INT68638

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.63
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Hnmt) nucleus (Hnmt) cytoplasm (Hnmt)
Anatomy Link Frequency
brain 1
Hnmt (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 20 99.78 Very High Very High Very High
Pain 8 98.30 Very High Very High Very High
Antinociceptive 8 97.86 Very High Very High Very High
Pain threshold 8 96.68 Very High Very High Very High
Analgesic 8 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 16 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To verify whether SKF 91488-induced antinociception is due to inhibition of histamine-N-methyltransferase, (R)-alpha-methylhistamine, described to block histamine release and synthesis by stimulating the histamine H3-autoreceptor and activating the negative feed-back mechanism, was used.
Negative_regulation (inhibition) of histamine-N-methyltransferase associated with antinociception
1) Confidence 0.58 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9089666 Disease Relevance 0.24 Pain Relevance 0.65
The present data show that the antinociceptive effect previously described for metoprine is not restricted to this molecule, but is also shared by other histamine-N-methyl-transferase inhibitors.
Negative_regulation (inhibitors) of histamine-N-methyl-transferase associated with antinociceptive
2) Confidence 0.58 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9089666 Disease Relevance 0.14 Pain Relevance 0.56
In the present study, in order to corroborate the idea of inducing antinociception by inhibiting histamine catabolism, the effects of a noncompetitive histamine-N-methyltransferase inhibitor.
Negative_regulation (inhibitor) of histamine-N-methyltransferase associated with antinociception
3) Confidence 0.43 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9089666 Disease Relevance 0.15 Pain Relevance 0.47
We have previously reported that the histaminergic system is involved in the control of pain perception, and that substances able to enhance histamine brain levels, such as the histamine-N-methyltransferase inhibitor, metoprine, induce antinociception.
Negative_regulation (inhibitor) of histamine-N-methyltransferase in brain associated with antinociception and pain
4) Confidence 0.43 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9089666 Disease Relevance 0.10 Pain Relevance 0.36

General Comments

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