INT68592

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.75
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 2
heart 1
midline 1
asa (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 31 100.00 Very High Very High Very High
Antinociceptive 5 100.00 Very High Very High Very High
narcan 3 99.98 Very High Very High Very High
Morphine 1 99.80 Very High Very High Very High
cINOD 8 98.44 Very High Very High Very High
Serotonin 2 94.12 High High
alcohol 18 87.20 High High
opiate 1 75.00 Quite High
anesthesia 54 69.60 Quite High
cva 3 69.56 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 17 100.00 Very High Very High Very High
Ventricular Heart Septal Defects 16 99.60 Very High Very High Very High
Hiatal Hernia 12 99.32 Very High Very High Very High
INFLAMMATION 9 93.96 High High
Sprains And Strains 25 87.84 High High
Alzheimer's Dementia 80 79.80 Quite High
Creutzfeldt Jakob Disease 50 76.24 Quite High
Toxicity 2 75.00 Quite High
Diabetes Mellitus 144 71.16 Quite High
Stroke 8 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with naloxone abolished the antinociceptive activity of both ASA and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-HT concentration and the reduction in 5-HT2 receptors in cortical membranes induced by ASA.
Negative_regulation (abolished) of ASA associated with aspirin, narcan, antinociceptive and morphine
1) Confidence 0.37 Published 1997 Journal Pharmacology Section Abstract Doc Link 9088041 Disease Relevance 0 Pain Relevance 0.90
CONCLUSION: In patients with historical ASA- or NSAID-induced urticaria-angioedema reactions but who did not have urticaria and angioedema independent of ASA/NSAID, rapid oral challenge-desensitization to ASA was performed safely and permitted patients with CAD and other diseases to receive treatment with ASA.


Negative_regulation (desensitization) of ASA
2) Confidence 0.37 Published 2000 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10808182 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The anti-platelet effect of EC-ASA 81 mg once daily was maintained following its co-administration with maximum OTC doses of NAPSO or acetaminophen.


Negative_regulation (effect) of EC-ASA in platelet
3) Confidence 0.24 Published 2010 Journal Curr Med Res Opin Section Body Doc Link 20429831 Disease Relevance 0 Pain Relevance 0
Forty-six samples were analyzed for the presence of prions both by neuropathology and the ASA; of these, 34 were positive by both methods, 11 were negative in both, and 1 was positive in the ASA but negative by neuropathology (Table S4).
Negative_regulation (negative) of ASA
4) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2809756 Disease Relevance 0.43 Pain Relevance 0.12
Forty-six samples were analyzed for the presence of prions both by neuropathology and the ASA; of these, 34 were positive by both methods, 11 were negative in both, and 1 was positive in the ASA but negative by neuropathology (Table S4).
Negative_regulation (positive) of ASA
5) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2809756 Disease Relevance 0.41 Pain Relevance 0.12
Several studies evaluated determinants of complete heart block after ASA in an effort to identify a high risk group that would benefit from a PPM implantation prior to the procedure.
Negative_regulation (block) of ASA in heart associated with heart rate under development
6) Confidence 0.04 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2780820 Disease Relevance 0.94 Pain Relevance 0.18
Aspirin (ASA), an irreversible cyclooxygenase (COX) inhibitor, induces ventricular septal defect (VSD) and diaphragmatic hernia (DH) in rat fetuses when administered on gestation days (GDs) 9-10, a critical period for cardiovascular (CV) and midline development.
Negative_regulation (inhibitor) of ASA in midline associated with aspirin, hiatal hernia and ventricular heart septal defects
7) Confidence 0.02 Published 2005 Journal Drug Chem Toxicol Section Abstract Doc Link 16298872 Disease Relevance 0.74 Pain Relevance 0.36
Thus ASA resistance should be defined as the failure of ASA to block arachidonic acid-induced platelet aggregation, inhibiting production of platelet thromboxane A2.57 In the scientific literature, the term resistance has been applied to failure to prevent occurrence of atherothrombotic vascular events in patients taking ASA (or other antiplatelet agents).
Negative_regulation (failure) of ASA in platelet
8) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672443 Disease Relevance 0.36 Pain Relevance 0
In addition to inhibiting COX, ASA also inhibits carbonic anhydrase.
Negative_regulation (inhibiting) of ASA associated with aspirin
9) Confidence 0.01 Published 2005 Journal Drug Chem Toxicol Section Abstract Doc Link 16298872 Disease Relevance 0.88 Pain Relevance 0.42

General Comments

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