INT686

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 9.59
Pain Relevance 11.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
pancreas 3
spinal cord 2
right atrium 2
plasma 1
radius 1
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 20 100.00 Very High Very High Very High
tetrodotoxin 14 100.00 Very High Very High Very High
Bile 8 100.00 Very High Very High Very High
Cholecystokinin 6 100.00 Very High Very High Very High
Antinociceptive 6 100.00 Very High Very High Very High
Pain 8 99.98 Very High Very High Very High
Chronic pancreatitis 22 99.96 Very High Very High Very High
analgesia 6 99.96 Very High Very High Very High
narcan 1 99.84 Very High Very High Very High
substance P 3 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 6 99.98 Very High Very High Very High
Pancreatitis 23 99.96 Very High Very High Very High
Duodenal Ulcer 12 99.84 Very High Very High Very High
Infection 23 99.74 Very High Very High Very High
Deficiency Diseases 9 99.72 Very High Very High Very High
Ulcers 13 99.54 Very High Very High Very High
Disease 18 98.96 Very High Very High Very High
Gastrinoma 1 98.80 Very High Very High Very High
Monsters 2 97.64 Very High Very High Very High
Cancer 5 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although this positive chronotropic action of secretin was inhibited by D,L-propranolol, it was probably not mediated by the release of endogenous catecholamines as: a) the inhibitory effects of D- and L-propranolol were similar and b) the efficiency of secretin on the in vitro beating of right atrium was the same in control and reserpinized rats.
Negative_regulation (inhibited) of secretin in right atrium associated with catecholamine
1) Confidence 0.59 Published 1984 Journal Pflugers Arch. Section Abstract Doc Link 6540864 Disease Relevance 0 Pain Relevance 0.10
Evidence is reviewed that Helicobacter pylori infection may cause a deficiency of the hormone secretin that allows peptic ulcer disease to develop by impairing the body's defenses to gastric acid.
Negative_regulation (deficiency) of secretin in body associated with peptic ulcer disease, ulcers, disease and infection
2) Confidence 0.58 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18280672 Disease Relevance 0.47 Pain Relevance 0.13
The fact that not all patients with H. pylori infection develop peptic ulceration suggests that degree of secretin deficiency determined by extent of the infection must reach a critical level for peptic ulceration to occur.
Negative_regulation (deficiency) of secretin associated with infection
3) Confidence 0.58 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18280672 Disease Relevance 0.88 Pain Relevance 0.03
Decrease in plasma amino acid level after secretin and pancreozymin as an indicator of exocrine pancreatic function.
Negative_regulation (Decrease) of secretin in plasma associated with bile
4) Confidence 0.58 Published 1986 Journal Gastroenterology Section Title Doc Link 3949104 Disease Relevance 0.17 Pain Relevance 0.18
In chronic pancreatitis, secretin releasing response to acidification was markedly impaired, in addition, inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas.
Negative_regulation (impaired) of secretin in pancreas associated with chronic pancreatitis
5) Confidence 0.51 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.93 Pain Relevance 0.33
After 75Se-selenomethionine injection, the angle of the initial increase of radioactivity, the height of the plateau, and the reactive decrease of radioactivity after pancreozymin and secretin were analyzed in each case.
Negative_regulation (decrease) of secretin associated with bile
6) Confidence 0.49 Published 1975 Journal J. Nucl. Med. Section Abstract Doc Link 1113183 Disease Relevance 0.36 Pain Relevance 0.16
Met, Leu and their D-ala2-analogs inhibited both basal and pH 4.5-stimulated secretin.
Negative_regulation (inhibited) of secretin
7) Confidence 0.49 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.48
Bilateral truncal vagotomy also significantly diminished gastric motor responses to secretin.
Negative_regulation (diminished) of secretin
8) Confidence 0.43 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7611400 Disease Relevance 0 Pain Relevance 0.06
From these results, it is suggested that the medial amygdaloid nucleus plays a stimulatory role in pancreatic exocrine secretion via vagus nerves and that a certain level of plasma secretin is needed for the medial amygdaloid stimulation to be effective.
