INT68576

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.10
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
plasma 2
CSF 2
brain 2
NK cells 2
neutrophil 2
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 82 100.00 Very High Very High Very High
cytokine 80 100.00 Very High Very High Very High
fibrosis 2 99.92 Very High Very High Very High
cva 20 99.90 Very High Very High Very High
Inflammatory response 21 99.60 Very High Very High Very High
Clonidine 10 99.40 Very High Very High Very High
Inflammation 152 98.40 Very High Very High Very High
Analgesic 2 96.88 Very High Very High Very High
ischemia 7 94.80 High High
dexamethasone 9 87.92 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 93 100.00 Very High Very High Very High
Fibrosis 3 99.92 Very High Very High Very High
Cv General 3 Under Development 20 99.90 Very High Very High Very High
INFLAMMATION 193 99.60 Very High Very High Very High
Bacterial Meningitis 21 99.44 Very High Very High Very High
Pulmonary Eosinophilia 1 99.40 Very High Very High Very High
Asthma 41 99.16 Very High Very High Very High
Neutrophil Disorders 22 98.90 Very High Very High Very High
Cancer 83 98.20 Very High Very High Very High
Neutropenia 3 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that I.V. administration of four times the dose of clonidine delivered spinally failed to induce a significant increase of ACh in the CSF.
Neg (failed) Positive_regulation (induce) of Positive_regulation (increase) of CSF in CSF associated with clonidine
1) Confidence 0.40 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9085961 Disease Relevance 0.06 Pain Relevance 1.12
Levels of IL-6 and G-CSF were elevated during the active phase, but the level of IL-1beta did not increase.
Positive_regulation (elevated) of Positive_regulation (elevated) of G-CSF
2) Confidence 0.32 Published 2003 Journal Int. J. Hematol. Section Abstract Doc Link 12774928 Disease Relevance 1.85 Pain Relevance 0.24
Hong et al. conducted a careful measurement of CSF DJ-1, as described above for CSF ?
Positive_regulation (conducted) of Positive_regulation (measurement) of CSF
3) Confidence 0.29 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000080 Disease Relevance 1.00 Pain Relevance 0
Increased levels of IL-6 and GM-CSF have also been detected in the BAL fluid of asthmatic subjects [10].
Positive_regulation (detected) of Positive_regulation (Increased) of GM-CSF associated with asthma
4) Confidence 0.18 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.42 Pain Relevance 0.49
In theory, SCN and CN are caused by an accumulation of neutrophil elastase, leading to an inactivation of G-CSF and a negative feedback on granulopoiesis, which causes neutropenia.
Positive_regulation (leading) of Positive_regulation (inactivation) of G-CSF in neutrophil associated with neutropenia and neutrophil disorders
5) Confidence 0.11 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.91 Pain Relevance 0
Such a decrease of PAF-AH activity may in part be responsible for the reported increase of PAF in MS plasma and CSF, and therefore could contribute to the inflammation and vascular permeability changes seen in the CNS of MS.
Positive_regulation (responsible) of Positive_regulation (increase) of CSF in plasma associated with multiple sclerosis and inflammation
6) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.05 Pain Relevance 0.52
In the supernatants of untreated NK cells co-cultured with UCLA-OSCCs, synergistic induction of GM-CSF, IL-6 and IL-8 could be observed since much lower levels of these cytokines were induced either in the presence of NK cells alone or tumor cells alone (Table 2).
Positive_regulation (induced) of Positive_regulation (induction) of GM-CSF in NK cells associated with cancer and cytokine
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.47 Pain Relevance 0.14
In our previous studies of experimental neonatal bacterial meningitis (3, 25), increased ICP and elevated CSF lactate level were primarily attributable to acute inflammatory responses in the subarachnoid space rather than to brain edema and cerebral energy depletion from cerebral ischemia, respectively.
Positive_regulation (attributable) of Positive_regulation (elevated) of CSF in brain associated with pressure and volume under development, inflammatory response, bacterial meningitis, cv general 4 under development, ischemia and cva
8) Confidence 0.04 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779288 Disease Relevance 1.34 Pain Relevance 0.33

General Comments

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