INT6856

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.80
Pain Relevance 7.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cckbr) nucleus (Cckbr) cytoplasm (Cckbr)
signal transducer activity (Cckbr)
Anatomy Link Frequency
neurons 3
dorsal root ganglion 1
ventral 1
Cckbr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 71 100.00 Very High Very High Very High
Root ganglion neuron 9 99.98 Very High Very High Very High
antagonist 8 99.96 Very High Very High Very High
Morphine 7 99.68 Very High Very High Very High
Analgesic 9 99.12 Very High Very High Very High
Central grey 9 98.92 Very High Very High Very High
qutenza 4 98.00 Very High Very High Very High
opiate 7 97.44 Very High Very High Very High
tetrodotoxin 3 97.20 Very High Very High Very High
Spinal cord 15 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 11 99.82 Very High Very High Very High
Urological Neuroanatomy 9 98.92 Very High Very High Very High
Hypersensitivity 1 97.80 Very High Very High Very High
Nervous System Injury 2 89.28 High High
Pain 1 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that CCK-B receptors are expressed by a substantial percentage of dorsal root ganglion neurons at all spinal levels, and that CCK may antagonize opiate analgesia at the level of the primary afferent neuron itself.
Gene_expression (expressed) of CCK-B in dorsal root ganglion associated with ganglion cysts, root ganglion neuron, opiate, cholecystokinin and analgesia
1) Confidence 0.77 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1334505 Disease Relevance 0.24 Pain Relevance 1.41
In the spinal cord, the highest concentration of CCK receptors is found in laminae I and II, which is the major termination site of dorsal root ganglia neurons expressing CCK receptor binding sites.
Gene_expression (expressing) of CCK receptor in neurons associated with cholecystokinin and spinal cord
2) Confidence 0.77 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1334505 Disease Relevance 0.17 Pain Relevance 1.13
Trigeminal and dorsal root ganglion neurons express CCK receptor binding sites in the rat, rabbit, and monkey: possible site of opiate-CCK analgesic interactions.
Gene_expression (express) of CCK receptor in neurons associated with ganglion cysts, analgesic, root ganglion neuron and opiate
3) Confidence 0.77 Published 1992 Journal J. Neurosci. Section Title Doc Link 1334505 Disease Relevance 0.18 Pain Relevance 1.16
In contrast, rat dorsal root ganglions have lower numbers of CCK1 receptor mRNA-positive neurons, and CART is only expressed sparingly in this system.
Gene_expression (expressed) of CCK1 receptor in neurons associated with ganglion cysts
4) Confidence 0.63 Published 2001 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 11713983 Disease Relevance 0.44 Pain Relevance 0.37
We employed dual probe microdialysis in the nucleus accumbens and ipsilateral ventral pallidum of the halothane anaesthetized rat to investigate the effect of intra-accumbens perfusion with the sulphated octapeptide cholecystokinin (CCK-8S, 10-1000 nM, 60 min) alone and in the presence of the selective CCK1 and CCK2 receptor antagonists L-364,718 (10 and 100 nM) and PD134308 (10 nM), tetrodotoxin (TTX, 1000 nM) and the GABA(A) receptor antagonist bicuculline (1000 nM), on dialysate GABA levels in the ventral pallidum.
Gene_expression (presence) of CCK2 in ventral associated with tetrodotoxin, nucleus accumbens, gaba, antagonist, halothane and cholecystokinin
5) Confidence 0.63 Published 2000 Journal Life Sci. Section Abstract Doc Link 11197746 Disease Relevance 0 Pain Relevance 0.58
The results show that CCK-A receptors are significantly more expressed in non-responders than responders, whereas CCK-B receptor expression is similar in both groups.
Gene_expression (expression) of CCK-B receptor associated with cholecystokinin
6) Confidence 0.63 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12023057 Disease Relevance 0 Pain Relevance 0.65
To test for possible compensatory changes the CCK2 receptor due to morphine treatments the expression of CCK2 receptor mRNA was evaluated in the PAG.
Gene_expression (expression) of CCK2 receptor associated with central grey and morphine
7) Confidence 0.59 Published 2007 Journal Peptides Section Abstract Doc Link 17194502 Disease Relevance 0.67 Pain Relevance 1.33
The stimulant effect of CCK-8S was antagonized by the newly synthesized CCK-B selective receptor antagonist PD134308 (10(-7) M and 10(-6) M).
Gene_expression (synthesized) of CCK-B selective receptor associated with antagonist
8) Confidence 0.41 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8587661 Disease Relevance 0 Pain Relevance 0.64
Some animals were pretreated with indomethacin (5 mg/kg, ip), L-NAME (9, 18, 36 and 72 micromol/kg, iv), atropine sulfate (1-2 mg/kg, iv), CCK-1 and CCK-2 receptor antagonists (L-364,718 and L-365,260, 1 mg/kg, iv), exendin (9-39) amide (35 nmol/kg, iv) and lidocaine (74 micromol/kg, iv) prior to the infusion of GLP-2 (4.6 nmol/kg).
Gene_expression (pretreated) of CCK-2 receptor associated with antagonist and lidocaine
9) Confidence 0.31 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17346812 Disease Relevance 0 Pain Relevance 0.29
The CCKBR and ITGbeta2 loci define the ends of the linkage groups on Chromosomes (Chro) (SSC) 9p and 13qter, respectively.
Gene_expression (define) of CCKBR associated with hypersensitivity
10) Confidence 0.25 Published 1997 Journal Mamm. Genome Section Abstract Doc Link 9250860 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox