INT68589

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.36
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cacna1c) nucleus (Cacna1c) transmembrane transport (Cacna1c)
cytoplasm (Cacna1c)
Anatomy Link Frequency
plasma 2
cardiomyocytes 1
RBC 1
brains 1
platelet 1
Cacna1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 30 100.00 Very High Very High Very High
anesthesia 5 96.28 Very High Very High Very High
Calcium channel 4 91.68 High High
alcohol 7 88.72 High High
Inflammation 38 83.00 Quite High
Arthritis 17 79.76 Quite High
fibrosis 23 78.24 Quite High
cva 8 76.40 Quite High
depression 10 74.48 Quite High
diclofenac 6 55.36 Quite High
Disease Link Frequency Relevance Heat
Anaemia 51 99.46 Very High Very High Very High
Heart Disease 16 99.28 Very High Very High Very High
Parasitemia 21 98.88 Very High Very High Very High
Arthritis 51 97.80 Very High Very High Very High
Liver Disease 5 93.84 High High
Critical Illness 46 93.72 High High
Weight Loss 4 93.40 High High
Appetite Loss 5 92.64 High High
Alcohol Addiction 5 91.52 High High
Thalassemia 13 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Mann-Whitney U test was used to compare parasitemia levels, the drop in relative temperature, the relative RBC density, BBB integrity and parasite and cytokine gene expression among brains collected from both naïve animals and infected mice.
Gene_expression (expression) of RBC in brains associated with parasitemia and cytokine
1) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518956 Disease Relevance 0.23 Pain Relevance 0.05
1A-AR-AB to neonatal cardiomyocytes affected intracellular Ca2+ at two different levels, namely the acute, short-term elevation of intracellular Ca2+, and the increased transcript expression of Cacna1c [5].
Gene_expression (expression) of Cacna1c in cardiomyocytes
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.51 Pain Relevance 0.08
There was a significant i) decrease in RBC count and haemoglobin, ii) increase in WBC count and ESR of arthritic rats, when compared with the control rats.
Gene_expression (count) of RBC associated with arthritis
3) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2978115 Disease Relevance 1.28 Pain Relevance 0.11
Rat RBC were labeled ex vivo with 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate and then infused intravenously.
Gene_expression (labeled) of RBC in RBC
4) Confidence 0.23 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9087623 Disease Relevance 0 Pain Relevance 0.10
An even more significant association was found between abnormal RBC cholinesterase levels and selling pesticide containers (p = 0.008).
Gene_expression (levels) of RBC
5) Confidence 0.14 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.80 Pain Relevance 0.04
In addition, certain conditions other than pesticide exposure can lower plasma and RBC cholinesterase levels, confounding interpretation of test results.
Gene_expression (levels) of RBC in plasma
6) Confidence 0.14 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.60 Pain Relevance 0.04
After performing chi-square analysis to test for independence, significant association was found between selling pesticide containers and abnormal RBC cholinesterase levels (P = 0.001), and mixing of pesticides with abnormal mean corpuscular volume (MCV) (Table 5).
Gene_expression (levels) of RBC
7) Confidence 0.14 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.07 Pain Relevance 0.04
In addition, certain conditions other than pesticide exposure can lower plasma and RBC cholinesterase levels, confounding interpretation of test results.
Gene_expression (plasma) of RBC in plasma
8) Confidence 0.14 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.59 Pain Relevance 0.04
Table 7 shows the predictors of abnormal RBC cholinesterase levels and abnormal MCV as dependent variables.
Gene_expression (levels) of RBC
9) Confidence 0.14 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0 Pain Relevance 0
Coagulation markers, including AT activity, fibrin/fibrinogen degradation products (FDP), and fibrinogen levels and red blood cell (RBC), white blood cell (WBC), and the platelet counts, were measured in the same samples.
Gene_expression (products) of RBC in platelet
10) Confidence 0.14 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.06 Pain Relevance 0.12
If we define normal haemoglobin as being greater than 115 g/l for women and greater than 125 g/l for men, then there is no evidence in the literature to justify maintaining such high concentrations by the use of RBC transfusions in any anaemic patient.
Gene_expression (transfusions) of RBC
11) Confidence 0.11 Published 2001 Journal Crit Care Section Body Doc Link PMC137267 Disease Relevance 0.59 Pain Relevance 0
Those investigators also found that the risk of anaemia appeared to decrease with RBC transfusion in patients with cardiac disease.
Gene_expression (transfusion) of RBC associated with anaemia and heart disease
12) Confidence 0.11 Published 2001 Journal Crit Care Section Body Doc Link PMC137267 Disease Relevance 1.05 Pain Relevance 0
The paired comparisons of these 91 residents showed significant improvements for RBC counts, HB, and hematocrit (HCT), as summarized in Table 3.
Gene_expression (counts) of RBC
13) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665423 Disease Relevance 0.29 Pain Relevance 0.04
We found significant differences in the exposed and nonexposed groups for RBC count and hemoglobin (HB) in both sexes, as summarized in Table 2.
Gene_expression (count) of RBC
14) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665423 Disease Relevance 0.29 Pain Relevance 0.04

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