INT6855

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 71
Total Number 74
Disease Relevance 15.64
Pain Relevance 28.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
brain 4
A11 2
blood 2
Capan-1 1
adrenal cortex 1
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 356 100.00 Very High Very High Very High
Opioid 295 100.00 Very High Very High Very High
chemokine 220 100.00 Very High Very High Very High
adenocard 167 100.00 Very High Very High Very High
opioid receptor 134 100.00 Very High Very High Very High
cytokine 95 100.00 Very High Very High Very High
Glutamate receptor 57 100.00 Very High Very High Very High
Dopamine 34 100.00 Very High Very High Very High
Dynorphin 18 100.00 Very High Very High Very High
Kappa opioid receptor 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 475 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 82 99.70 Very High Very High Very High
Overdose 11 98.72 Very High Very High Very High
Post-operative Nausea 15 98.40 Very High Very High Very High
Cocaine Dependence 2 97.96 Very High Very High Very High
Neuroblastoma 5 97.76 Very High Very High Very High
Schizophrenia 10 97.56 Very High Very High Very High
Malignant Neoplastic Disease 28 97.20 Very High Very High Very High
Partial Seizures 1 96.84 Very High Very High Very High
Psychosis 4 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a relatively non-specific ligand that is used as a screen because it interacts with mu, sigma, and delta receptors - as the HPLC detector to detect a range of peptides that derive from proenkephalin A and POMC.
receptors Binding (interacts) of associated with opioid receptor
1) Confidence 0.41 Published 1985 Journal Life Sci. Section Abstract Doc Link 2997570 Disease Relevance 0.17 Pain Relevance 0.21
Conformational and topographical constraint of the linear natural endogenous opioid peptides has played a major role in developing peptide ligands with high selectivity for mu, delta, and kappa receptors, and in understanding the conformational, topographical, and stereoelectronic structural requirements of the opioid peptides for their interactions with opioid receptors.
receptors Binding (interactions) of associated with endogenous opioid, opioid receptor and opioid
2) Confidence 0.31 Published 1999 Journal Biopolymers Section Abstract Doc Link 10797229 Disease Relevance 0.26 Pain Relevance 1.35
Sigma (sigma) receptors, first defined as a subclass of opioid receptors, later confounded with the high affinity phencyclidine (PCP) binding sites, now are regarded as unique binding sites, distinct from opiate and PCP receptors, and related to higher brain function.
receptors Binding (binding) of in brain associated with opiate and opioid receptor
3) Confidence 0.26 Published 2004 Journal Pharmacopsychiatry Section Abstract Doc Link 15547784 Disease Relevance 0.07 Pain Relevance 0.22
We used [18F]cyclofoxy (CF), a potent opiate antagonist with affinity for mu and kappa receptors, and the Scanditronix PC1024-7B PET scanner to study 14 patients with complex partial seizures (CPS), and 14 normal controls.
receptors Binding (affinity) of associated with antagonist, opiate and partial seizures
4) Confidence 0.25 Published 1992 Journal Epilepsy Res. Section Abstract Doc Link 1334456 Disease Relevance 0.26 Pain Relevance 0.26
The liberated corepressor protein SMRT interacts with the signal
SMRT Binding (interacts) of
5) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.23 Pain Relevance 0
Among these two corepressors, only SMRT/TRAC2 was found to be significantly expressed.
SMRT Binding (found) of
6) Confidence 0.12 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
Explant culture of term placental villus trophoblast was investigated for its possible use as a model system for study of the effects of chronic methadone administration on binding and functional properties of placental kappa receptors.
receptors Binding (binding) of in villus associated with methadone
7) Confidence 0.07 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791132 Disease Relevance 0 Pain Relevance 0.64
Midazolam, chlordiazepoxide, and diazepam directly displaced [(3)H]-diprenorphine binding from kappa and delta receptors, but not mu receptors, whereas flumazenil was inactive.
