INT6864

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 110
Total Number 115
Disease Relevance 59.01
Pain Relevance 47.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 31
spinal cord 13
neuronal 10
retina 9
paw 8
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 763 100.00 Very High Very High Very High
Inflammation 708 100.00 Very High Very High Very High
allodynia 621 100.00 Very High Very High Very High
Pain 470 100.00 Very High Very High Very High
Hyperalgesia 141 100.00 Very High Very High Very High
nMDA receptor 52 100.00 Very High Very High Very High
Thermal hyperalgesia 33 100.00 Very High Very High Very High
Morphine 536 99.98 Very High Very High Very High
Spinal nerve ligature 304 99.98 Very High Very High Very High
Sciatic nerve 47 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1006 100.00 Very High Very High Very High
INFLAMMATION 807 100.00 Very High Very High Very High
Hyperalgesia 175 100.00 Very High Very High Very High
Cancer 68 100.00 Very High Very High Very High
Ocular Hypertension 475 99.98 Very High Very High Very High
Hypersensitivity 387 99.90 Very High Very High Very High
Hypertrophy 93 99.86 Very High Very High Very High
Cv Unclassified Under Development 180 99.84 Very High Very High Very High
Urological Neuroanatomy 158 99.84 Very High Very High Very High
Convulsion 58 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Positive_regulation (up-regulated) of Gene_expression (expression) of GFAP in molars
1) Confidence 0.70 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.36 Pain Relevance 0.23
Real-time RT-PCR indicated that GFAP expression was significantly increased in TNBS treated rats compared to the sham group.
Positive_regulation (increased) of Gene_expression (expression) of GFAP
2) Confidence 0.70 Published 2010 Journal Neuroscience Section Abstract Doc Link 20149842 Disease Relevance 1.47 Pain Relevance 1.49
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.
Positive_regulation (causes) of Gene_expression (expression) of GFAP in frontal cortex associated with urological neuroanatomy
3) Confidence 0.69 Published 2008 Journal Schizophr. Res. Section Title Doc Link 18585900 Disease Relevance 0.28 Pain Relevance 0.21
Morphine administration increased GFAP expression both in LC and NST as it was previously reported in other brain areas.
Positive_regulation (increased) of Gene_expression (expression) of GFAP in brain associated with morphine
4) Confidence 0.69 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.22 Pain Relevance 1.19
RESULTS: Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats.
Positive_regulation (increased) of Gene_expression (expression) of GFAP in brain
5) Confidence 0.69 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.08 Pain Relevance 0
The organometallic neurotoxicant, trimethyltin (TMT), is one such agent known to increase the production of GFAP as a consequence of widespread neuronal destruction.
Positive_regulation (increase) of Gene_expression (production) of GFAP in neuronal
6) Confidence 0.69 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.07 Pain Relevance 0.16
The enhanced production of glial fibrillary acidic protein (GFAP) by astroglia appears to be a general response of the CNS to many types of toxic insult.
Positive_regulation (enhanced) of Gene_expression (production) of GFAP
7) Confidence 0.69 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.07 Pain Relevance 0.07
The induction of GFAP expression by seizures may reflect the first step in a process in which seizures induce astrocytic hypertrophy.
Positive_regulation (induction) of Gene_expression (expression) of GFAP associated with hypertrophy and convulsion
8) Confidence 0.69 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.06 Pain Relevance 0.15
The present report describes another consequence of seizures-a dramatic induction of glial fibrillary acidic protein (GFAP) expression in astrocytes.
Positive_regulation (induction) of Gene_expression (expression) of GFAP in astrocytes associated with convulsion
9) Confidence 0.69 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 0.82 Pain Relevance 0.03
In immunohistochemical studies, astrocytes and microglia in rats with spinal hemisection showed significantly increased GFAP and OX-42 expression in both superficial and deep dorsal horns in the lumbar spinal dorsal horn compared to sham controls (* P<0.05) that was prevented in a dose-related manner by PPF.
Positive_regulation (increased) of Gene_expression (expression) of GFAP in spinal associated with spinal dorsal horn
10) Confidence 0.67 Published 2009 Journal Neuroscience Section Abstract Doc Link 19332108 Disease Relevance 0.69 Pain Relevance 0.91
Histologic examination of GFAP labeled astrocytes revealed increases in relative number of positively stained cells, which correlated with the increasing GFAP levels detected in the Western blot analysis.
Positive_regulation (increasing) of Gene_expression (detected) of GFAP in astrocytes
11) Confidence 0.67 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1899521 Disease Relevance 0.17 Pain Relevance 0.04
Both K and F treatments appeared to increase GFAP expression, although their effects were not additive.
Positive_regulation (increase) of Gene_expression (expression) of GFAP
12) Confidence 0.64 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2527299 Disease Relevance 0.85 Pain Relevance 0.48
Cortical expression of glial fibrillary acidic protein (GFAP) was elevated in F, K and KF vs.
Positive_regulation (elevated) of Gene_expression (expression) of glial fibrillary acidic protein
13) Confidence 0.64 Published 2008 Journal Behav Brain Funct Section Abstract Doc Link PMC2527299 Disease Relevance 0.51 Pain Relevance 0.30
SP induced a gradual increase at 10(-7) mol/L in the expression of GFAP in the spinal cord astrocytes at 0 -72 h, significantly different from that of the control group (P < 0.01), and it promoted the excretion of TNF-alpha and IL-1beta and the activity of NO and NOS at 10(-9) - 10(-6) mol/L at 12 h in a concentration-dependent manner, with marked differences between the experiment and control groups (P < 0.01, P < 0.05).
Positive_regulation (induced) of Gene_expression (expression) of GFAP in spinal cord
14) Confidence 0.63 Published 2009 Journal Zhonghua Nan Ke Xue Section Body Doc Link 20218316 Disease Relevance 0 Pain Relevance 0
The observed increases in GFAP/CD3/CD11B expression and astrocyte cell volume in spinal cord sections from animals chronically administered intrathecal morphine are consistent with gliosis and are in agreement with previous findings of astrocyte and microglial activation by chronic morphine administration [19,28-30].
Positive_regulation (increases) of Gene_expression (expression) of GFAP in astrocyte associated with gliosis, morphine, intrathecal and spinal cord
15) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.59 Pain Relevance 0.95
Therefore, ultra-low dose naltrexone significantly attenuated the increase in GFAP and CD3/CD11B expression induced by chronic morphine administration.


