INT6867

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 13.46
Pain Relevance 9.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GFAP) extracellular matrix organization (GFAP) cytoplasm (GFAP)
Anatomy Link Frequency
astrocytes 16
proximal 4
retina 2
IB4 2
neural 2
GFAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 118 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
Hyperalgesia 11 100.00 Very High Very High Very High
allodynia 9 100.00 Very High Very High Very High
Thermal hyperalgesia 4 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Morphine 71 99.82 Very High Very High Very High
Sciatic nerve 11 99.48 Very High Very High Very High
intrathecal 9 99.36 Very High Very High Very High
Central nervous system 32 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 16 100.00 Very High Very High Very High
Neuropathic Pain 15 100.00 Very High Very High Very High
Cancer 9 100.00 Very High Very High Very High
Convulsion 9 99.76 Very High Very High Very High
Pain 29 99.64 Very High Very High Very High
Stroke 95 99.54 Very High Very High Very High
Reprotox - General 1 9 99.10 Very High Very High Very High
Neuroblastoma 22 98.60 Very High Very High Very High
Injury 102 98.40 Very High Very High Very High
Ocular Hypertension 34 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Astrocytes undergo a process of prolifiration, morphological change, and enhancement of glial fibrillary acidic protein expression, termed activation of astrocytes.
Positive_regulation (enhancement) of Gene_expression (expression) of glial fibrillary acidic protein in astrocytes
1) Confidence 0.67 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16637594 Disease Relevance 0 Pain Relevance 0.43
In addition, there was an increase in the expression of glial fibrillary acidic protein (GFAP) in DRG satellite cells and an increase in the number of CD68 positive activated macrophages within the DRG and peripheral nerve.
Positive_regulation (increase) of Gene_expression (expression) of GFAP in DRG
2) Confidence 0.67 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17005179 Disease Relevance 0.98 Pain Relevance 0.60
Spinal GFAP expression was significantly increased by FeCl(2) and intrathecal injection of carbenoxolone (an astrocyte gap junction decoupler) at day 3 significantly reduced TIIP, suggesting that spinal astrocyte activation plays an important role.
Positive_regulation (increased) of Gene_expression (expression) of GFAP in Spinal associated with pain and intrathecal
3) Confidence 0.45 Published 2008 Journal Pain Section Abstract Doc Link 18691814 Disease Relevance 2.15 Pain Relevance 1.66
Dissociation of these neurospheres and removal of mitogens results in expression of the characteristic Schwann cell markers S100 and p75 nerve growth factor receptor and GFAP.
Positive_regulation (results) of Gene_expression (expression) of GFAP in Schwann cell associated with nerve growth factor
4) Confidence 0.45 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19699793 Disease Relevance 0.23 Pain Relevance 0.19
Our results as depicted in Figure 5A provide direct evidence that neurotoxic mediators released from infected human neuroblastoma cell line SK-N-SH can activate astrocytes as measured by significant increase in the expression of GFAP.
Positive_regulation (increase) of Gene_expression (expression) of GFAP in astrocytes associated with neuroblastoma
5) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 0.56 Pain Relevance 0.44
Increased GFAP expression as a marker of astrocyte activation has been documented in various studies [67,68].
Positive_regulation (Increased) of Gene_expression (expression) of GFAP in astrocyte
6) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 0.50 Pain Relevance 0.44
Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury.
Positive_regulation (increases) of in sciatic nerve Gene_expression (Staining) of acidic protein in spinal cord associated with pain, injury, sciatic nerve and spinal cord
7) Confidence 0.41 Published 1991 Journal Brain Res. Section Title Doc Link 1723019 Disease Relevance 0.60 Pain Relevance 0.64
In sections that were dually labeled for human nestin and GFAP, the two phenotypes were expressed by distinct populations of NSC-derived cells, i.e. the vast majority of GFAP (+) cells were nestin (?)
Positive_regulation (sections) of Gene_expression (labeled) of GFAP
8) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1796906 Disease Relevance 0 Pain Relevance 0.06
Our working model of damage in ocular hypertensive glaucoma states that abnormally elevated intraocular pressure converts normal optic nerve head astrocytes to "reactive" astrocytes, which are characterized by the increased expression of glial fibrillary acidic protein (GFAP) [10,18,19], a member of the intermediate filament family uniquely expressed by astrocytes and considered to be a hallmark of central nervous system injury [20].
