B2 receptor associated with b1 receptor and b2 receptor
19) Confidence 0.56 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 0.90 Pain Relevance 0.72
Ketorolac treatment did not have a significant effect on the gene expression of either BDKRB1 (p = 0.71; unpaired t-test) or BDKRB2 (p = 0.73; unpaired t-test).

3.

Gene_expression (expression) of BDKRB2 associated with acular
20) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.74 Pain Relevance 1.15

General Comments

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