Positive_regulation (increase) of Gene_expression (expression) of GFAP associated with morphine
16) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.16 Pain Relevance 0.84
As no significant difference was found in the number of immuno-positive cells or in the number of newly generated cells between morphine treated and saline controls, glial proliferation likely contributes very little to the observed increases in GFAP and CD3/CD11B expression.
Neg (little) Positive_regulation (increases) of Gene_expression (expression) of GFAP associated with morphine
17) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.51 Pain Relevance 0.87
Co-administration of ultra-low dose naltrexone in combination with morphine did not produce a significant increase in GFAP expression as compared to saline-treated and naltrexone-treated controls (P > 0.05).
Positive_regulation (increase) of Gene_expression (expression) of GFAP associated with morphine
18) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.12 Pain Relevance 0.93
ET-1 injection also resulted in an increase in GFAP (Figure 4A, 380±100%, p<0.005) and similarly, elevation of IOP increased GFAP expression in all screened rats (133±10%, p<0.005, Figure 4B,C, n=6).
Positive_regulation (increased) of Gene_expression (expression) of GFAP associated with ocular hypertension
19) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.96 Pain Relevance 0
Furthermore, Lau et al. have shown that intravitreal ET injection increased GFAP expression in rat retina [63].
Positive_regulation (increased) of Gene_expression (expression) of GFAP in retina
20) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.92 Pain Relevance 0

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