INT68652

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 4.95
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
lymph node 4
monocytes 3
T cells 2
neutrophils 1
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 100.00 Very High Very High Very High
aspirin 9 99.48 Very High Very High Very High
metalloproteinase 7 98.14 Very High Very High Very High
cytokine 8 87.84 High High
Inflammation 13 87.44 High High
Paracetamol 3 78.68 Quite High
Endocannabinoid 1 76.36 Quite High
opioid receptor 2 75.00 Quite High
cINOD 4 66.56 Quite High
Analgesic 2 50.56 Quite High
Disease Link Frequency Relevance Heat
Metastasis 27 99.84 Very High Very High Very High
Hypoxia 8 99.16 Very High Very High Very High
Melanoma 146 98.80 Very High Very High Very High
Apoptosis 137 91.92 High High
Cancer 108 90.44 High High
Necrosis 6 88.48 High High
INFLAMMATION 14 87.44 High High
Colon Cancer 4 77.32 Quite High
Brain Tumor 2 73.80 Quite High
Infection 28 71.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Spec (investigated) Regulation (effects) of Spec (investigated) Positive_regulation (activation) of activator protein 1 in monocytes associated with morphine
1) Confidence 0.54 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
Hypoxia can promote lymph node metastasis via up-regulation of PLAUR [39], and up-regulation of HIF1a, JUN and PLAUR in our invasive cell lines hints at possible activation of JUN/AP1 and HIF/ARNT pathways in melanoma (Figure 5).
Regulation (regulation) of Spec (possible) Positive_regulation (activation) of JUN in lymph node associated with melanoma, hypoxia and metastasis
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.66 Pain Relevance 0
Hypoxia can promote lymph node metastasis via up-regulation of PLAUR [39], and up-regulation of HIF1a, JUN and PLAUR in our invasive cell lines hints at possible activation of JUN/AP1 and HIF/ARNT pathways in melanoma (Figure 5).
Regulation (regulation) of Spec (possible) Positive_regulation (activation) of JUN in lymph node associated with melanoma, hypoxia and metastasis
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.73 Pain Relevance 0
This effect was specific, as the activity of nuclear factor kappabeta, nuclear factor of activated T cells, and specific protein-1 was not altered and several other volatile anesthetics studied did not affect AP-1 activation.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (activation) of AP-1 in T cells
4) Confidence 0.27 Published 2004 Journal Anesthesiology Section Body Doc Link 15329596 Disease Relevance 0 Pain Relevance 0
The inhibition effects on the activation of AP-1 activity by aspirin and aspirin-like salicylates may further explain the anti-carcinogenesis mechanism of action of these drugs.
Regulation (effects) of Positive_regulation (activation) of AP-1 associated with aspirin
5) Confidence 0.22 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092536 Disease Relevance 0.64 Pain Relevance 0.37
In this study, we investigated the effects of morphine and nitric oxide on CD14 expression and activator protein 1 activation in human blood monocytes and neutrophils as well as the leukocyte cell line HL-60.
Spec (investigated) Regulation (effects) of in neutrophils Spec (investigated) Positive_regulation (activation) of activator protein 1 in monocytes associated with morphine
6) Confidence 0.18 Published 2007 Journal Eur J Anaesthesiol Section Abstract Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.21
To further characterize the biochemical inhibitory mechanisms of AM404, we examined the signaling pathways that regulate the activation of the transcription factors NF-kappaB, NFAT and AP-1 in Jurkat cells.
Spec (examined) Regulation (regulate) of Spec (examined) Positive_regulation (activation) of AP-1
7) Confidence 0.18 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17196940 Disease Relevance 0 Pain Relevance 0.19
Therefore, the induction of JUN most likely had a significant effect on the expression of p53 in infected cells.
Regulation (effect) of Positive_regulation (induction) of JUN
8) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.60 Pain Relevance 0
, transrepress the activity of other transcription factors like AP-1 and NF-?
Spec (like) Regulation (activity) of Positive_regulation (factors) of AP-1
9) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0.07 Pain Relevance 0.06
Interestingly, we found that GlcN inhibits matrix metalloproteinase production by inhibiting the phosphorylation of the mitogen-activated protein (MAP) kinases involved in the activation of activator protein-1 (AP-1) transcription factor complex [14].
Regulation (involved) of Positive_regulation (activation) of AP-1 associated with metalloproteinase
10) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0.26 Pain Relevance 0.20

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