INT6849

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Context Info
Confidence 0.81
First Reported 1986
Last Reported 2011
Negated 3
Speculated 11
Reported most in Abstract
Documents 229
Total Number 240
Disease Relevance 112.56
Pain Relevance 69.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 27
macrophages 11
endothelial cells 6
blood 6
microglia 6
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2620 100.00 Very High Very High Very High
cytokine 1608 100.00 Very High Very High Very High
agonist 843 100.00 Very High Very High Very High
Inflammatory mediators 109 100.00 Very High Very High Very High
nociceptor 20 100.00 Very High Very High Very High
cINOD 161 99.92 Very High Very High Very High
substance P 154 99.92 Very High Very High Very High
Potency 26 99.92 Very High Very High Very High
dexamethasone 184 99.84 Very High Very High Very High
rheumatoid arthritis 965 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3051 100.00 Very High Very High Very High
Cancer 347 100.00 Very High Very High Very High
Necrosis 179 100.00 Very High Very High Very High
Anaemia 37 100.00 Very High Very High Very High
Hypoxia 4 100.00 Very High Very High Very High
Apoptosis 319 99.88 Very High Very High Very High
Temporomandibular Joint Disorders 3 99.88 Very High Very High Very High
Amyloid Plaque 23 99.84 Very High Very High Very High
Rheumatoid Arthritis 979 99.76 Very High Very High Very High
Hemorrhage 28 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Interleukin-1 beta was predominantly localized in the synovial lining cells and endothelial cells of blood vessels.
Localization (localized) of Interleukin-1 beta in lining cells
1) Confidence 0.81 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10519747 Disease Relevance 0.16 Pain Relevance 0
On the other hand, endogeneous IL-1, secreted in response to disease or stress, may alter the endogenous opioid pathway by inducing the expression of opioid receptors in endothelial cells.
Localization (secreted) of IL-1 in endothelial cells associated with stress, endogenous opioid, opioid receptor and disease
2) Confidence 0.80 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 9666258 Disease Relevance 0.20 Pain Relevance 0.79
Suppressive effect of anti-rheumatic drugs on interleukin-1 beta release from human peripheral blood monocytes.
Localization (release) of interleukin-1 beta in monocytes
3) Confidence 0.80 Published 1991 Journal Int. J. Immunopharmacol. Section Title Doc Link 2026474 Disease Relevance 0.09 Pain Relevance 0.13
Secreted IL-1 beta represented 31 to 86% of the total IL-1 beta.
Localization (Secreted) of IL-1 beta
4) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.22 Pain Relevance 0.11
More IL-1 alpha than IL-1 beta was produced but, unlike IL-1 beta, IL-1 alpha was poorly secreted.
Localization (secreted) of IL-1
5) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.22 Pain Relevance 0.15
D-Penicillamine (up to 6 mM), cyclosporin A (up to 1 microM) and methotrexate (up to 12 microM) inhibited neither cell-associated nor secreted IL-1 beta levels.
Localization (secreted) of IL-1 beta associated with methotrexate
6) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.09 Pain Relevance 0.27
Nordihydroguaiaretic acid inhibited the level of the secreted form of IL-1 beta, but tended to increase the cell-associated level.
Localization (secreted) of IL-1 beta
7) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.21 Pain Relevance 0.28
The mean total IL-1 beta (cell-associated and secreted) production in 18 different donors was 11 ng/10(6) cells (range 1.2-28.8).
Localization (secreted) of IL-1 beta
8) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.22 Pain Relevance 0.11
More IL-1 alpha than IL-1 beta was produced but, unlike IL-1 beta, IL-1 alpha was poorly secreted.
Localization (secreted) of IL-1 beta
9) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.22 Pain Relevance 0.15
IL-1 beta and alpha biosynthesis was stimulated with LPS, and cell-associated and secreted IL-1 beta and IL-1 alpha were measured by specific immunoassays (ELISA).
Localization (secreted) of IL-1 beta
10) Confidence 0.80 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.18 Pain Relevance 0.08
ATP at concentrations > or = 2 mM promoted IL-1 beta release from these cells.
Localization (release) of IL-1
11) Confidence 0.80 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.23 Pain Relevance 0.26
The ATP-induced release and maturation of IL-1 beta from human monocytes and macrophages, therefore, was suppressed by anion transport inhibitors, suggesting that anion conductance is a necessary component of the ATP-promoted externalization mechanism.
Localization (release) of IL-1 in macrophages
12) Confidence 0.80 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.20 Pain Relevance 0.29
In the absence of a secondary stimulus, however, little IL-1 beta is released into the medium.
Localization (released) of IL-1
13) Confidence 0.80 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.24 Pain Relevance 0.15
Previously, ATP was shown to promote the release and proteolytic maturation of IL-1 beta from LPS-stimulated murine peritoneal macrophages.
Localization (release) of IL-1 in peritoneal macrophages
14) Confidence 0.80 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.25 Pain Relevance 0.19
A second effect of SKF86002 was to inhibit release of IL-1 beta into the medium in response to high concentrations of LPS; this effect is observed only with freshly isolated human monocytes as other IL-1 beta-producing cells do not release significant cytokine in response to LPS.
Localization (release) of IL-1 in monocytes associated with cytokine
15) Confidence 0.79 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7565623 Disease Relevance 0 Pain Relevance 0.23
Inflammatory and chemoattractant mediators likely promote phagocytosis of trauma-induced cellular debris by macrophages and these cells can continue to secrete IL-1?
Localization (secrete) of IL-1 in macrophages associated with inflammation and injury
16) Confidence 0.78 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.93 Pain Relevance 0.21
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Localization (release) of IL-1beta in monocytes
17) Confidence 0.78 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.26
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Localization (release) of IL-1beta in monocytes
18) Confidence 0.78 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
We conclude that, in vivo, intraperitoneal LPS lowers visceral pain threshold (allodynia) through a mechanism involving mast cell degranulation and IL-1beta and TNF-alpha release and that the vagus nerve may exert a tonic protective role against LPS-induced rectal allodynia.
Localization (release) of IL-1beta in mast cell associated with pain threshold, allodynia and vagus nerve
19) Confidence 0.78 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11005766 Disease Relevance 0.37 Pain Relevance 0.47
We investigated the hypothesis that oral clonidine premedication would decrease the release of proinflammatory cytokines interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha, and stress hormones cortisol and adrenocorticotropic hormone (ACTH), in patients who underwent total abdominal hysterectomy.
Localization (release) of IL-1beta associated with stress, necrosis, cancer, cytokine and clonidine
20) Confidence 0.78 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10825337 Disease Relevance 0.30 Pain Relevance 0.34

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