INT68581

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 6
Disease Relevance 1.21
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
dorsal 1
DRG 1
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 30 100.00 Very High Very High Very High
opioid receptor 8 100.00 Very High Very High Very High
Inflammation 7 99.74 Very High Very High Very High
Pain 4 97.92 Very High Very High Very High
Spinal cord 5 96.56 Very High Very High Very High
Raphe magnus 5 96.56 Very High Very High Very High
Raphe 1 95.48 Very High Very High Very High
Central grey 1 93.92 High High
Limbic system 3 89.84 High High
electroacupuncture 7 83.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.74 Very High Very High Very High
Pain 2 97.92 Very High Very High Very High
Urological Neuroanatomy 1 93.92 High High
Nociception 2 93.84 High High
Lordosis 3 85.12 High High
Neuropathic Pain 5 80.00 Quite High
Injury 1 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown, using reverse transcription-polymerase chain reaction (RT-PCR), that carrageenan-produced peripheral inflammation induces the expression of prepronociceptin (PPN) mRNA in the dorsal root ganglia (DRG).
Transcription (expression) of prepronociceptin in DRG associated with inflammation
1) Confidence 0.70 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11448514 Disease Relevance 0.41 Pain Relevance 0.47
Previous studies have shown that both OFQ immunoreactivity and preproorphanin FQ (ppOFQ) mRNA expression could be observed in the brain regions involved in pain modulation, e.g., nucleus of raphe magnus (NRM), dorsal raphe nucleus (DRN), and ventrolateral periaqueductal gray (vlPAG).
Transcription (expression) of preproorphanin FQ in dorsal associated with raphe magnus, pain, central grey and raphe
2) Confidence 0.67 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 15249116 Disease Relevance 0.47 Pain Relevance 1.19
High pressure liquid chromatography (HPLC) showed that the immunoreactive material was heterogeneous with the major part eluting at the position of synthetic nociceptin.
Transcription (position) of nociceptin associated with orphanin
3) Confidence 0.60 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9086475 Disease Relevance 0.08 Pain Relevance 0.60
Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.
Transcription (expression) of nociceptin associated with orphanin and opioid receptor
4) Confidence 0.48 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 16538678 Disease Relevance 0.09 Pain Relevance 0.43
Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.
Transcription (expression) of nociceptin associated with orphanin and opioid receptor
5) Confidence 0.21 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 16538678 Disease Relevance 0.09 Pain Relevance 0.43
Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.
Transcription (expression) of orphanin FQ associated with orphanin and opioid receptor
6) Confidence 0.21 Published 2006 Journal J. Comp. Neurol. Section Title Doc Link 16538678 Disease Relevance 0.09 Pain Relevance 0.43

General Comments

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