INT68559

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.56
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gli3) intracellular (Gli3) cilium (Gli3)
DNA binding (Gli3) cytoplasm (Gli3) cytosol (Gli3)
Gli3 (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 30 100.00 Very High Very High Very High
Post herpetic neuralgia 22 100.00 Very High Very High Very High
Serotonin 2 99.84 Very High Very High Very High
noradrenaline 2 99.04 Very High Very High Very High
abdominal pain 8 98.78 Very High Very High Very High
Desipramine 2 98.36 Very High Very High Very High
Nortriptyline 2 98.10 Very High Very High Very High
Endep 2 97.80 Very High Very High Very High
sNRI 2 96.24 Very High Very High Very High
Duloxetine 2 93.76 High High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 30 100.00 Very High Very High Very High
Neuralgia 22 100.00 Very High Very High Very High
Abdominal Pain 8 98.78 Very High Very High Very High
Targeted Disruption 59 95.64 Very High Very High Very High
Herpes Simplex Virus Infection 4 92.84 High High
Neuropathic Pain 10 92.12 High High
Pain 14 91.88 High High
Nervous System Injury 2 89.80 High High
Pancreatitis 6 83.12 Quite High
Premature Birth 6 19.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this review is to compare the efficacy and limitations of currently available pharmacological treatments for the symptomatic relief of PHN and PDN, and to discuss the potential of combination therapy in PHN and PDN.
Negative_regulation (relief) of PDN associated with painful diabetic neuropathy and post herpetic neuralgia
1) Confidence 0.37 Published 2008 Journal CNS Drugs Section Abstract Doc Link 18399710 Disease Relevance 1.52 Pain Relevance 1.92
Amitriptyline, nortriptyline, desipramine and imipramine are TCAs that have been shown to be effective for the symptomatic relief of PHN and PDN.
Negative_regulation (relief) of PDN associated with painful diabetic neuropathy, desipramine, nortriptyline, endep and post herpetic neuralgia
2) Confidence 0.37 Published 2008 Journal CNS Drugs Section Abstract Doc Link 18399710 Disease Relevance 1.61 Pain Relevance 1.84
Gli3 levels on d19.0 decrease to 18% of d13.5 in the gravid wild-type mouse, but no differences in Gli3 levels were detected in the Cox-1 KO mouse [24].
Negative_regulation (decrease) of Gli3 associated with targeted disruption
3) Confidence 0.31 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.26 Pain Relevance 0
The incidence of abdominal pain and the elevation in the serum amylase level after ERCP were lower in the UST group than in the control group and abdominal pain and the elevated serum amylase level were almost completely suppressed in the PDN and UST/PDN groups.
Negative_regulation (suppressed) of PDN associated with abdominal pain
4) Confidence 0.11 Published 1997 Journal J. Gastroenterol. Section Abstract Doc Link 9085171 Disease Relevance 0.59 Pain Relevance 0.59
The incidence of abdominal pain and the elevation in the serum amylase level after ERCP were lower in the UST group than in the control group and abdominal pain and the elevated serum amylase level were almost completely suppressed in the PDN and UST/PDN groups.
Negative_regulation (suppressed) of PDN associated with abdominal pain
5) Confidence 0.05 Published 1997 Journal J. Gastroenterol. Section Abstract Doc Link 9085171 Disease Relevance 0.59 Pain Relevance 0.59

General Comments

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