INT6850

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 15.91
Pain Relevance 16.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle cells 2
salivary glands 2
retina 1
L929 1
impression 1
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
b2 receptor 360 100.00 Very High Very High Very High
antagonist 89 100.00 Very High Very High Very High
Pain 342 99.80 Very High Very High Very High
Nicotine 768 99.68 Very High Very High Very High
Inflammation 484 99.52 Very High Very High Very High
bradykinin 908 99.22 Very High Very High Very High
Eae 154 98.94 Very High Very High Very High
nociceptor 44 98.64 Very High Very High Very High
Analgesic 24 98.44 Very High Very High Very High
dexamethasone 88 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 364 99.80 Very High Very High Very High
Disease 128 99.60 Very High Very High Very High
Arthropathy 1 99.60 Very High Very High Very High
INFLAMMATION 509 99.52 Very High Very High Very High
Immunization 21 99.36 Very High Very High Very High
Injury 386 98.94 Very High Very High Very High
Inflammatory Pain 143 98.94 Very High Very High Very High
Nociception 32 98.82 Very High Very High Very High
Salivary Gland Disease 154 97.52 Very High Very High Very High
Ganglion Cysts 4 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of genes coding kininogen, B1 and B2 receptors can be a very sensitive marker of tissue pathology.
Gene_expression (expression) of B1
1) Confidence 0.46 Published 2001 Journal Ginekol. Pol. Section Abstract Doc Link 11757483 Disease Relevance 0.18 Pain Relevance 0.26
Several B1 and B2 receptor antagonists are being synthesized in an attempt to study the molecular functions of kinins in inflammatory processes (RA, periodontitis and osteomyelitis), and they represent and important area for continued research in rheumatology.
Gene_expression (synthesized) of B1 associated with osteomyelitis, periodontitis, inflammation, antagonist and b2 receptor
2) Confidence 0.39 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.61 Pain Relevance 0.81
Several B1 and B2 receptor antagonists are being synthesized in an attempt to study the molecular functions of kinins in inflammatory processes, such as rheumatoid arthritis, periodontitis, inflammatory diseases of the gut and osteomyelitis.
Gene_expression (synthesized) of B1 in gut associated with osteomyelitis, periodontitis, inflammation, antagonist, rheumatoid arthritis, b2 receptor and disease
3) Confidence 0.36 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 1.60 Pain Relevance 0.83
DESIGN: In the present study, the analysis of expression of genes coding kininogen, B1 and B2 was performed.
Gene_expression (expression) of B1
4) Confidence 0.36 Published 2001 Journal Ginekol. Pol. Section Body Doc Link 11757483 Disease Relevance 0 Pain Relevance 0
Inflammatory cells such as mast cells also, shows expression of B1 and B2 receptor [38].
Gene_expression (expression) of B1 in mast cells associated with inflammation and b2 receptor
5) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 0.66
Further, B1 and B2 receptor genes are expressed in gingival fibroblasts [37].
Gene_expression (expressed) of B1 in fibroblasts associated with b2 receptor
6) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.66 Pain Relevance 0.70
Regulation of B1 expression by B2 receptor through activation of NF?
Gene_expression (expression) of B1 associated with b2 receptor
7) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.50 Pain Relevance 0.99
Most of the earlier studies of acute inflammatory pain focused on BK and KD due to the impression that the B1 receptors are only expressed in chronic inflammation [29].
Gene_expression (expressed) of B1 in impression associated with inflammation, eae and bradykinin
8) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.72 Pain Relevance 0.63
In experimental studies, the expression of B1 receptors has been reported to occur in response to the B1 ligand Lys-des-Arg9-BK [12] and inflammatory cytokines such as IL-1?
Gene_expression (expression) of B1 associated with inflammation, bradykinin and cytokine
9) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.48 Pain Relevance 1.05
While the present data shows only the gene expression of kinin receptors due to limited biopsy size, a correlation between B1 gene expression level and functional up-regulation of the receptor has been reported earlier in LPS treated rats [15].
Gene_expression (expression) of B1
10) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.93 Pain Relevance 1.06
The similar correlation between B1 expression and pain intensity points to the participation of B1 receptor in pain processes at this early time point (3 hours) in contrast to earlier reports [16] confining the contribution of B1 receptors to nociception to later time points.
Gene_expression (expression) of B1 associated with nociception, pain and b1 receptor
11) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 1.04 Pain Relevance 1.18
B is a critical step in up-regulation of B1 receptors that are induced not only by IL-1?
Gene_expression (receptors) of B1
12) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.53 Pain Relevance 0.41
Tissue injury resulted in a significant up-regulation in the gene expression of B1 and B2 receptors at 3 hours post-surgery, the onset of acute inflammatory pain.
Gene_expression (expression) of B1 associated with eae and injury
13) Confidence 0.26 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 1.22 Pain Relevance 0.86
Further, the gene expression of both B1 and B2 receptors were correlated.
Gene_expression (expression) of B1
14) Confidence 0.26 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 1.20 Pain Relevance 0.95
Interestingly, the up-regulation in the gene expression of B1 and B2 receptors was positively correlated to pain intensity only after ketorolac treatment, signifying an interaction between prostaglandins and kinins in the inflammatory pain process.
Gene_expression (expression) of B1 associated with pain, eae and acular
15) Confidence 0.26 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2834653 Disease Relevance 1.26 Pain Relevance 0.87
Whilst both have been implicated in nociception, it is believed that there is a low level of constitutive expression of B1 receptors and that their expression is induced by inflammation or tissue damage.
Gene_expression (expression) of B1 associated with nociception and inflammation
16) Confidence 0.08 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025959 Disease Relevance 0.43 Pain Relevance 0.25
Whilst both have been implicated in nociception, it is believed that there is a low level of constitutive expression of B1 receptors and that their expression is induced by inflammation or tissue damage.
Gene_expression (expression) of B1 associated with nociception and inflammation
17) Confidence 0.07 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025959 Disease Relevance 0.43 Pain Relevance 0.25
Effects of nicotine on airway kinin B1 and B2 receptor mRNA and protein expressions
Gene_expression (expressions) of B1 associated with nicotine and b2 receptor
18) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.44
In the control segments, the expression of B1 receptors is higher in the epithelial cells compared to the smooth muscle cells; while after nicotine treatment, the increase in B1 receptor protein expression was more prominent in the smooth muscle cells than in the epithelial cells (Fig. 5E).
Gene_expression (expression) of B1 in smooth muscle cells associated with b1 receptor and nicotine
19) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.38
The increase in B1 and B2 receptor mRNA and protein expression after organ culture with nicotine strengthens the evidence for an alteration at the receptor level rather than a down-stream process.
Gene_expression (expression) of B1 associated with nicotine and b2 receptor
20) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.19 Pain Relevance 0.43

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