INT68486

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Context Info
Confidence 0.20
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 0.19
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
fibroblasts 1
HSF 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 4 98.00 Very High Very High Very High
cINOD 2 96.96 Very High Very High Very High
dexamethasone 25 88.88 High High
corticosteroid 121 86.40 High High
Endogenous opioid 1 74.52 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 96.68 Very High Very High Very High
Insulin Resistance 100 50.00 Quite Low
Diabetes Mellitus 25 5.00 Very Low Very Low Very Low
Exsanguination 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Frailty 10 5.00 Very Low Very Low Very Low
Metabolic Syndrome 10 5.00 Very Low Very Low Very Low
Repression 5 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To examine the effect of 2 nonsteroidal antiinflammatory drugs (NSAIDs), nimesulide (NIM), a preferential cyclooxygenase 2 (COX-2) inhibitor, and naproxen (NAP), on the functional parameters and transcriptional activity of the glucocorticoid receptor (GR) system in cultured human synovial fibroblasts (HSF).
Transcription (activity) of glucocorticoid receptor in HSF associated with inflammation, cinod and cox2
1) Confidence 0.20 Published 1999 Journal Arthritis Rheum. Section Abstract Doc Link 9920026 Disease Relevance 0.10 Pain Relevance 0.18
Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor.
Transcription (activity) of glucocorticoid receptor in fibroblasts associated with cox2
2) Confidence 0.20 Published 1999 Journal Arthritis Rheum. Section Title Doc Link 9920026 Disease Relevance 0.09 Pain Relevance 0.19
The IC50_Rm was estimated at 0.911 fmol/mg protein, suggesting GR mRNA transcription is sensitive to the inhibition by steroid treatment.
Transcription (transcription) of GR
3) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.07
The GR mRNA concentration drops from the baseline level to the trough in 10 h and then slowly returns to the baseline.
Transcription (concentration) of GR
4) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
where GR0mRNA and GR0 are the baseline levels of GR mRNA and free cytosolic GR at time zero.
Transcription (levels) of GR
5) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.04
where GR0mRNA and GR0 are the baseline levels of GR mRNA and free cytosolic GR at time zero.
Transcription (levels) of GR
6) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.04
where GR0mRNA and GR0 are the baseline levels of GR mRNA and free cytosolic GR at time zero.
Transcription (levels) of GR0
7) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.04
Although the numbers of GR change with gestation, the relative abundance of GR mRNA does not, pointing to post-translational regulatory mechanisms.
Transcription (abundance) of GR
8) Confidence 0.03 Published 1993 Journal Equine Vet J Suppl Section Abstract Doc Link 9079135 Disease Relevance 0 Pain Relevance 0.12

General Comments

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