INT68567

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Context Info
Confidence 0.18
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.82
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Fbxo23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 6 99.66 Very High Very High Very High
gABA 7 96.56 Very High Very High Very High
anesthesia 2 89.04 High High
Dopamine 1 83.84 Quite High
agonist 3 69.60 Quite High
Bioavailability 9 59.04 Quite High
tolerance 3 31.20 Quite Low
midbrain 1 25.00 Low Low
Raphe 1 25.00 Low Low
medulla 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 62 99.08 Very High Very High Very High
Toxicity 5 77.96 Quite High
Overdose 21 71.96 Quite High
Body Weight 1 64.68 Quite High
Impaired Glucose Tolerance 3 31.20 Quite Low
Disease 5 25.00 Low Low
Disorder Of Lipid Metabolism 8 12.80 Low Low
Syndrome 3 9.00 Low Low
Obesity 11 5.00 Very Low Very Low Very Low
Hyperlipidemia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of SSA to GHB strongly supports the proposal that GHB biosynthesis may be an important step in the GABA shunt.
Negative_regulation (Reduction) of GHB associated with gaba
1) Confidence 0.18 Published 1997 Journal Mol. Cells Section Abstract Doc Link 9085259 Disease Relevance 0 Pain Relevance 0.18
Treatment with MCE reduced percent GHb levels from 10.1% (in diabetic control) to 8.0% and 8.1% in rats treated with 300 mg/kg and 150 mg/kg doses respectively.
Negative_regulation (reduced) of GHb associated with diabetes mellitus
2) Confidence 0.08 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2048984 Disease Relevance 0.54 Pain Relevance 0
All flavonoid aglycones that were evaluated inhibited GHB uptake in MCT1-transfected cells, with luteolin, morin, and phloretin resulting in the greatest reduction in GHB uptake (IC50 values of 0.41, 6.21 and 2.57 ?
Negative_regulation (reduction) of GHB
3) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.15 Pain Relevance 0.04
Furthermore, GHB has been demonstrated to be both a substrate and inhibitor for a number of MCT isoforms (10–12,53).
Negative_regulation (inhibitor) of GHB
4) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.06
The high potency of luteolin for inhibiting GHB uptake suggested that this compound may be effective at increasing the renal clearance of GHB.
Negative_regulation (inhibiting) of GHB associated with potency
5) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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