INT68591

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.93
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYRP1)
Anatomy Link Frequency
brain 2
plasma 1
nociceptor 1
afferent neurons 1
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 23 100.00 Very High Very High Very High
Tetrahydrobiopterin 8 99.58 Very High Very High Very High
Analgesic 3 99.56 Very High Very High Very High
Nerve growth factor 13 99.48 Very High Very High Very High
Serotonin 8 99.32 Very High Very High Very High
Pain 24 99.16 Very High Very High Very High
nociceptor 11 98.12 Very High Very High Very High
bradykinin 5 98.06 Very High Very High Very High
antagonist 3 97.36 Very High Very High Very High
Inflammation 9 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Malaria 6 99.70 Very High Very High Very High
Pain 25 99.16 Very High Very High Very High
Hypersensitivity 2 98.72 Very High Very High Very High
INFLAMMATION 9 96.48 Very High Very High Very High
Cardiovascular Disease 1 95.32 Very High Very High Very High
Stress 7 92.68 High High
Disease 39 91.16 High High
Hypoxia 1 89.60 High High
Intervertebral Disk Degeneration 39 85.72 High High
Targeted Disruption 4 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of TRP channels by NGF signalling might specify the temperature sensitivity of afferent neurons embryonically.
Regulation (Regulation) of TRP in afferent neurons associated with nerve growth factor and trp channel
1) Confidence 0.44 Published 2009 Journal Cell Tissue Res. Section Abstract Doc Link 19387688 Disease Relevance 0.08 Pain Relevance 0.79
These studies delineate a biochemical mechanism through which bradykinin and NGF produce hypersensitivity and might explain how the activation of PLC signalling systems regulates other members of the TRP channel family.
Regulation (regulates) of TRP associated with trp channel, nerve growth factor, hypersensitivity and bradykinin
2) Confidence 0.44 Published 2001 Journal Nature Section Abstract Doc Link 11418861 Disease Relevance 0.20 Pain Relevance 0.64
In this review, we present a comprehensive summary of the literature regarding the TRP channel regulation by different protein kinases.
Regulation (regulation) of TRP associated with trp channel
3) Confidence 0.44 Published 2005 Journal Neurosignals Section Abstract Doc Link 16772730 Disease Relevance 0.18 Pain Relevance 0.22
The effect of oral administration of a tryptophan-free amino acid mixture or the same mixture containing tryptophan (Trp) on hippocampal serotonin (5-HT) extracellular levels was studied using in vivo brain microdialysis of freely moving rats.
Regulation (effect) of Trp in brain associated with serotonin
4) Confidence 0.39 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9087665 Disease Relevance 0 Pain Relevance 0.22
Previous studies have demonstrated that elevation in plasma [FFA] displaces Trp from binding to albumin and consequently increases the free-Trp:LNAA ratio into the plasma [17,18,30,31].
Regulation (displaces) of Trp in plasma
5) Confidence 0.28 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0.07 Pain Relevance 0.16
Precise regulation of the expression, localization, and function of the TRP channels is crucial for their sensory role in nociceptor terminals, particularly after inflammation, when they contribute to pain hypersensitivity by undergoing changes in translation and trafficking as well as diverse posttranslational modifications.
Regulation (regulation) of TRP in nociceptor associated with inflammation, trp channel, nociceptor, hypersensitivity and stimulus evoked pain
6) Confidence 0.26 Published 2005 Journal Neuron Section Abstract Doc Link 15820689 Disease Relevance 0.46 Pain Relevance 0.47
Stretching without prior deactivation may increase TrP sensitivity.
Regulation (sensitivity) of TrP
7) Confidence 0.26 Published 2003 Journal Acupunct Med Section Abstract Doc Link 14620302 Disease Relevance 0.43 Pain Relevance 0.30
Using kinetic parameters of NAA transport at human blood-brain barrier (BBB), we showed that malaria significantly altered calculated brain uptake of His (+30%), Phe (+96%), Trp (-30%) and Ile (-27%), with no change in the other NAA, compared with controls.
Regulation (altered) of Trp in brain associated with malaria
8) Confidence 0.26 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11145003 Disease Relevance 0.72 Pain Relevance 0.24
This review evaluates current evidence that supports particular TRP channels as targets for novel analgesic drugs, along with potential adverse effects that may limit drug development.
Regulation (targets) of TRP associated with trp channel and analgesic
9) Confidence 0.26 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19442187 Disease Relevance 0.66 Pain Relevance 1.24
Regulation of TRP channels by phosphorylation.
Regulation (Regulation) of TRP associated with trp channel
10) Confidence 0.26 Published 2005 Journal Neurosignals Section Title Doc Link 16772730 Disease Relevance 0.17 Pain Relevance 0.21
Elucidating the mechanisms regulating the different endothelial TRP channels, and the associated development of drugs selectively to target the different isoforms, as a means to treat cardiovascular disease should, therefore, be a high priority.
Regulation (regulating) of TRP associated with trp channel and cardiovascular disease
11) Confidence 0.11 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16254217 Disease Relevance 0.46 Pain Relevance 0.28
As expected, kinetics with BH4 resulted in a lower resolution of the Km(Trp) values of the four TPH2 variants (Table 2), but revealed major differences in the relative maximal velocities (Vmax) of the corresponding enzymes.
Regulation (resolution) of Trp associated with tetrahydrobiopterin
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.10
Because Trp is rarely found in collagenous domains, there are no Trp residues in the collagenous domains of collagen IX in humans or in the mouse 14.
Neg (no) Regulation (residues) of Trp
13) Confidence 0.04 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.50 Pain Relevance 0
A range of other signals are known to be involved in regulating TRP channel function.
Regulation (regulating) of TRP associated with trp channel
14) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.18

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