INT68661

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 9.60
Pain Relevance 5.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (NTSR1) endoplasmic reticulum (NTSR1) plasma membrane (NTSR1)
signal transducer activity (NTSR1)
Anatomy Link Frequency
PC-3 1
NTSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 30 99.92 Very High Very High Very High
analgesia 12 99.82 Very High Very High Very High
agonist 24 99.48 Very High Very High Very High
Dorsal horn 10 96.96 Very High Very High Very High
antinociception 2 96.96 Very High Very High Very High
intrathecal 138 93.24 High High
Antinociceptive 2 92.72 High High
Antihyperalgesic 2 91.88 High High
antiallodynic 2 91.16 High High
allodynia 4 90.20 High High
Disease Link Frequency Relevance Heat
Cancer 85 100.00 Very High Very High Very High
Stomach Cancer 27 99.76 Very High Very High Very High
Metastasis 15 99.36 Very High Very High Very High
Prostate Cancer 15 99.22 Very High Very High Very High
INFLAMMATION 17 99.20 Very High Very High Very High
Contagious Ecthyma 3 98.88 Very High Very High Very High
Apoptosis 14 97.76 Very High Very High Very High
Death 10 96.36 Very High Very High Very High
Adenocarcinoma 6 96.28 Very High Very High Very High
Disease 8 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The incubation of cells for 6 h with the NT agonist, JMV 449, resulted in an increase of 270% in NTR mRNA levels.
Positive_regulation (increase) of NTR mRNA associated with agonist
1) Confidence 0.69 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092553 Disease Relevance 0.10 Pain Relevance 0.16
In addition, the transcriptional activation of the NTR gene was dependent on NT-receptor complex internalization and de novo protein synthesis.
Positive_regulation (activation) of NTR gene
2) Confidence 0.69 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092553 Disease Relevance 0.09 Pain Relevance 0.16
In this case, a decrease of 70% was detected in NTR mRNA levels.
Positive_regulation (detected) of NTR mRNA
3) Confidence 0.50 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9092553 Disease Relevance 0.08 Pain Relevance 0.16
CGX-1160 is a conopeptide-based drug that produces analgesia through activation of the neurotensin receptor type 1 (NTR1) [42].
Positive_regulation (activation) of NTR1 associated with analgesia
4) Confidence 0.43 Published 2010 Journal Curr Pain Headache Rep Section Body Doc Link PMC2826634 Disease Relevance 0.78 Pain Relevance 1.58
CGX-1160 is a conopeptide-based drug that produces analgesia through activation of the neurotensin receptor type 1 (NTR1) [42].
Positive_regulation (activation) of neurotensin receptor type 1 associated with analgesia
5) Confidence 0.43 Published 2010 Journal Curr Pain Headache Rep Section Body Doc Link PMC2826634 Disease Relevance 0.78 Pain Relevance 1.58
SN23862 [132] and other mustard analogues [133] are also not substrates for endogenous DT diaphorase, increasing their attractiveness as NTR prodrugs.
Neg (not) Positive_regulation (increasing) of NTR
6) Confidence 0.11 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.25 Pain Relevance 0
All nucleotide substitutions engineered into the sPV1(M) ORF, with the exception of XmaI and StuI restriction sites generated in the 5'NTR and 2B regions, produced silent mutations.
Neg (exception) Positive_regulation (generated) of NTR associated with contagious ecthyma
7) Confidence 0.06 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.75 Pain Relevance 0
Hence, we examined the effect of selected aryl propionic acid NSAIDs and structurally related compounds on the decreased survival of prostate cancer cell lines PC-3, DU-145, and LNCaP by induction of the p75(NTR) protein. p75(NTR) has been shown to function as a tumor suppressor in the prostate by virtue of its intracellular death domain that can initiate apoptosis and inhibit growth.
Spec (examined) Positive_regulation (induction) of NTR in PC-3 associated with cancer, cinod, prostate cancer, apoptosis and death
8) Confidence 0.05 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.94 Pain Relevance 0.51
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Positive_regulation (induction) of NTR
9) Confidence 0.05 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.77 Pain Relevance 0.35
R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction.
Positive_regulation (induction) of NTR associated with stomach cancer and metastasis
10) Confidence 0.05 Published 2010 Journal Mol. Pharm. Section Title Doc Link 19916560 Disease Relevance 1.42 Pain Relevance 0.43
The anticancer effects of R-flurbiprofen were found to require induction of p75(NTR) via the p38 signaling pathway, suggesting a possible mechanism of action.
Positive_regulation (induction) of NTR
11) Confidence 0.05 Published 2010 Journal Mol. Pharm. Section Abstract Doc Link 19916560 Disease Relevance 1.27 Pain Relevance 0.21
The most efficacious compounds for induction of p75(NTR) and decreased survival, in rank-order, were R-flurbiprofen, ibuprofen, oxaprozin, fenoprofen, naproxen, and ketoprofen.
Positive_regulation (induction) of NTR
12) Confidence 0.04 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.90 Pain Relevance 0.45
Consistent with reports on other cancer cell types, NSAID treatment with R-flurbiprofen increased levels of the tumor suppressor neurotrophin receptor (p75(NTR)) in gastric cancer cells.
Positive_regulation (increased) of NTR associated with cancer, cinod and stomach cancer
13) Confidence 0.03 Published 2010 Journal Mol. Pharm. Section Abstract Doc Link 19916560 Disease Relevance 1.47 Pain Relevance 0.34

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