INT6868

Context Info Confidence 0.78 First Reported 1984 Last Reported 2011 Negated 16 Speculated 0 Reported most in Abstract Documents 136 Total Number 136 Disease Relevance 84.65 Pain Relevance 22.70

cytosol (GFAP) extracellular matrix organization (GFAP) cytoplasm (GFAP)

Anatomy Link Frequency astrocytes 30 neuron 6 smooth muscle 4 spinal cord 4 stem cells 4 GFAP (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 73 100.00 Nerve growth factor 34 100.00 Neuropeptide 7 100.00 calcitonin gene related peptide 2 100.00 Neuritis 24 99.84 Morphine 75 99.48 Spinal cord 1039 99.28 cocaine 17 98.66 Enkephalin 11 98.48 Inflammation 307 98.40

Disease Link Frequency Relevance Heat Cicatrix 243 100.00 Chromosome Deletion 1 100.00 Injury 1925 99.88 Cancer 884 99.86 Gliosis 33 99.84 Neurocytoma 18 99.84 Experimental Autoimmune Neuritis 14 99.84 Gastrointestinal Stromal Tumor 7 99.80 Primary Sclerosing Cholangitis 26 99.70 Pain 59 99.64

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemical examination demonstrated xanthomatous cells expressing glial fibrillary acidic protein.

Gene_expression (expressing) of glial fibrillary acidic protein

1) Confidence 0.78 Published 2009 Journal No Shinkei Geka Section Abstract Doc Link 19522287 Disease Relevance 0.34 Pain Relevance 0.13

Astrocytes undergo a process of prolifiration, morphological change, and enhancement of glial fibrillary acidic protein expression, termed activation of astrocytes.

Gene_expression (expression) of glial fibrillary acidic protein in astrocytes

2) Confidence 0.75 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16637594 Disease Relevance 0 Pain Relevance 0.42

To define the population of cells injured by paclitaxel, we examined the expression of activating transcription factor-3 (ATF3), a marker of cell injury; to define the hypertrophy of satellite cells, we quantified the expression of the intermediate filament protein glial fibrillary acidic protein (GFAP); and to define the activation of macrophages, we examined the expression of the lysosomal protein CD68.

Gene_expression (expression) of GFAP in macrophages associated with hypertrophy and injury

3) Confidence 0.75 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16854522 Disease Relevance 0.75 Pain Relevance 0.12

Immunohistochemical studies were positive for MIC-2, NSE, C-KIT, vimentin, Class III-beta tublin and glycogen, but negative for NFP, synaptophysin, chromogranin A and GFAP.

Neg (negative) Gene_expression (negative) of GFAP

4) Confidence 0.75 Published 2004 Journal No To Shinkei Section Abstract Doc Link 15112448 Disease Relevance 1.10 Pain Relevance 0.12

Immortal RLT-PSC cells retained the phenotype of activated PSC proven by the expression of alpha-smooth muscle actin (alphaSMA), vimentin, desmin and glial fibrillary acidic protein (GFAP).

Gene_expression (expression) of GFAP in smooth muscle associated with primary sclerosing cholangitis

5) Confidence 0.75 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.09 Pain Relevance 0.13

Tumor cells expressed GFAP and S-100 and to lesser extent carbonic anhydrase II.

Gene_expression (expressed) of GFAP associated with cancer

6) Confidence 0.75 Published 2005 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16160486 Disease Relevance 0.81 Pain Relevance 0.13

In addition, there was an increase in the expression of glial fibrillary acidic protein (GFAP) in DRG satellite cells and an increase in the number of CD68 positive activated macrophages within the DRG and peripheral nerve.

Gene_expression (expression) of GFAP in DRG

7) Confidence 0.75 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17005179 Disease Relevance 0.97 Pain Relevance 0.60

RESULTS AND CONCLUSION: Immunohistochemical glial fibrillary acid protein (GFAP) expression was seen only in the glioblastoma portion.

Gene_expression (expression) of GFAP

8) Confidence 0.75 Published 2009 Journal Acta Neurochir (Wien) Section Body Doc Link 19399365 Disease Relevance 0.08 Pain Relevance 0

Type II cells were identified in only one of five high-grade (malignant) paragangliomas and that tumor contained vanishingly rare cells that were weakly S-100 protein positive but GFAP negative.

