INT6851

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Context Info
Confidence 0.35
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.84
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 2
endothelial cells 2
epithelial cells 2
polymorphonuclear leukocytes 2
fibroblasts 1
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 32 100.00 Very High Very High Very High
b2 receptor 45 99.80 Very High Very High Very High
Inflammation 115 97.68 Very High Very High Very High
Pain 96 93.64 High High
bradykinin 153 91.60 High High
B1 receptor 51 68.12 Quite High
nociceptor 12 63.76 Quite High
Eae 42 58.52 Quite High
Inflammatory mediators 9 55.28 Quite High
Kinase C 9 52.80 Quite High
Disease Link Frequency Relevance Heat
Corneal Neovascularization 22 99.12 Very High Very High Very High
INFLAMMATION 112 97.68 Very High Very High Very High
Injury 110 96.44 Very High Very High Very High
Pain 102 93.64 High High
Pressure And Volume Under Development 6 91.44 High High
Rheumatoid Arthritis 24 88.64 High High
Synovitis 6 75.44 Quite High
Disease 19 75.00 Quite High
Nociception 6 74.00 Quite High
Inflammatory Pain 39 58.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, cellular localization of B1 and B2 receptor in the present study could be gingival fibroblasts, epithelial cells in oral mucosa or the inflammatory cellular infiltrate.
Localization (localization) of B1 in epithelial cells associated with inflammation and b2 receptor
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 0.65
Immunohistochemical studies showed immunoreactivity for both B1 and B2 receptors in epithelial cells, submucosal glands, fibroblast, vascular smooth muscle, vascular endothelial cells, and macrophages of human nasal turbinates [36].
Localization (receptors) of B1 in epithelial cells
2) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.79 Pain Relevance 0.76
The activated B1 and B2 receptors might cause release of other powerful non-cytokines and cytokines mediators of inflammation, for example, PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Localization (release) of B1 in endothelial cells associated with inflammation and cytokine
3) Confidence 0.24 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.04 Pain Relevance 0.44
The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Localization (release) of B1 in endothelial cells associated with inflammation and cytokine
4) Confidence 0.23 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.88 Pain Relevance 0.41
Thus, cellular localization of B1 and B2 receptor in the present study could be gingival fibroblasts, epithelial cells in oral mucosa or the inflammatory cellular infiltrate.
Localization (localization) of B1 in fibroblasts associated with inflammation and b2 receptor
5) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 0.65
The activated B1 and B2 receptors might cause release of other powerful non-cytokines and cytokines mediators of inflammation, for example, PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Localization (release) of B1 in polymorphonuclear leukocytes associated with inflammation and cytokine
6) Confidence 0.08 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.04 Pain Relevance 0.44
The activated B1 and B2 receptors might cause release of other powerful non-cytokines and cytokines mediators of inflammation, for example, PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Localization (release) of B1 in macrophages associated with inflammation and cytokine
7) Confidence 0.08 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.04 Pain Relevance 0.44
The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Localization (release) of B1 in polymorphonuclear leukocytes associated with inflammation and cytokine
8) Confidence 0.08 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.88 Pain Relevance 0.41
The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Localization (release) of B1 in macrophages associated with inflammation and cytokine
9) Confidence 0.08 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.88 Pain Relevance 0.41
Similar results were observed with B1 at 25 ?
Localization (observed) of B1
10) Confidence 0.05 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0 Pain Relevance 0
Moreover, our findings may be due to the presence of other cytokines (transforming growth factor a and b2; TGF a and b1, and FGF involved in corneal neovascularization in addition to VEGF) [21].
Localization (presence) of b1 associated with corneal neovascularization and cytokine
11) Confidence 0.02 Published 2010 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2916105 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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