INT68665

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 10.30
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) transcription factor binding (Vhl) cytoplasm (Vhl)
Anatomy Link Frequency
ELS 2
germline 1
Vhl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 98.88 Very High Very High Very High
imagery 7 97.24 Very High Very High Very High
intrathecal 1 95.60 Very High Very High Very High
medulla 2 93.88 High High
Central nervous system 2 90.24 High High
Spinal cord 1 89.72 High High
anesthesia 1 85.52 High High
headache 2 81.76 Quite High
Sciatica 3 65.68 Quite High
Catecholamine 2 65.36 Quite High
Disease Link Frequency Relevance Heat
Syndrome 153 100.00 Very High Very High Very High
Watson Syndrome 2 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 1 100.00 Very High Very High Very High
Cancer 161 99.98 Very High Very High Very High
Von Hippel-lindau Syndrome 8 99.96 Very High Very High Very High
Renal Cancer 276 99.92 Very High Very High Very High
Hemangioblastoma 6 99.88 Very High Very High Very High
Disease 28 99.84 Very High Very High Very High
Pheochromocytoma 60 99.80 Very High Very High Very High
Paraganglioma 31 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings corroborate those in current medical literature, showing an increased morbidity of this tumor when associated with vHL.
vHL Binding (associated) of associated with cancer
1) Confidence 0.48 Published 2000 Journal Arq Neuropsiquiatr Section Abstract Doc Link 10849633 Disease Relevance 0.70 Pain Relevance 0.08
We describe here the case of a 48 years old woman with a pure radicular hemangioblastoma, not associated with VHL, presenting with radicular pain, diagnosed with magnetic ressonance imaging (MRI) and submitted to total resection with a very good outcome.
VHL Binding (associated) of associated with hemangioblastoma, pain and imagery
2) Confidence 0.42 Published 2003 Journal Arq Neuropsiquiatr Section Abstract Doc Link 12894284 Disease Relevance 0.63 Pain Relevance 0.28
Haemangioblastomas occur sporadically or in association with Von Hippel-Lindau (VHL) disease.
Von Hippel-Lindau Binding (association) of associated with disease
3) Confidence 0.31 Published 2006 Journal J Clin Neurosci Section Abstract Doc Link 17049241 Disease Relevance 0.23 Pain Relevance 0.15
We have demonstrated through molecular biological techniques, that, in our patient's tumor, a genetic mutation occurred, and that this mutation is similar to mutations previously reported in other neoplasms associated with vHL.
vHL Binding (associated) of
4) Confidence 0.29 Published 1997 Journal Neurosurgery Section Body Doc Link 9092862 Disease Relevance 0 Pain Relevance 0
CONCLUSION: ELS tumors are uncommon, and, to our knowledge, only seven cases associated with vHL disease have been reported in the literature.
vHL Binding (associated) of in ELS
5) Confidence 0.22 Published 1997 Journal Neurosurgery Section Body Doc Link 9092862 Disease Relevance 0.13 Pain Relevance 0
We therefore suggest that ELS tumors be considered among the neoplasms associated with vHL.


vHL Binding (associated) of in ELS
6) Confidence 0.22 Published 1997 Journal Neurosurgery Section Body Doc Link 9092862 Disease Relevance 0 Pain Relevance 0
The pheochromocytomas can be a part of some of the hereditary syndromes, including MEN2, VHL, NF1, and paraganglioma syndrome.
VHL Binding (part) of associated with syndrome, paraganglioma and pheochromocytoma
7) Confidence 0.13 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2254511 Disease Relevance 1.88 Pain Relevance 0.05
Each

inherited cancer syndrome, such as VHL, HPRC and hereditary leiomyomatosis and

VHL Binding (syndrome) of associated with leiomyomatosis, syndrome, cancer and renal cancer
8) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 3.29 Pain Relevance 0.03
Von Hippel-Lindau (VHL)
VHL Binding (Von Hippel-Lindau) of
9) Confidence 0.05 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.21 Pain Relevance 0.08
So far, germline mutations in five genes have been identified to be responsible for familial PHEOs: the von Hippel-Lindau gene, which causes von Hippel-Lindau syndrome, the RET gene leading to multiple endocrine neoplasia type 2, the neurofibromatosis type 1 gene, which is associated with von Recklinghausen's disease and the genes encoding the B and D subunits of mitochondrial succinate dehydrogenase (SDHB, SDHD), which are associated with familial paragangliomas and PHEOs.
Hippel-Lindau gene Binding (associated) of in germline associated with multiple endocrine neoplasia type 2a, syndrome, paraganglioma, disease and watson syndrome
10) Confidence 0.01 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17119341 Disease Relevance 1.21 Pain Relevance 0.15

General Comments

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