Neg (negative) Gene_expression (negative) of GFAP associated with malignant neoplastic disease, cancer and paraganglioma

9) Confidence 0.75 Published 1989 Journal Hum. Pathol. Section Abstract Doc Link 2912871 Disease Relevance 0.91 Pain Relevance 0.22

Early lesions displayed abundant Gfap-positive cells, although the larger tumors partly lost the expression of Gfap.

Gene_expression (expression) of Gfap associated with cancer

10) Confidence 0.75 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.01 Pain Relevance 0

Dissociation of these neurospheres and removal of mitogens results in expression of the characteristic Schwann cell markers S100 and p75 nerve growth factor receptor and GFAP.

Gene_expression (expression) of GFAP in Schwann cell associated with nerve growth factor

11) Confidence 0.75 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19699793 Disease Relevance 0.23 Pain Relevance 0.19

Immunohistochemically, the tumor cells were diffusely and strongly positive for epithelial membrane antigen and vimentin, and showed focal expression of glial fibrillary acidic protein, pancytokeratin, and neurofilament protein.

Gene_expression (expression) of glial fibrillary acidic protein associated with cancer

12) Confidence 0.75 Published 2010 Journal J. Neurosurg. Section Abstract Doc Link 19911885 Disease Relevance 1.49 Pain Relevance 0.07

CD34 and CD117 were used to exclude a gastrointestinal stromal tumour, whereas GFAP expression confirmed neural differentiation.

Gene_expression (expression) of GFAP in neural associated with gastrointestinal stromal tumor

13) Confidence 0.73 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430707 Disease Relevance 1.10 Pain Relevance 0.11

We found the expression of human GAPDH, GFAP, NG2, TUJ1, and MAP2 but not in the control rats or nonlesioned part of the spinal cord (Supporting Information Fig. 5) confirming the presence of differentiated hESC.

Gene_expression (expression) of GFAP in spinal cord associated with spinal cord

14) Confidence 0.71 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.15 Pain Relevance 0.11

These cells finally matured to astrocytes, oligodendrocytes, and neurons (expressing GFAP, NG2, and TUJ1, respectively; Supporting Information Fig. 5) but only OPC and OPC + MP expressed human MAP2 (marker for postmitotic neurons), which is an additional proof of a triple fate of OPC and MP.

Gene_expression (expressing) of GFAP in oligodendrocytes

15) Confidence 0.71 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.30 Pain Relevance 0.11

Immortal RLT-PSC cells retained the phenotype of activated PSC proven by the expression of alpha-smooth muscle actin (alphaSMA), vimentin, desmin and glial fibrillary acidic protein (GFAP).

Gene_expression (expression) of glial fibrillary acidic protein in smooth muscle associated with primary sclerosing cholangitis

16) Confidence 0.68 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.08 Pain Relevance 0.13

S-100 protein, SMA and GFAP were negative.

Neg (negative) Gene_expression (negative) of GFAP

17) Confidence 0.67 Published 2003 Journal Pathol. Int. Section Abstract Doc Link 14516322 Disease Relevance 1.49 Pain Relevance 0.06

Immunohistochemically, the tumor cells were positive for glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, and negative for cytokeratin, synaptophysin.

Neg (negative) Gene_expression (positive) of glial fibrillary acidic protein associated with cancer

18) Confidence 0.66 Published 2003 Journal Neurol. Res. Section Abstract Doc Link 12870256 Disease Relevance 0.57 Pain Relevance 0.18

The surrounding hepatic tissue was negative for GFAP.

Neg (negative) Gene_expression (negative) of GFAP

19) Confidence 0.65 Published 2003 Journal Brain Pathol. Section Abstract Doc Link 12946033 Disease Relevance 0.89 Pain Relevance 0.12

Immunohistochemically, the neoplastic cells were positive for S-100 protein (diffuse and strong), CD34 (primarily in Antoni B areas), glial fibrillary acidic protein (GFAP; weak and diffuse) and calretinin (mainly in Antoni A areas), while none was positive for CD31, estrogen and progesterone receptors, bcl-2, or epithelial membrane antigen (EMA).

Gene_expression (positive) of GFAP

20) Confidence 0.65 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15998381 Disease Relevance 0.92 Pain Relevance 0.12

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