INT6853

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 30
Disease Relevance 14.05
Pain Relevance 16.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 3
synovial fluid 2
macrophages 2
neuronal 2
sensory nerve 2
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
b2 receptor 477 100.00 Very High Very High Very High
B1 receptor 177 100.00 Very High Very High Very High
Nicotine 1344 99.98 Very High Very High Very High
dexamethasone 154 99.60 Very High Very High Very High
Inflammation 479 99.52 Very High Very High Very High
cytokine 83 99.44 Very High Very High Very High
Pain 137 99.40 Very High Very High Very High
Inflammatory response 2 99.20 Very High Very High Very High
bradykinin 810 99.16 Very High Very High Very High
antagonist 131 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 15 99.58 Very High Very High Very High
INFLAMMATION 478 99.52 Very High Very High Very High
Pain 143 99.40 Very High Very High Very High
Pressure And Volume Under Development 36 99.28 Very High Very High Very High
Increased Venous Pressure Under Development 14 98.76 Very High Very High Very High
Injury 159 96.84 Very High Very High Very High
Rheumatoid Arthritis 32 95.76 Very High Very High Very High
Inflammatory Pain 52 94.08 High High
Nicotine Addiction 168 91.88 High High
Asthma 210 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we examined the vascular inflammatory responses and nociceptive effects resulting from activation of B1 and B2 receptors in healthy and UV-B irradiated skin in human volunteers.
Positive_regulation (activation) of B1 in skin associated with nociception and inflammatory response
1) Confidence 0.40 Published 2004 Journal Pain Section Abstract Doc Link 15275768 Disease Relevance 0.37 Pain Relevance 0.70
The activated B1 and B2 receptors might cause release of other powerful non-cytokines and cytokines mediators of inflammation, for example, PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Positive_regulation (activated) of B1 in endothelial cells associated with inflammation and cytokine
2) Confidence 0.34 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.03 Pain Relevance 0.43
Excessive release of kinins in the synovial fluid can produce oedema, pain and loss of functions due to activation of B1 and B2 receptors.
Positive_regulation (activation) of B1 in synovial fluid associated with pain and pressure and volume under development
3) Confidence 0.34 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 0.85 Pain Relevance 0.33
Excessive release of kinin (BK) in the synovial fluid can produce oedema, pain and loss of functions due to activation of B1 and B2 kinin receptors.
Positive_regulation (activation) of B1 in synovial fluid associated with pain and pressure and volume under development
4) Confidence 0.32 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.72 Pain Relevance 0.32
The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Positive_regulation (activated) of B1 in endothelial cells associated with inflammation and cytokine
5) Confidence 0.32 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.87 Pain Relevance 0.40
On the other hand, B1 receptors are induced during the inflammatory processes or at least strongly regulated, except in the spinal cord, where they are constitutively expressed in both rat and man [9].
Positive_regulation (induced) of B1 in spinal cord associated with inflammation and spinal cord
6) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 1.02
Therefore, it is possible that kinins besides activating B1 and B2 receptors on sensory nerve terminals, also activate B1 and B2 receptors on gingival fibroblasts or inflammatory cells inducing the expression of these cytokines, which contributes to the development of inflammatory pain.
Positive_regulation (activating) of B1 in sensory nerve associated with inflammation, eae and cytokine
7) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.40 Pain Relevance 0.62
Several other studies showed an induction of IL-6, IL-8 and CCL2 via activation of B1 or B2 receptors in a variety of cells [41-47].
Positive_regulation (activation) of B1
8) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.39 Pain Relevance 0.62
Therefore, it is possible that kinins besides activating B1 and B2 receptors on sensory nerve terminals, also activate B1 and B2 receptors on gingival fibroblasts or inflammatory cells inducing the expression of these cytokines, which contributes to the development of inflammatory pain.
Positive_regulation (activate) of B1 in sensory nerve associated with inflammation, eae and cytokine
9) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.40 Pain Relevance 0.59
In normal skin, both B1 and B2 receptor activation dose-dependently evoked pain, vasodilatation and protein extravasation.
Positive_regulation (activation) of B1 in skin associated with pain, b2 receptor and increased venous pressure under development
10) Confidence 0.19 Published 2004 Journal Pain Section Abstract Doc Link 15275768 Disease Relevance 0.75 Pain Relevance 1.02
The activated B1 and B2 receptors might cause release of other powerful non-cytokines and cytokines mediators of inflammation, for example, PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Positive_regulation (activated) of B1 in macrophages associated with inflammation and cytokine
11) Confidence 0.12 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.03 Pain Relevance 0.43
The activated B1 and B2 receptors might cause release of other powerful non-cytokines and cytokines mediators of inflammation, for example, PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Positive_regulation (activated) of B1 in polymorphonuclear leukocytes associated with inflammation and cytokine
12) Confidence 0.12 Published 1992 Journal Agents Actions Suppl. Section Abstract Doc Link 1334358 Disease Relevance 1.03 Pain Relevance 0.43
The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Positive_regulation (activated) of B1 in macrophages associated with inflammation and cytokine
13) Confidence 0.11 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.87 Pain Relevance 0.40
The activated B1 and B2 receptors might cause release of other powerful non-cytokine and cytokine mediators of inflammation, e.g., PGE2, PGI2, LTs, histamine, PAF, IL-1 and TNF, derived mainly from polymorphonuclear leukocytes, macrophages, endothelial cells and synovial tissue.
Positive_regulation (activated) of B1 in polymorphonuclear leukocytes associated with inflammation and cytokine
14) Confidence 0.11 Published 1994 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 7703672 Disease Relevance 0.87 Pain Relevance 0.40
These findings are consistent with other evidence that peptide B1 receptor antagonists inhibit spinal nociceptive reflexes only after induction of B1 receptors by inflammation and support the potential therapeutic utility of B1 receptor antagonists as analgesic and anti-inflammatory drugs.
Positive_regulation (induction) of B1 in spinal associated with nociception, inflammation, analgesic, antagonist, b1 receptor and cinod
15) Confidence 0.07 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025959 Disease Relevance 0.82 Pain Relevance 0.78
An increase in kinin B1 (Fig. 5A-B) and B2 (Fig. 5C-D) receptor protein expressions were seen in both the airway epithelial and smooth muscle cells (Fig. 5E-F).
Positive_regulation (increase) of B1 in smooth muscle cells
16) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.40
Stimulation of kinin B1 and B2 receptors on the airway smooth muscle directly activates the inositol 1,4,5-trisphosphate (IP3) pathway increasing intracellular Ca2+ levels which subsequently activates the cellular contractile machinery [18].
Positive_regulation (Stimulation) of B1 in smooth muscle
17) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.38 Pain Relevance 0.49
The increase in B1 and B2 receptor mRNA and protein expression after organ culture with nicotine strengthens the evidence for an alteration at the receptor level rather than a down-stream process.
Positive_regulation (increase) of B1 associated with nicotine and b2 receptor
18) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.18 Pain Relevance 0.43
In addition, real-time PCR reveals a parallel increase in B1 and B2 receptor mRNA suggesting the involvement of transcriptional mechanisms in nicotine's effects.
Positive_regulation (increase) of B1 associated with nicotine and b2 receptor
19) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.28 Pain Relevance 0.50
In line with this, the present data demonstrates that dexamethasone inhibited nicotine-enhanced kinin B1 and B2 receptor-mediated effects in murine airways.
Positive_regulation (enhanced) of B1 associated with nicotine, b2 receptor and dexamethasone
20) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.25 Pain Relevance 0.52

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