INT68514

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.56
Pain Relevance 9.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
spinal 4
nerve 1
nervous system 1
ovary 1
hippocampus 1
Pnoc (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 72 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
opioid receptor 17 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
Pain 13 98.28 Very High Very High Very High
Neuropathic pain 7 97.60 Very High Very High Very High
Thermal hyperalgesia 4 97.56 Very High Very High Very High
Hippocampus 4 97.20 Very High Very High Very High
Sciatic nerve 5 93.76 High High
dorsal root ganglion 11 93.72 High High
Disease Link Frequency Relevance Heat
Pain 6 98.28 Very High Very High Very High
Nociception 11 98.00 Very High Very High Very High
Neuropathic Pain 9 97.60 Very High Very High Very High
Injury 4 97.32 Very High Very High Very High
Ganglion Cysts 14 93.72 High High
Hyperalgesia 4 91.44 High High
Bordatella Infection 3 85.52 High High
Nervous System Injury 3 78.88 Quite High
INFLAMMATION 2 77.52 Quite High
Inflammatory Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that spinal ORL1 receptor activation by nociceptin inhibits the spinal facilitation evoked by the nerve constriction injury.
nociceptin Positive_regulation (activation) of ORL1 receptor in nerve associated with orphanin and injury
1) Confidence 0.59 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9086468 Disease Relevance 0.60 Pain Relevance 0.90
Despite this, the spinal administration of nociceptin or agonists that activate ORL1 (opioid-like orphan receptor) may prove to be of clinical interest in the management of neuropathic pain.
nociceptin Positive_regulation (activate) of ORL1 in spinal associated with orphanin, neuropathic pain, agonist and opioid
2) Confidence 0.43 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822729 Disease Relevance 0.42 Pain Relevance 1.43
Despite this, the spinal administration of nociceptin or agonists that activate ORL1 (opioid-like orphan receptor) may prove to be of clinical interest in the management of neuropathic pain.
nociceptin Positive_regulation (activate) of opioid-like orphan receptor in spinal associated with orphanin, neuropathic pain, agonist and opioid
3) Confidence 0.43 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822729 Disease Relevance 0.42 Pain Relevance 1.43
The recently discovered endogenous peptide orphanin FQ/nociceptin (OFQ/N) activates the opioid receptor-like 1 (ORL1) receptor and produces diverse effects on pain perception.
orphanin FQ Positive_regulation (activates) of ORL1 associated with pain, orphanin and opioid receptor
4) Confidence 0.39 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.10 Pain Relevance 0.97
The present study is the first to investigate systematically whether activation of opioid receptor-like 1 receptor (ORL1) by orphanin FQ (OFQ) produces sex-specific modulation of spinal nociception and whether estrogen or testosterone contributes to these differences using the rat as an experimental animal.
orphanin FQ Spec (whether) Positive_regulation (activation) of opioid receptor-like 1 receptor in spinal associated with nociception, orphanin and opioid receptor
5) Confidence 0.32 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17167094 Disease Relevance 0.35 Pain Relevance 0.63
The present study is the first to investigate systematically whether activation of opioid receptor-like 1 receptor (ORL1) by orphanin FQ (OFQ) produces sex-specific modulation of spinal nociception and whether estrogen or testosterone contributes to these differences using the rat as an experimental animal.
orphanin FQ Spec (whether) Positive_regulation (activation) of ORL1 in spinal associated with nociception, orphanin and opioid receptor
6) Confidence 0.32 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17167094 Disease Relevance 0.35 Pain Relevance 0.63
The present study was designed to investigate whether activation of the ORL1 receptor by its natural ligand, orphanin FQ, could modulate synaptic transmission and synaptic plasticity in the hippocampus.
orphanin FQ Positive_regulation (activation) of ORL1 receptor in hippocampus associated with orphanin and hippocampus
7) Confidence 0.29 Published 1997 Journal Hippocampus Section Abstract Doc Link 9138672 Disease Relevance 0 Pain Relevance 0.63
Nociceptin (NC), by activating its receptor, the opioid receptor-like 1 (ORL1) receptor, exerts an effect on a number of functions in the nervous system including locomotion, learning and memory, and processing of pain signals.
Nociceptin Positive_regulation (activating) of ORL1 in nervous system associated with pain, orphanin and opioid receptor
8) Confidence 0.28 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.02 Pain Relevance 0.95
Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids.
nociceptin Positive_regulation (activation) of ORL 1 receptor associated with orphanin, opioid receptor and opioid
9) Confidence 0.08 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9083791 Disease Relevance 0 Pain Relevance 0.97
Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids.
nociceptin Positive_regulation (activation) of ORL 1 receptor associated with orphanin, opioid receptor and opioid
10) Confidence 0.03 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9083791 Disease Relevance 0 Pain Relevance 0.98
Nociceptin stimulation of the ORL1 receptor expressed in Chinese hamster ovary (CHO) cells results in the activation of the extracellular signal regulated kinases ERK1 and ERK2.
Nociceptin Positive_regulation (stimulation) of ORL1 in ovary associated with orphanin
11) Confidence 0.01 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760105 Disease Relevance 0.28 Pain Relevance 0.05

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