INT68496

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 16.36
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
body 2
myometrium 1
superior 1
endometrium 1
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 53 100.00 Very High Very High Very High
aspirin 30 100.00 Very High Very High Very High
antagonist 124 99.72 Very High Very High Very High
agonist 75 96.80 Very High Very High Very High
Inflammation 84 92.76 High High
Somatostatin 2 92.72 High High
tolerance 7 85.96 High High
withdrawal 6 85.20 High High
palliative 3 83.76 Quite High
antiepileptic Drug 19 67.68 Quite High
Disease Link Frequency Relevance Heat
Tungiasis 74 100.00 Very High Very High Very High
Cancer 444 99.92 Very High Very High Very High
Breast Cancer 241 99.60 Very High Very High Very High
Inflammatory Breast Neoplasms 268 99.54 Very High Very High Very High
Sarcoma 71 99.48 Very High Very High Very High
Disease 81 99.44 Very High Very High Very High
Erythema 7 96.48 Very High Very High Very High
Bundle-branch Block 1 96.16 Very High Very High Very High
Leishmaniasis 55 96.14 Very High Very High Very High
Reprotox - General 1 62 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antiprogestogens, which block the action of progesterone at the cellular level through binding to the progesterone receptor, are proving to be one of the most significant developments in endocrinology in recent years.
progesterone receptor Binding (binding) of
1) Confidence 0.48 Published 1995 Journal Hum. Reprod. Update Section Abstract Doc Link 9080204 Disease Relevance 0 Pain Relevance 0
It has moderate affinity for the progesterone receptor, significant antiproliferative and antiandrogenic activity, and produces secretory transformation of the endometrium.
progesterone receptor Binding (affinity) of in endometrium
2) Confidence 0.36 Published 2002 Journal Drugs Section Abstract Doc Link 11827562 Disease Relevance 0 Pain Relevance 0
The PR of tungiasis showed no significant association at the beginning of the intervention in November 2002 (PR?
PR Binding (intervention) of associated with tungiasis
3) Confidence 0.32 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2565488 Disease Relevance 0.32 Pain Relevance 0
The PR of tungiasis showed no significant association at the beginning of the intervention in November 2002 (PR?
PR Neg (no) Binding (association) of associated with tungiasis
4) Confidence 0.32 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2565488 Disease Relevance 0.33 Pain Relevance 0
With all the techniques applied, the three cell lines were found to be negative for both ER and PR.
PR Binding (negative) of
5) Confidence 0.31 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.58 Pain Relevance 0.08
Estrogen receptor (ER) and progesterone receptor (PR) were both negative.



progesterone receptor Binding (negative) of
6) Confidence 0.31 Published 1997 Journal HPB Surg Section Abstract Doc Link PMC2423885 Disease Relevance 0.87 Pain Relevance 0.11
Estrogen receptor (ER) and progesterone receptor (PR) were both negative.



PR Binding (negative) of
7) Confidence 0.31 Published 1997 Journal HPB Surg Section Abstract Doc Link PMC2423885 Disease Relevance 0.86 Pain Relevance 0.11
Binding of progesterone to PGR-B results in activation of progesterone-responsive genes, however in myometrial cells the action of PGR-B is antagonised by PGR-A which acts as a dominant repressor of transcription [21].
PGR Binding (Binding) of
8) Confidence 0.29 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.06 Pain Relevance 0.08
PGR-C reside mainly in the cytosol of myometrial cells and it is thought that the increase in PGR-C/PGR-B ratio takes progesterone away from PGR-B leading to low PGR binding to nuclear chromatin in myometrium in labour [24,25].
PGR Binding (binding) of in myometrium
9) Confidence 0.26 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.08 Pain Relevance 0.03
A TMA study [51], using tumour samples from 200 breast cancer patients, was conducted that focused on HDAC-1 and HDAC-3, from HDAC class I, since these play a role in proliferation and cell survival of mammary tumour cells and can interact either directly or indirectly with the steroid hormone receptors ER and PGR as well as the tumour suppressor p53 52-54.
PGR Binding (interact) of associated with cancer and breast cancer
10) Confidence 0.23 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.53 Pain Relevance 0
It is the natural ligand of the progesterone receptor (PR), which is expressed in various tissues in the body, predominantly in the reproductive tract.
PR Binding (ligand) of in body
11) Confidence 0.23 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 0 Pain Relevance 0.11
The molecular mechanism of tissue selectivity of steroid receptor modulators has been recently proposed based on the ability of a liganded PR to interact with different coregulators depending on the specific ligand [42-45].
PR Binding (interact) of
12) Confidence 0.23 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 0.52 Pain Relevance 0.09
It is the natural ligand of the progesterone receptor (PR), which is expressed in various tissues in the body, predominantly in the reproductive tract.
progesterone receptor Binding (ligand) of in body
13) Confidence 0.23 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 0 Pain Relevance 0.11
Future research on topical PR in treatment of the old world CL merits addressing the following issues: examining the efficacy of various topical PR regimens in other species, such as L.tropica; comparison between topical PR with MBCL and topical PR only; evaluation of topical PR with different MBCL concentration for their efficacy and tolerability; and development of new formulations that has similar or superior efficacy and better tolerability than topical PR and MBCL.


PR Binding (evaluation) of in superior associated with leishmaniasis
14) Confidence 0.22 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2637543 Disease Relevance 0.29 Pain Relevance 0
The PAs either favor interaction of PR with corepressors or inhibit interactions with coactivators, whereas "pure" PR agonists promote the interaction of the nuclear receptor with coactivators [50,51].
PR Binding (interaction) of associated with antagonist and agonist
15) Confidence 0.22 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 0.23 Pain Relevance 0.14
A third patient with gastric stromal sarcoma, who did not meet RECIST criteria for PR, achieved a 37% reduction in tumor size and stable disease for 20 weeks.
PR Neg (not) Binding (criteria) of associated with sarcoma, cancer and disease
16) Confidence 0.17 Published 2010 Journal Core evidence Section Body Doc Link PMC2899778 Disease Relevance 1.71 Pain Relevance 0
These therapeutic effects have been ascribed to the progestin component of the patch, which interacts selectively with the progesterone receptor and, therefore, does not stimulate androgen receptors (White et al 2005).
progesterone receptor Binding (interacts) of
17) Confidence 0.16 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770395 Disease Relevance 0.92 Pain Relevance 0.11
We did not observe a significant interaction between ever aspirin use, ever NSAID use, and the variant C allele of COX-2 .8473 in ER/PR-negative breast cancer, perhaps because of limited power (Table 4).
PR Neg (not) Binding (interaction) of associated with aspirin, breast cancer and cinod
18) Confidence 0.08 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797023 Disease Relevance 0.83 Pain Relevance 0.69
Interestingly, over-expression of PSE gene had statistically significant association with ER-positive and PR-positive tumors (p = 0.0123 and p = 0.0134, respectively) and showed a trend towards pathology-negative nodal status (31% vs. 19%; Table 3).
PR Binding (association) of associated with cancer
19) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.42 Pain Relevance 0
Type I cancer is associated with hyperestrogenic risk factors, is more often estrogen and progesterone receptor positive, microsatellite unstable, and displays mutations in KRAS or PTEN.
progesterone receptor Binding (associated) of associated with cancer
20) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 1.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox