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Context Info
Confidence 0.06
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.41

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plasma membrane (ADCY1, OPRD1) small molecule metabolic process (ADCY1) GTPase activity (ADCY1)
cytoplasm (OPRD1) signal transducer activity (OPRD1) transmembrane transport (ADCY1)
ADCY1 (Homo sapiens)
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 100.00 Very High Very High Very High
opioid receptor 4 97.72 Very High Very High Very High
Immobilon 3 86.84 High High
Delta opioid receptors 1 51.80 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that the delta-opioid receptor-mediated inhibitory response of adenylyl cyclase undergoes heterolgous desensitization, and it is suggested that delta-opioid and D2-dopaminergic receptors are coupled to adenylyl cyclase via a G12 protein, whereas alpha 2-adrenergic receptor could be coupled to the enzyme via two G proteins, G12 and another member of the G1/G0 family.
adenylyl cyclase Binding (coupled) of delta-opioid associated with opioid receptor and opioid
1) Confidence 0.06 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084451 Disease Relevance 0.07 Pain Relevance 0.41

General Comments

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