INT68649

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Context Info
Confidence 0.72
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 6.70
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL24) extracellular region (IL24)
Anatomy Link Frequency
lung 2
IL24 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
imagery 2 100.00 Very High Very High Very High
palliative 1 99.64 Very High Very High Very High
cINOD 30 99.28 Very High Very High Very High
Neuropathic pain 2 99.04 Very High Very High Very High
neuralgia 1 93.76 High High
Inflammation 29 86.68 High High
Trigeminal neuralgia 4 75.00 Quite High
Cannabinoid receptor 2 75.00 Quite High
medulla 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 92 100.00 Very High Very High Very High
Cancer 73 99.84 Very High Very High Very High
Depression 48 99.12 Very High Very High Very High
Neuropathic Pain 2 99.04 Very High Very High Very High
Lung Cancer 254 97.92 Very High Very High Very High
Renal Cancer 9 96.92 Very High Very High Very High
Headache 5 93.76 High High
Muscular Spasm 1 92.76 High High
INFLAMMATION 44 91.20 High High
Skin Cancer 7 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pulse-chase experiments showed that the increased expression of MDA-7 protein in sulindac-treated cells was due to increased half-life of the MDA-7 protein.
Gene_expression (expression) of MDA-7 protein
1) Confidence 0.72 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15713900 Disease Relevance 1.00 Pain Relevance 0.05
Sulindac increased expression of ectopic MDA-7 protein in tumor cells, thereby increasing the expression of downstream effectors RNA-dependent protein kinase, p38MAPK, caspase-9, and caspase-3 and enhancing apoptosis of non-small cell lung cancer cells.
Gene_expression (expression) of MDA-7 protein in lung associated with lung cancer, cancer and apoptosis
2) Confidence 0.72 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15713900 Disease Relevance 1.02 Pain Relevance 0.06
Indeed, an NSAID has been shown to increase ectopic expression of IL-24 that augmented adenovirus delivery leading to the proposed use of more than one inducer of IL-24 to achieve superphysiological levels of this pro-apoptotic factor in tumors [35].
Gene_expression (expression) of IL-24 associated with cancer, cinod and apoptosis
3) Confidence 0.71 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.85 Pain Relevance 0.36
g/ml Onconase showed remarkably consistent up-regulated expression of IL-24 as well as of ATF3 and IL-6 (Figure 4A).
Gene_expression (expression) of IL-24
4) Confidence 0.71 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.48 Pain Relevance 0
Haplotype analysis of the IL10, IL19, IL20, and IL24 genes was performed according to the pairwise linkage disequilibrium pattern observed within each of these genes (cases + controls, n = 429).
Gene_expression (analysis) of IL24
5) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.28 Pain Relevance 0
ATF3 expression increased from 3-fold to more than 400-fold, IL-24 from 2- to nearly 1000-fold, and IL-6 from 2- to nearly 100-fold.
Gene_expression (expression) of IL-24
6) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.51 Pain Relevance 0.03
Therefore, we tested the antitumor activity of an adenoviral vector expressing mda-7 (Ad-mda7) in combination with sulindac against non-small cell lung cancer cells in vitro and in vivo.
Gene_expression (expressing) of adenoviral vector expressing mda-7 in lung associated with lung cancer
7) Confidence 0.55 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15713900 Disease Relevance 0.69 Pain Relevance 0.09
Among the five genes tested, the gene encoding the pro-apoptotic factor IL-24 is noteworthy in that its expression increased with time in three of four cell lines.
Gene_expression (expression) of pro-apoptotic factor IL-24 associated with apoptosis
8) Confidence 0.54 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.54 Pain Relevance 0
Compound 15 (MDA55) (K(i) = 89.9 nM, EC(50) = 88.2 nM at CB2) inhibited the effect of compound 1 (MDA7), a selective CB2 agonist, in an animal model of neuropathic pain.
Gene_expression (agonist) of MDA7 associated with neuropathic pain and agonist
9) Confidence 0.48 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19115816 Disease Relevance 0.10 Pain Relevance 0.34
Compound 15 (MDA55) (K(i) = 89.9 nM, EC(50) = 88.2 nM at CB2) inhibited the effect of compound 1 (MDA7), a selective CB2 agonist, in an animal model of neuropathic pain.
Gene_expression (effect) of MDA7 associated with neuropathic pain and agonist
10) Confidence 0.48 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19115816 Disease Relevance 0.10 Pain Relevance 0.34
The examination consisted of 3D time-of-flight MRA (3d TOF) protocol, with a FISP sequence (Fast Imaging Steady Precession) and magnetization transfer.
Gene_expression (transfer) of FISP associated with imagery
11) Confidence 0.08 Published 1996 Journal J Neuroradiol Section Abstract Doc Link 9091607 Disease Relevance 0.47 Pain Relevance 0.33
MDA-7 (interleukin-24), when expressed via a recombinant replication defective adenovirus, Ad.mda-7, has profound antiproliferative and cytotoxic effects in a wide variety of tumor cells but not in nontransformed cells.
Gene_expression (expressed) of interleukin-24 associated with cancer
12) Confidence 0.08 Published 2003 Journal Mol. Cancer Ther. Section Abstract Doc Link 12883035 Disease Relevance 0.67 Pain Relevance 0.10

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