INT68675

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 7.61
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (APCS) protein folding (APCS) extracellular space (APCS)
extracellular region (APCS) protein complex (APCS)
Anatomy Link Frequency
plasma 1
cheek 1
LSG 1
T cell 1
APCS (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 19 100.00 Very High Very High Very High
Inflammation 40 99.98 Very High Very High Very High
Dopamine 232 99.82 Very High Very High Very High
fibrosis 90 96.56 Very High Very High Very High
lidocaine 3 93.08 High High
Analgesic 3 92.36 High High
palliative 6 90.56 High High
agonist 12 82.36 Quite High
cytokine 25 70.60 Quite High
Opioid 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 12 100.00 Very High Very High Very High
Stable Angina Pectoris 10 100.00 Very High Very High Very High
INFLAMMATION 41 99.98 Very High Very High Very High
Mucositis 129 99.66 Very High Very High Very High
Hypoxia 224 98.88 Very High Very High Very High
Disease 12 97.84 Very High Very High Very High
Influenza Virus Infection 70 96.76 Very High Very High Very High
Fibrosis 123 96.56 Very High Very High Very High
Amyloidosis 7 96.32 Very High Very High Very High
Cv General 3 Under Development 9 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine induced a significant increase in HR, systolic, mean and diastolic SAP in anesthetized models without any statistically significant effect on HR and SAP in the conscious model.
Neg (without) Regulation (effect) of SAP
1) Confidence 0.62 Published 2008 Journal J Pharmacol Toxicol Methods Section Body Doc Link 18583160 Disease Relevance 0 Pain Relevance 0
Anaesthesia and surgery did not affect SAP plasma levels while patients showed a major increase in CRP concentrations preceding the cytokine responses.
Neg (not) Regulation (affect) of SAP in plasma
2) Confidence 0.48 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9527747 Disease Relevance 0.06 Pain Relevance 0
One patient showed no changes in SAP amplitude.
Neg (no) Regulation (changes) of SAP
3) Confidence 0.44 Published 2008 Journal J. Neurol. Neurosurg. Psychiatr. Section Body Doc Link 18450790 Disease Relevance 0 Pain Relevance 0
Therefore the anti-inflammatory effect of SAP treatment on mucositis may occur via a similar mechanism.
Regulation (effect) of SAP associated with mucositis and inflammation
4) Confidence 0.28 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0.84 Pain Relevance 0.33
In this study, we used an established hamster cheek-pouch model of radiation-induced mucositis to determine if SAP treatment affects either the clinical or pathological hallmarks of the disease.
Spec (determine) Regulation (affects) of SAP in cheek associated with mucositis and disease
5) Confidence 0.28 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0.88 Pain Relevance 0.47
We studied the value of serum amyloid P component (SAP) scintigraphy and labial salivary gland (LSG) biopsy on patients with apparently localized amyloidosis in 12 patients who had neither clinical nor biological evidence of systemic amyloidosis.
Regulation (value) of SAP in LSG associated with amyloidosis and alzheimer's dementia
6) Confidence 0.26 Published 1997 Journal QJM Section Abstract Doc Link 9093588 Disease Relevance 0.65 Pain Relevance 0
The difference in anti-oxLDL levels between patients with SAP and the controls was also statistically significant.
Regulation (controls) of SAP associated with angina
7) Confidence 0.20 Published 2005 Journal Free Radic. Res. Section Abstract Doc Link 16028367 Disease Relevance 1.74 Pain Relevance 1.38
Another significant effect of SAP was observed at day 26, with SAP-treated animals having a lower mean mucositis score (0.25 ± 0.11) than vehicle control hamsters (P < 0.01).
Regulation (effect) of SAP associated with mucositis
8) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 1.26 Pain Relevance 0.06
In particular, we wondered whether the site of antigen delivery would affect the nature and the quality of the immune response and whether this method of targeting the skin's APCs would be capable of inducing CD8 T cell responses to a conventional inactivated influenza vaccine designed to induce vaccine-specific antibodies.
Spec (whether) Regulation (targeting) of APCs in T cell associated with influenza virus infection
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.39 Pain Relevance 0
Dopamine did not affect the SAP and CI at any dose, although it might increase SAP and CI at a dose of 32 ?
Neg (not) Regulation (affect) of SAP associated with dopamine
10) Confidence 0.10 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.47 Pain Relevance 0.19
No significant changes in SAP, SVRI, PVFI, HAFI, THFI, or MVRI were demonstrated.
Neg (No) Regulation (changes) of SAP
11) Confidence 0.07 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.51 Pain Relevance 0.06
Epinephrine increased CI at all doses, with no significant effects on SAP and SVRI.
Neg (no) Regulation (effects) of SAP
12) Confidence 0.06 Published 2001 Journal Crit Care Section Abstract Doc Link PMC31580 Disease Relevance 0.34 Pain Relevance 0.29
There was no significant effect on SAP, CI (Fig. 1) or calculated SVRI (Fig. 2) with any dose of dopamine, PAP was elevated at all doses, and a significant increase in calculated PVRI was demonstrated only at 10 ?
Neg (no) Regulation (effect) of SAP associated with dopamine
13) Confidence 0.06 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.48 Pain Relevance 0.24

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