INT68505

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.26
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
blood 2
skin 2
platelet 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 17 100.00 Very High Very High Very High
COX2 7 100.00 Very High Very High Very High
Endocannabinoid 7 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
analgesia 1 97.68 Very High Very High Very High
IPN 1 94.60 High High
Antinociceptive 2 93.68 High High
Potency 4 92.00 High High
Acute pain 1 85.68 High High
Osteoarthritis 1 84.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 98.72 Very High Very High Very High
Cutaneous Melanoma 2 98.60 Very High Very High Very High
Metastasis 3 98.04 Very High Very High Very High
Thrombosis 1 94.72 High High
Inflammatory Pain 1 94.60 High High
Skin Cancer 1 92.08 High High
Pressure And Volume Under Development 2 90.72 High High
Cancer 1 89.40 High High
Hyperalgesia 7 77.52 Quite High
Ulcers 3 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observations indicate that the inhibition of cyclooxygenase-2 can lead to the regression of disseminated skin melanoma metastases, even after failure of chemotherapy.
Positive_regulation (lead) of Negative_regulation (inhibition) of cyclooxygenase-2 in skin associated with cutaneous melanoma and metastasis
1) Confidence 0.49 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16718274 Disease Relevance 0.71 Pain Relevance 0.09
Mechanisms by which cyclooxygenase-2 inhibitors may increase cardiovascular risk are selective inhibition of prostaglandin I2 over thromboxane A2 within the eicosanoid pathway, which promotes thrombosis, and inhibition of prostaglandins E2 and I2 within the kidney, which leads to sodium and water retention and blood pressure elevation.
Spec (may) Positive_regulation (increase) of Negative_regulation (inhibitors) of cyclooxygenase-2 in blood associated with pressure and volume under development and thrombosis
2) Confidence 0.47 Published 2004 Journal Expert Rev Cardiovasc Ther Section Abstract Doc Link 15151474 Disease Relevance 0.41 Pain Relevance 0.16
Selective inhibition of PGHS-2 over myeloperoxidase and horseradish peroxidase isozyme C was increased by certain ring substitutions.
Positive_regulation (increased) of Negative_regulation (inhibition) of PGHS-2
3) Confidence 0.42 Published 2004 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 15464732 Disease Relevance 0.05 Pain Relevance 0.10
All the results indicate that mutations of His513 and Ile523 residues of PGHS-1 can strongly increase sensitivity to selective PGHS-2 inhibition and restore time-dependent inhibition.
Positive_regulation (increase) of Negative_regulation (inhibition) of PGHS-2
4) Confidence 0.40 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9083063 Disease Relevance 0 Pain Relevance 0.17
Each drug produced a concentration-dependent activation of the PPAR isoforms and fatty acid beta-oxidase activity, inhibition of human arachidonic acid-induced platelet aggregation and serotonin secretion, and inhibition of PGHS-1 and PGHS-2 activities.
Positive_regulation (produced) of Negative_regulation (inhibition) of PGHS-2 in platelet associated with serotonin
5) Confidence 0.31 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11755111 Disease Relevance 0.08 Pain Relevance 0.20
Aromatic hydrazides are metabolically activated inhibitors of peroxidases. 2-Naphthoichydrazide (2-NZH) caused the time- and concentration-dependent inhibition of both PGHS-2 peroxidase and cyclooxygenase activities.
Positive_regulation (caused) of Negative_regulation (inhibition) of PGHS-2 peroxidase
6) Confidence 0.28 Published 2004 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 15464732 Disease Relevance 0.07 Pain Relevance 0.11
BACKGROUND: Selective inhibitors of cyclooxygenase 2 (COX-2) are generally tolerated by patients sensitive to nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit COX-1.
Positive_regulation (tolerated) of Negative_regulation (inhibitors) of cyclooxygenase 2 associated with inflammation, cinod and cox2
7) Confidence 0.14 Published 2005 Journal Ann. Allergy Asthma Immunol. Section Abstract Doc Link 15702813 Disease Relevance 0.17 Pain Relevance 0.57
Recent evidence suggests that both cyclooxygenase-2 (COX-2) inhibitors and nonselective NSAIDs, with the possible exception of naproxen, increase cardiovascular (CV) hazard.
Positive_regulation (increase) of Negative_regulation (inhibitors) of cyclooxygenase-2 associated with cinod
8) Confidence 0.03 Published 2008 Journal Am. J. Gastroenterol. Section Abstract Doc Link 17900323 Disease Relevance 0.14 Pain Relevance 0.32
Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain.
Positive_regulation (increases) of Negative_regulation (Inhibition) of cyclooxygenase-2 associated with endocannabinoid, ipn, cox2 and analgesia
9) Confidence 0.03 Published 2008 Journal Neuropharmacology Section Title Doc Link 18534634 Disease Relevance 0.63 Pain Relevance 1.05

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