INT6866

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2011
Negated 21
Speculated 7
Reported most in Abstract
Documents 51
Total Number 58
Disease Relevance 19.60
Pain Relevance 23.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 5
neuronal 3
striatum 2
hippocampus 2
neural 2
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 51 100.00 Very High Very High Very High
antagonist 38 100.00 Very High Very High Very High
Dopamine 24 100.00 Very High Very High Very High
Gabapentin 4 100.00 Very High Very High Very High
medulla 61 99.84 Very High Very High Very High
Morphine 87 99.82 Very High Very High Very High
Nerve growth factor 69 99.80 Very High Very High Very High
depression 2 99.78 Very High Very High Very High
Ventral tegmentum 46 99.68 Very High Very High Very High
cerebral cortex 28 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 107 100.00 Very High Very High Very High
Depression 4 99.78 Very High Very High Very High
Urological Neuroanatomy 61 99.68 Very High Very High Very High
Injury 360 99.56 Very High Very High Very High
Ocular Hypertension 230 98.98 Very High Very High Very High
Spinal Cord Injury 67 98.72 Very High Very High Very High
Diabetes Mellitus 8 98.48 Very High Very High Very High
Sprains And Strains 191 98.44 Very High Very High Very High
Toxicity 3 97.64 Very High Very High Very High
Gliosis 40 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No alterations in GFAP levels were observed in response to chronic morphine in several other regions of the CNS studied, including the substantia nigra, locus coeruleus, cerebral cortex, and spinal cord.
Neg (No) Regulation (alterations) of GFAP in locus coeruleus associated with locus ceruleus, substantia nigra, cerebral cortex, spinal cord and morphine
1) Confidence 0.61 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8228992 Disease Relevance 0.29 Pain Relevance 1.20
Comparable changes in GFAP and NGF could be achieved by treatment of control cultures with interferon-gamma or interleukin-1 beta.
Regulation (changes) of GFAP associated with nerve growth factor
2) Confidence 0.60 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7532097 Disease Relevance 0.17 Pain Relevance 0.42
We conclude that (a) the non-adrenergic imidazoline binding sites are expressed in astrocytes but not in neurons in rat cerebral cortex and (b) these "receptors" may influence astrocyte physiology by regulating the levels of GFAP.
Regulation (regulating) of GFAP in astrocytes associated with cerebral cortex
3) Confidence 0.59 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8315666 Disease Relevance 0 Pain Relevance 0.15
However, Dorman et al. (2004) did not find any evidence of changes in GFAP levels in the brain after
Regulation (changes) of GFAP in brain
4) Confidence 0.57 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552007 Disease Relevance 0.07 Pain Relevance 0.03
No up-regulation of GFAP was detected in PVG rats in any compartment (Table 1).


Neg (No) Regulation (regulation) of GFAP
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.36 Pain Relevance 0
Tanihara et al. [60] have shown that elevation of IOP in primates was accompanied by increased GFAP mRNA and Yu et al. [61] observed elevation of IOP increased GFAP protein levels without significant changes in GFAP mRNA levels.
Neg (without) Regulation (changes) of GFAP mRNA associated with ocular hypertension
6) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.11 Pain Relevance 0
The data in Fig. 7 reveal that binge MDMA treatment does not affect GFAP, while 5,7-DHT increases levels of this protein.
Neg (not) Regulation (affect) of GFAP
7) Confidence 0.49 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0.24 Pain Relevance 0.04
No significant changes in the distribution or relative levels of GFAP mRNA expression, relative levels of GFAP protein or immunoreactivity for GFAP were found in the ipsilateral vestibular nuclei at any post-TTX injection times studied.
Neg (No) Regulation (changes) of GFAP protein associated with tetrodotoxin
8) Confidence 0.45 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.40
The present study extends this observation by showing that astrocytes in the rat lateral geniculate nucleus (LGN) also increase their immunoreactivity for glial fibrillary acidic protein (GFAP) soon after deprivation of afferent visual neuronal activity.
Regulation (immunoreactivity) of GFAP in astrocytes
9) Confidence 0.45 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874503 Disease Relevance 0 Pain Relevance 0.10
The present study extends this observation by showing that astrocytes in the rat lateral geniculate nucleus (LGN) also increase their immunoreactivity for glial fibrillary acidic protein (GFAP) soon after deprivation of afferent visual neuronal activity.
Regulation (immunoreactivity) of glial fibrillary acidic protein in astrocytes
10) Confidence 0.45 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874503 Disease Relevance 0 Pain Relevance 0.10
CONCLUSION: EA can effectively suppress CCI-induced up-regulation of expression of spinal GFAP, TNF-alpha mRNA and IL-1beta mRNA, which may contribute to its effect in reducing mechanical allodynia and thermal hyperalgesia in neuropathic pain rats.


