INT6852

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Context Info
Confidence 0.81
First Reported 1988
Last Reported 2011
Negated 18
Speculated 17
Reported most in Abstract
Documents 883
Total Number 900
Disease Relevance 705.95
Pain Relevance 270.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 81
monocytes 31
mononuclear cells 17
microglia 17
T cells 16
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14037 100.00 Very High Very High Very High
cytokine 9718 100.00 Very High Very High Very High
rheumatoid arthritis 7088 100.00 Very High Very High Very High
chemokine 1625 100.00 Very High Very High Very High
Etanercept 1553 100.00 Very High Very High Very High
cINOD 845 100.00 Very High Very High Very High
metalloproteinase 842 100.00 Very High Very High Very High
Inflammatory mediators 693 100.00 Very High Very High Very High
fibrosis 555 100.00 Very High Very High Very High
substance P 374 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 15727 100.00 Very High Very High Very High
Disease 8095 100.00 Very High Very High Very High
Rheumatoid Arthritis 7286 100.00 Very High Very High Very High
Cancer 4601 100.00 Very High Very High Very High
Obesity 4296 100.00 Very High Very High Very High
Necrosis 1634 100.00 Very High Very High Very High
Pressure And Volume Under Development 968 100.00 Very High Very High Very High
Endometriosis 617 100.00 Very High Very High Very High
Fibrosis 567 100.00 Very High Very High Very High
Cirrhosis 565 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that minimal mechanical trauma is sufficient to induce significant TNF-alpha release in the skin.
Localization (release) of TNF-alpha in skin associated with injury
1) Confidence 0.81 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19931249 Disease Relevance 0.10 Pain Relevance 0.37
Mechanical but not painful electrical stimuli trigger TNF alpha release in human skin.
Localization (release) of TNF in skin associated with pain
2) Confidence 0.81 Published 2010 Journal Exp. Neurol. Section Title Doc Link 19931249 Disease Relevance 0.48 Pain Relevance 0.90
The stimuli inducing TNF-alpha release in humans and the time course of this release are largely unknown.
Localization (release) of TNF-alpha
3) Confidence 0.81 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19931249 Disease Relevance 0.48 Pain Relevance 0.50
Based on our previous evidence that tumour necrosis factor-alpha (TNF-alpha) acts as an endogenous tumour promoter on BALB/3T3 cells initiated with 3-methylcholanthrene, we found that morphine dose-dependently inhibited TnF-alpha release from KATO III cells (IC50, 5.6 mM) and also from BALB/3T3 cells (IC50, 1.3 mM) induced by okadaic acid, one of the non-TPA type tumour promoters.
Localization (release) of TnF-alpha in KATO III associated with necrosis, cancer and morphine
4) Confidence 0.81 Published 1996 Journal Carcinogenesis Section Abstract Doc Link 8968046 Disease Relevance 1.14 Pain Relevance 0.83
Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression.
Localization (release) of tumour necrosis factor-alpha associated with necrosis, cancer and morphine
5) Confidence 0.81 Published 1996 Journal Carcinogenesis Section Title Doc Link 8968046 Disease Relevance 1.12 Pain Relevance 0.79
A bell-shaped dose-response curve was observed for the priming effect of morphine; maximal enhancement of TNF-alpha release (310 +/- 15% of control) was detected at a concentration of 10(-10) M morphine.
Localization (release) of TNF-alpha associated with morphine
6) Confidence 0.81 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.39 Pain Relevance 0.99
Microglial cell cultures did not release TNF-alpha when incubated with morphine alone; however, an enhanced (P < .01) release of TNF-alpha was observed when cultures were first primed with morphine for 24 h and then stimulated with lipopolysaccharide.
Neg (not) Localization (release) of TNF-alpha in Microglial cell associated with morphine
7) Confidence 0.81 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.42 Pain Relevance 0.85
Microglial cell cultures did not release TNF-alpha when incubated with morphine alone; however, an enhanced (P < .01) release of TNF-alpha was observed when cultures were first primed with morphine for 24 h and then stimulated with lipopolysaccharide.
