INT68519

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.55
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
enteroendocrine cells 1
dorsal root ganglia 1
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 99.84 Very High Very High Very High
Serotonin 5 99.32 Very High Very High Very High
IPN 28 97.52 Very High Very High Very High
fluoxetine 8 91.88 High High
opioid receptor 2 91.64 High High
tissue acidosis 2 91.48 High High
depression 6 88.36 High High
Opioid 2 81.32 Quite High
Inflammation 50 78.32 Quite High
Delta opioid receptors 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 16 99.84 Very High Very High Very High
Stress 25 99.20 Very High Very High Very High
Inflammatory Pain 28 97.52 Very High Very High Very High
Nociception 9 96.16 Very High Very High Very High
Sprains And Strains 4 92.76 High High
Acidosis 2 91.48 High High
Anxiety Disorder 2 91.36 High High
Depression 6 88.36 High High
INFLAMMATION 51 78.32 Quite High
Hyperglycemia 8 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lysates were cleared by ultracentrifugation and Cugbp1-bound fragments were immunoprecipitated using mAb 3B1 and Protein G Dynabeads (Invitrogen, Carlsbad, CA).
Gene_expression (using) of Protein G
1) Confidence 0.65 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0 Pain Relevance 0.03
Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q.
Gene_expression (expression) of G-protein associated with stress and serotonin
2) Confidence 0.17 Published 2007 Journal J. Neurosci. Section Title Doc Link 17287521 Disease Relevance 1.21 Pain Relevance 0.42
Enriched and nonenriched BALB/c mice exposed to early life stress also exhibited significantly increased expression of mRNA and protein encoding the G alpha q subunit of G-protein that couples to 5-HT2A/2C receptors.
Gene_expression (expression) of G-protein associated with stress
3) Confidence 0.15 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17287521 Disease Relevance 1.05 Pain Relevance 0.49
The distinct G-protein expression in insect cells may be considered an advantage for studying functions of G protein-coupled receptors.
Gene_expression (expression) of G-protein
4) Confidence 0.04 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084406 Disease Relevance 0 Pain Relevance 0.41
In favor of a role of intestinal glucose sensing, it has recently been shown that the sweet-taste receptor subunit T1R3 and the taste G-protein gustducin are expressed in enteroendocrine cells and underlie intestinal sugar sensing and regulation of SGLT1 mRNA and protein (29).
Gene_expression (expressed) of G-protein in enteroendocrine cells
5) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.08 Pain Relevance 0
We previously found that all four proton-sensing G-protein-coupled receptors (GPCRs) are expressed in pain-relevant loci (dorsal root ganglia, DRG), which suggests their possible involvement in nociception, but their functions in pain remain unclear.


Gene_expression (expressed) of G-protein in dorsal root ganglia associated with nociception and pain
6) Confidence 0.02 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2716309 Disease Relevance 1.22 Pain Relevance 0.90

General Comments

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