Negative_regulation (effective) of secretin in medial
9) Confidence 0.43 Published 1994 Journal Pancreas Section Abstract Doc Link 8108364 Disease Relevance 0 Pain Relevance 0
Peptic ulceration may be a hormonal deficiency disease, a result of secretin deficiency caused by H. pylori infection.
Negative_regulation (deficiency) of secretin associated with deficiency diseases and infection
10) Confidence 0.43 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18280672 Disease Relevance 0.86 Pain Relevance 0.03
Secretin stimulated the force of contraction of spontaneously beating right atrium, even in the presence of propranolol, i.e. when the chronotropic effect of secretin was abolished.
Negative_regulation (abolished) of secretin in right atrium
11) Confidence 0.43 Published 1984 Journal Pflugers Arch. Section Abstract Doc Link 6540864 Disease Relevance 0 Pain Relevance 0.13
When 5,7 DHT was administered alone, either i.c.v. or i.t., without protection of the catecholaminergic neurons so that noradrenaline (NA) was greatly reduced, the antinociceptive effect of sCT was completely abolished even when NA had been depleted only in the spinal cord.
Negative_regulation (abolished) of sCT in spinal cord associated with noradrenaline, antinociceptive and spinal cord
12) Confidence 0.42 Published 1986 Journal Neuropeptides Section Abstract Doc Link 2946979 Disease Relevance 0 Pain Relevance 0.47
It is suggested that the secretin release was impaired in duodenal ulcer in spite of hypersecretion of gastric acids.
Negative_regulation (impaired) of secretin associated with duodenal ulcer
13) Confidence 0.42 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.92 Pain Relevance 0.32
In chronic pancreatitis, secretin releasing response to acidification was markedly impaired, in addition, inhibition of secretin release by bicarbonate was diminished due to a lack of bicarbonate flow from the pancreas.
Negative_regulation (inhibition) of secretin in pancreas associated with chronic pancreatitis
14) Confidence 0.42 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.92 Pain Relevance 0.33
We conclude that increase in pancreatic blood flow is not a physiological effect of secretin.
Negative_regulation (effect) of secretin in blood
15) Confidence 0.42 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6889320 Disease Relevance 0 Pain Relevance 0.19
PPJ was collected from within the main pancreatic duct by endoscopic retrograde catheterization of the papilla after a rapid intravenous injection of secretin and CCK-PZ.
Negative_regulation (injection) of secretin in papilla
16) Confidence 0.42 Published 1982 Journal Gastroenterol. Jpn. Section Abstract Doc Link 6217103 Disease Relevance 0.88 Pain Relevance 0.88
Lignocaine reduced pancreatic secretion with secretin alone, and stimulated it during infusion of atropine.
Negative_regulation (reduced) of secretin
17) Confidence 0.42 Published 1985 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 4020032 Disease Relevance 0.06 Pain Relevance 0.26
Moreover, the action of CAP on secretin release was significantly inhibited in the recipient rats pretreated with TTX, BSV, and topical applications of capsaicin but was not suppressed in the recipient rats pretreated with atropine, hexamethonium, or propranolol.
Neg (not) Negative_regulation (suppressed) of secretin associated with tetrodotoxin and qutenza
18) Confidence 0.40 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.55
Moreover, the action of CAP on secretin release was significantly inhibited in the recipient rats pretreated with TTX, BSV, and topical applications of capsaicin but was not suppressed in the recipient rats pretreated with atropine, hexamethonium, or propranolol.
Negative_regulation (inhibited) of secretin associated with tetrodotoxin and qutenza
19) Confidence 0.40 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.54
Stimulation of PES and inhibition of gastric acid secretion and motility by secretin in a physiological dose are also dependent on the vagal afferent pathway as these effects of secretin are abolished by perivagal capsaicin treatment or vagotomy.
Negative_regulation (abolished) of secretin associated with qutenza
20) Confidence 0.40 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075453 Disease Relevance 0 Pain Relevance 0.68

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