Positive_regulation (increased) of Gene_expression (expression) of acidic protein in astrocytes associated with nervous system injury, hypertension, glaucoma, central nervous system and ocular hypertension
9) Confidence 0.29 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.76 Pain Relevance 0.05
As shown in Figure 1E, after 3 days of in vitro culture, the de-ATSC overexpressed several stemness genes such as Oct4, sox2, Nanog, and Rex1 with downregulation of the mature neural marker proteins, GFAP, TuJ, and MAP2ab.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GFAP in neural
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.46 Pain Relevance 0
The results showed that: (1) inoculation of prostate cancer cells, but not the vehicle Hank's solution, induced progressive bone destruction at the proximal epiphysis of the tibia from day 7-20 post inoculation; (2) the inoculation also induced progressive thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia, and spontaneous flinches; (3) astrocytes and microglia were significantly activated in the spinal cord ipsilateral to the cancer leg, characterized by enhanced immunostaining of both glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglial marker); (4) IL-1beta was up-regulated in the ipsilateral spinal cord, evidenced by an increase of IL-1beta immunostained astrocytes.
Positive_regulation (induced) of Gene_expression (immunostaining) of acidic protein in proximal associated with hyperalgesia, allodynia, cancer, thermal hyperalgesia, reprotox - general 1 and spinal cord
11) Confidence 0.07 Published 2005 Journal Pain Section Abstract Doc Link 16154703 Disease Relevance 1.71 Pain Relevance 1.45
The results showed that: (1) inoculation of prostate cancer cells, but not the vehicle Hank's solution, induced progressive bone destruction at the proximal epiphysis of the tibia from day 7-20 post inoculation; (2) the inoculation also induced progressive thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia, and spontaneous flinches; (3) astrocytes and microglia were significantly activated in the spinal cord ipsilateral to the cancer leg, characterized by enhanced immunostaining of both glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglial marker); (4) IL-1beta was up-regulated in the ipsilateral spinal cord, evidenced by an increase of IL-1beta immunostained astrocytes.
Positive_regulation (enhanced) of Gene_expression (immunostaining) of acidic protein in proximal associated with hyperalgesia, allodynia, cancer, thermal hyperalgesia, reprotox - general 1 and spinal cord
12) Confidence 0.07 Published 2005 Journal Pain Section Abstract Doc Link 16154703 Disease Relevance 1.56 Pain Relevance 1.32
Quantitative changes in the expression of glial fibrillary acidic protein (GFAP), a cytoskeletal intermediate filament protein exclusively expressed in astrocytes (Bignami et al, 1972), have been observed after administration of alcohol (Framke, 1995), morphine (Beitner-Johnson et al., 1993), amphetamine and its derivates (Aguirre et al., 1999), cannabinoids (Suarez et al., 2000), nicotine (Janson and Moller, 1993), caffeine (Marret et al., 1993) and prenatal exposure to cocaine (Clarke et al., 1996; Nassogne et al., 1998).
Positive_regulation (changes) of Gene_expression (expression) of acidic protein in astrocytes associated with nicotine, cannabinoid, cocaine, morphine and alcohol
13) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882367 Disease Relevance 0 Pain Relevance 0.33
The enhanced production of glial fibrillary acidic protein (GFAP) by astroglia appears to be a general response of the CNS to many types of toxic insult.
Positive_regulation (response) of Gene_expression (production) of acidic protein
14) Confidence 0.02 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.07 Pain Relevance 0.07
The enhanced production of glial fibrillary acidic protein (GFAP) by astroglia appears to be a general response of the CNS to many types of toxic insult.
Positive_regulation (enhanced) of Gene_expression (production) of acidic protein
15) Confidence 0.02 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.07 Pain Relevance 0.07
The present report describes another consequence of seizures-a dramatic induction of glial fibrillary acidic protein (GFAP) expression in astrocytes.
Positive_regulation (induction) of Gene_expression (expression) of acidic protein in astrocytes associated with convulsion
16) Confidence 0.01 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 0.82 Pain Relevance 0.03
Immunohistochemical analyses demonstrated enhanced expression of glial fibrillary acidic protein (GFAP) in the glaucomatous retina (Figure 1B).
Positive_regulation (enhanced) of Gene_expression (expression) of acidic protein in retina
17) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965571 Disease Relevance 0.76 Pain Relevance 0
Regarding glial reactivity, we found an early microglial response, with the highest increase of isolectin B4 (IB4) and Iba1 expression at 3 days, and a slower and progressive response of astrocytes, shown by increasing expression of glial fibrillary acidic protein (GFAP) during the 28 days studied.
Positive_regulation (increasing) of Gene_expression (expression) of acidic protein in IB4
18) Confidence 0.01 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.03
Other cells such as astrocytes are also activated exhibiting a hallmark increase in glial fibrillary acidic protein (GFAP) expression [7].
Positive_regulation (increase) of Gene_expression (expression) of acidic protein in astrocytes
19) Confidence 0.01 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1933533 Disease Relevance 1.40 Pain Relevance 0.36
Ultra-low dose naltrexone attenuated morphine-induced increases in the expression of glial fibrillary acidic protein (GFAP) and CD3/CD11B (OX42)
Positive_regulation (increases) of Gene_expression (expression) of acidic protein associated with morphine
20) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.16 Pain Relevance 1.41

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