receptors Binding (binding) of associated with versed
8) Confidence 0.06 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11473860 Disease Relevance 0 Pain Relevance 0.45
The results suggest that the analgesic efficacy reported for intrathecal benzodiazepines may be attributed, in part, to direct interaction with kappa-opioid receptors.
receptors Binding (interaction) of associated with analgesic, kappa opioid receptor and intrathecal
9) Confidence 0.06 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11473860 Disease Relevance 0 Pain Relevance 0.89
Midazolam, chlordiazepoxide, and diazepam directly displaced [(3)H]-diprenorphine binding from kappa and delta receptors, but not mu receptors, whereas flumazenil was inactive.
receptors Binding (binding) of associated with versed
10) Confidence 0.06 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11473860 Disease Relevance 0 Pain Relevance 0.45
We have used in vitro autoradiography and ligand binding to map D3 DA and kappa opioid receptors in the human brains of cocaine-overdose victims.
receptors Binding (binding) of in brains associated with dopamine, kappa opioid receptor, overdose and cocaine
11) Confidence 0.06 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415668 Disease Relevance 0.43 Pain Relevance 1.00
LVV-hemorphin-7 is a peptide with opioid-like activity which is recognized by mu and sigma receptors.
receptors Binding (recognized) of associated with opioid
12) Confidence 0.06 Published 1997 Journal J Chromatogr A Section Abstract Doc Link 9297836 Disease Relevance 0 Pain Relevance 0.14
Our results show that large concentrations of midazolam, chlordiazepoxide, and diazepam displace the binding of [(3)H]-diprenorphine-an opiate radioligand from kappa receptors.
receptors Binding (binding) of associated with versed and opiate
13) Confidence 0.05 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11473860 Disease Relevance 0 Pain Relevance 0.95
We observed similar effects in binding to sigma receptors, inhibition of binding and reversibility of binding in receptors of both human peripheral blood receptors and the mouse neuroblastoma, a hamster brain cell hybrid clone.
receptors Binding (binding) of in blood associated with neuroblastoma
14) Confidence 0.03 Published 1984 Journal Biomed. Pharmacother. Section Abstract Doc Link 6098318 Disease Relevance 0.45 Pain Relevance 0.15
Pentazocine binds only to sigma1 receptors.
receptors Binding (binds) of associated with fortral
15) Confidence 0.03 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.06 Pain Relevance 0.47
Guinea pig brain membranes treated with nanomolar doses of DIGIT followed by extensive washing exhibit a dose dependent reduction of [3H]DTG and (+)[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [+)[3H]3-PPP) binding to sigma receptors.
receptors Binding (binding) of in brain
16) Confidence 0.03 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.14
Treatment of DIGIT-derivatized membranes with 2 M NaCl does not result in recovery of sigma binding activity, suggesting that DIGIT's interaction with sigma receptors is not of an ionic nature.
receptors Binding (interaction) of
17) Confidence 0.03 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.13
Binding of radiolabelled ligands for phencyclidine, mu-opioid, benzodiazepine and dopamine-D2 receptors is not affected by membrane treatment with DIGIT, indicating specificity of the affinity label for sigma-type receptors.
receptors Binding (Binding) of associated with dopamine and opioid
18) Confidence 0.03 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2826177 Disease Relevance 0 Pain Relevance 0.15
We observed similar effects in binding to sigma receptors, inhibition of binding and reversibility of binding in receptors of both human peripheral blood receptors and the mouse neuroblastoma, a hamster brain cell hybrid clone.
receptors Binding (binding) of in blood associated with neuroblastoma
19) Confidence 0.03 Published 1984 Journal Biomed. Pharmacother. Section Abstract Doc Link 6098318 Disease Relevance 0.45 Pain Relevance 0.15
We used mammalian cells transfected with each of the cDNA clones for the human receptors hMOR, hDOR, hKOR and showed that dynorphin A displaced [3H]-diprenorphine binding with Ki values in the nanomolar range at all three receptors.
receptors Binding (binding) of associated with dynorphin
20) Confidence 0.02 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655852 Disease Relevance 0 Pain Relevance 0.99

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