INT68635

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.16
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ceacam3) cellular_component (Ceacam3) biological_process (Ceacam3)
Anatomy Link Frequency
CeA 5
neurons 2
visceral 1
Ceacam3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 258 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
gABA 2 100.00 Very High Very High Very High
Visceral pain 11 99.98 Very High Very High Very High
Ventral tegmentum 11 99.92 Very High Very High Very High
anesthesia 11 99.56 Very High Very High Very High
agonist 6 99.14 Very High Very High Very High
Morphine 12 98.16 Very High Very High Very High
Pain 168 98.12 Very High Very High Very High
medulla 10 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

11 99.98 Very High Very High Very High
Eating Disorder 2 99.82 Very High Very High Very High
Hypersensitivity 2 98.92 Very High Very High Very High
Pain 169 98.12 Very High Very High Very High
Anxiety Disorder 17 97.72 Very High Very High Very High
Stress 6 92.24 High High
Depression 7 84.52 Quite High
Post-traumatic Stress Disorder 3 83.68 Quite High
Nociception 14 73.20 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

24 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the CeA decreased Fos expression in the BNSTv regardless of drug experience, whereas in the VTA this effect only occurred in morphine-treated rats.
Negative_regulation (Inhibition) of CeA in CeA associated with ventral tegmentum, amygdala and morphine
1) Confidence 0.55 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18831893 Disease Relevance 0 Pain Relevance 0.94
Systemic administration of the 5-HT1A receptor agonists 8-OH-DPAT and flesinoxan dose-dependently decreased 5-HT levels in the CeA.
Negative_regulation (decreased) of CeA in CeA associated with agonist and amygdala
2) Confidence 0.43 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9089665 Disease Relevance 0 Pain Relevance 0.59
In addition, feedforward inhibition of CeA neurons is driven by glutamatergic projections from the BLA area to a cluster of GABAergic neurons in the intercalated cell masses (ITC).
Negative_regulation (inhibition) of CeA in neurons associated with gabaergic and amygdala
3) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3016348 Disease Relevance 0.41 Pain Relevance 0.89
CeA inhibition modulates the footshock-induced activity of these regions of the brain and attenuates reinstatement of drug seeking behaviour.
Negative_regulation (inhibition) of CeA in CeA associated with amygdala
4) Confidence 0.40 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18831893 Disease Relevance 0 Pain Relevance 0.91
Finally, a possible relationship between food restriction-induced suppression of the kappa opioid mechanism in CeA/BSTLD, local CRH function, and sensitization of the neural substrate for incentive-motivating effects of abused drugs is discussed.
Negative_regulation (suppression) of CeA in CeA associated with amygdala, opioid and eating disorder
5) Confidence 0.38 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082881 Disease Relevance 0.18 Pain Relevance 0.82
In conclusion, suppression of cortical activation by general anesthesia during visceral pain attenuated the expression of CRF in the CeA, suggesting that the conscious recognition of pain at a cortical level is an important determinant of the involvement of CRF in the mechanisms of subcortical pain control.



Negative_regulation (attenuated) of CeA in visceral associated with pain, visceral pain, anesthesia and amygdala
6) Confidence 0.38 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.73 Pain Relevance 0.82
Activation of inhibitory ITC neurons and subsequent inhibition of CeA neurons has been suggested to play an important role in fear extinction [2,35].
Negative_regulation (inhibition) of CeA in neurons associated with anxiety disorder and amygdala
7) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.72 Pain Relevance 1.06
Conversely, in normal animals ERK activation in the CeLC [35], corticosterone delivery to the CeA [36] and block of GABA-A receptors in the CeA [33] increased peripheral hypersensitivity, although it was not clear if these effects correlated positively with amygdala activity.
Negative_regulation (block) of CeA in amygdala associated with gaba, hypersensitivity and amygdala
8) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.82 Pain Relevance 1.81

General Comments

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