Localization (release) of TNF-alpha in Microglial cell associated with morphine
8) Confidence 0.81 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.41 Pain Relevance 0.88
In the present study, we investigated the effect of morphine on the release of tumor necrosis factor (TNF)-alpha from murine neonatal microglia.
Localization (release) of TNF in microglia associated with necrosis, cancer and morphine
9) Confidence 0.81 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.42 Pain Relevance 0.70
Taken together, these findings indicate that morphine suppresses the release of bioactive TNF from PBMC and that TGF-beta plays a modulatory role in this inhibitory process.
Localization (release) of TNF in PBMC associated with morphine
10) Confidence 0.80 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8389331 Disease Relevance 0.15 Pain Relevance 0.89
The mechanism of morphine-induced suppression of TNF release appears to be counteracted by the effect of this opiate on the release of transforming growth factor (TGF)-beta, since antibodies to this immunoregulatory cytokine further enhanced morphine-related inhibition of TNF release.
Localization (release) of TNF associated with opiate, cytokine and morphine
11) Confidence 0.80 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8389331 Disease Relevance 0.15 Pain Relevance 0.95
Pretreatment of PBMC cultures for 1 h with naloxone blocked (P < 0.05) the inhibitory effect of morphine on the release of TNF upon stimulation with phytohemagglutinin, but not with lipopolysaccharide, suggesting the involvement of an opioid receptor.
Localization (release) of TNF in PBMC associated with narcan, opioid receptor and morphine
12) Confidence 0.80 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8389331 Disease Relevance 0.15 Pain Relevance 0.91
Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell cultures.
Localization (release) of tumor necrosis factor in blood associated with necrosis, cancer and morphine
13) Confidence 0.80 Published 1993 Journal Int. J. Immunopharmacol. Section Title Doc Link 8389331 Disease Relevance 0.20 Pain Relevance 0.91
When PBMC were treated with morphine for 24 h, cells released less (P < 0.05) bioactive TNF, a cytokine important in host defense, in the following 24-h incubation period when stimulated with lipopolysaccharide and phytohemagglutinin.
Localization (released) of TNF in PBMC associated with cytokine and morphine
14) Confidence 0.80 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8389331 Disease Relevance 0.15 Pain Relevance 0.67
The reduction of tumor necrosis factor-alpha (TNF-alpha) release from LPS-stimulated human monocytic cell line (THP-1) was also demonstrated in cells that were pre-incubated with the extract.
Localization (release) of tumor necrosis factor-alpha in THP-1 associated with necrosis and cancer
15) Confidence 0.80 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16831527 Disease Relevance 1.15 Pain Relevance 0.38
The reduction of tumor necrosis factor-alpha (TNF-alpha) release from LPS-stimulated human monocytic cell line (THP-1) was also demonstrated in cells that were pre-incubated with the extract.
Localization (release) of TNF-alpha in THP-1 associated with necrosis and cancer
16) Confidence 0.80 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16831527 Disease Relevance 1.14 Pain Relevance 0.37
It has, however, recently been shown that human macrophages cultured with acetaminophen secrete increased quantities of tumour necrosis factor (TNF).
Localization (secrete) of TNF in macrophages associated with necrosis, paracetamol and cancer
17) Confidence 0.80 Published 1996 Journal J. Pathol. Section Abstract Doc Link 8869293 Disease Relevance 0.61 Pain Relevance 0.67
Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages.
Localization (release) of tumor necrosis factor-alpha in macrophages associated with necrosis and cancer
18) Confidence 0.80 Published 2007 Journal J Endod Section Abstract Doc Link 17509409 Disease Relevance 0.38 Pain Relevance 0.25
Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages.
Localization (release) of TNF-alpha in macrophages associated with necrosis and cancer
19) Confidence 0.80 Published 2007 Journal J Endod Section Abstract Doc Link 17509409 Disease Relevance 0.38 Pain Relevance 0.25
In atrial tissue obtained from seven patients TNF-alpha released into the culture medium at 360 minutes was 6 +/- 3 pg/mg tissue.
Localization (released) of TNF-alpha
20) Confidence 0.80 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.20 Pain Relevance 0.11

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