Regulation (regulation) of GFAP in spinal
11) Confidence 0.45 Published 2010 Journal Zhen Ci Yan Jiu Section Body Doc Link 20458900 Disease Relevance 0.16 Pain Relevance 0
AIM: To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S100B] in different brain regions of diabetic rats.
Spec (investigate) Regulation (effect) of GFAP in neural associated with diabetes mellitus and gabapentin
12) Confidence 0.45 Published 2005 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15780189 Disease Relevance 0.17 Pain Relevance 0.21
AIM: To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S100B] in different brain regions of diabetic rats.
Spec (investigate) Regulation (effect) of glial fibrillary acidic protein in neural associated with diabetes mellitus and gabapentin
13) Confidence 0.45 Published 2005 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 15780189 Disease Relevance 0.17 Pain Relevance 0.21
No significant changes in the distribution or relative levels of GFAP mRNA expression, relative levels of GFAP protein or immunoreactivity for GFAP were found in the ipsilateral vestibular nuclei at any post-TTX injection times studied.
Neg (No) Regulation (changes) of GFAP associated with tetrodotoxin
14) Confidence 0.44 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.41
In the present study, we aimed to examine the potential protective effect of yohimbine, a alpha(2)-adrenoceptor antagonist, against glial fibrillary acidic protein (GFAP) alterations elicited by chronic morphine treatment.
Spec (examine) Regulation (effect) of GFAP associated with antagonist and morphine
15) Confidence 0.44 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15936527 Disease Relevance 0.08 Pain Relevance 0.71
The most marked changes in albumin and GFAP immunoreaction were seen after 2 weeks and persisted with mild intensities even after 10 weeks.
Regulation (changes) of GFAP
16) Confidence 0.42 Published 2006 Journal Pain Section Abstract Doc Link 16806707 Disease Relevance 0.08 Pain Relevance 0.32
Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area.
Regulation (regulation) of Glial fibrillary acidic protein in ventral associated with ventral tegmentum, dopamine, sprains and strains and morphine
17) Confidence 0.39 Published 1993 Journal J. Neurochem. Section Title Doc Link 8228992 Disease Relevance 0.30 Pain Relevance 1.06
In the trigeminal ganglia and the brain stem up-regulation of GFAP positive staining was visible from 3 dpi.
Regulation (regulation) of GFAP in trigeminal ganglia
18) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.38 Pain Relevance 0
Changes in GFAP ir and in the morphology of astrocytes within the spinal cord after peripheral nerve injury are depicted in Fig 5A.
Regulation (Changes) of GFAP in astrocytes associated with nervous system injury, peripheral nerve injury and spinal cord
19) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2669449 Disease Relevance 0.58 Pain Relevance 0.32
On the contralateral side, the immunoreactivities for both CD11b and GFAP were unchanged among the CCI rats with each treatment (Figure 3b and 3c).


Neg (unchanged) Regulation (unchanged) of GFAP associated with injury
20) Confidence 0.33 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022746 Disease Relevance 0.44 Pain Relevance 0.40

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